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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MDM2
Full Name:
E3 ubiquitin-protein ligase Mdm2
Alias:
Double minute 2 protein; Hdm2; HDM2; HDMX; Mdm2 p53 binding protein; MGC5370; Oncoprotein Mdm2; P53-binding protein Mdm2; Ubiquitin-protein ligase E3 Mdm2
Type:
Ligase; Ubiquitin ligase; Inhibitor protein; Ubiquitin conjugating system; EC 6.3.2.-
Mass (Da):
55233
Number AA:
491
UniProt ID:
Q00987
International Prot ID:
IPI00218551
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0030666
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0017163
GO:0019899
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0000122
GO:0008284
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
T
D
G
A
V
T
T
S
Q
I
P
A
S
E
Q
Site 2
S22
T
T
S
Q
I
P
A
S
E
Q
E
T
L
V
R
Site 3
T26
I
P
A
S
E
Q
E
T
L
V
R
P
K
P
L
Site 4
Y48
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Site 5
T49
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
Site 6
Y60
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
Site 7
Y67
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
Site 8
Y76
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
Site 9
S90
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
Site 10
S92
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Site 11
Y100
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
Site 12
Y104
R
K
I
Y
T
M
I
Y
R
N
L
V
V
V
N
Site 13
S116
V
V
N
Q
Q
E
S
S
D
S
G
T
S
V
S
Site 14
S118
N
Q
Q
E
S
S
D
S
G
T
S
V
S
E
N
Site 15
T120
Q
E
S
S
D
S
G
T
S
V
S
E
N
R
C
Site 16
S121
E
S
S
D
S
G
T
S
V
S
E
N
R
C
H
Site 17
S123
S
D
S
G
T
S
V
S
E
N
R
C
H
L
E
Site 18
S148
E
L
Q
E
E
K
P
S
S
S
H
L
V
S
R
Site 19
S149
L
Q
E
E
K
P
S
S
S
H
L
V
S
R
P
Site 20
S150
Q
E
E
K
P
S
S
S
H
L
V
S
R
P
S
Site 21
S154
P
S
S
S
H
L
V
S
R
P
S
T
S
S
R
Site 22
S157
S
H
L
V
S
R
P
S
T
S
S
R
R
R
A
Site 23
T158
H
L
V
S
R
P
S
T
S
S
R
R
R
A
I
Site 24
S159
L
V
S
R
P
S
T
S
S
R
R
R
A
I
S
Site 25
S160
V
S
R
P
S
T
S
S
R
R
R
A
I
S
E
Site 26
S166
S
S
R
R
R
A
I
S
E
T
E
E
N
S
D
Site 27
T168
R
R
R
A
I
S
E
T
E
E
N
S
D
E
L
Site 28
S172
I
S
E
T
E
E
N
S
D
E
L
S
G
E
R
Site 29
S176
E
E
N
S
D
E
L
S
G
E
R
Q
R
K
R
Site 30
S186
R
Q
R
K
R
H
K
S
D
S
I
S
L
S
F
Site 31
S188
R
K
R
H
K
S
D
S
I
S
L
S
F
D
E
Site 32
S190
R
H
K
S
D
S
I
S
L
S
F
D
E
S
L
Site 33
S192
K
S
D
S
I
S
L
S
F
D
E
S
L
A
L
Site 34
S210
R
E
I
C
C
E
R
S
S
S
S
E
S
T
G
Site 35
S211
E
I
C
C
E
R
S
S
S
S
E
S
T
G
T
Site 36
S212
I
C
C
E
R
S
S
S
S
E
S
T
G
T
P
Site 37
S213
C
C
E
R
S
S
S
S
E
S
T
G
T
P
S
Site 38
S215
E
R
S
S
S
S
E
S
T
G
T
P
S
N
P
Site 39
T216
R
S
S
S
S
E
S
T
G
T
P
S
N
P
D
Site 40
T218
S
S
S
E
S
T
G
T
P
S
N
P
D
L
D
Site 41
S220
S
E
S
T
G
T
P
S
N
P
D
L
D
A
G
Site 42
S229
P
D
L
D
A
G
V
S
E
H
S
G
D
W
L
Site 43
S240
G
D
W
L
D
Q
D
S
V
S
D
Q
F
S
V
Site 44
S242
W
L
D
Q
D
S
V
S
D
Q
F
S
V
E
F
Site 45
S246
D
S
V
S
D
Q
F
S
V
E
F
E
V
E
S
Site 46
S253
S
V
E
F
E
V
E
S
L
D
S
E
D
Y
S
Site 47
S256
F
E
V
E
S
L
D
S
E
D
Y
S
L
S
E
Site 48
Y259
E
S
L
D
S
E
D
Y
S
L
S
E
E
G
Q
Site 49
S260
S
L
D
S
E
D
Y
S
L
S
E
E
G
Q
E
Site 50
S262
D
S
E
D
Y
S
L
S
E
E
G
Q
E
L
S
Site 51
S269
S
E
E
G
Q
E
L
S
D
E
D
D
E
V
Y
Site 52
Y276
S
D
E
D
D
E
V
Y
Q
V
T
V
Y
Q
A
Site 53
T279
D
D
E
V
Y
Q
V
T
V
Y
Q
A
G
E
S
Site 54
Y281
E
V
Y
Q
V
T
V
Y
Q
A
G
E
S
D
T
Site 55
S286
T
V
Y
Q
A
G
E
S
D
T
D
S
F
E
E
Site 56
T288
Y
Q
A
G
E
S
D
T
D
S
F
E
E
D
P
Site 57
S290
A
G
E
S
D
T
D
S
F
E
E
D
P
E
I
Site 58
Y302
P
E
I
S
L
A
D
Y
W
K
C
T
S
C
N
Site 59
S342
G
K
D
K
G
E
I
S
E
K
A
K
L
E
N
Site 60
S350
E
K
A
K
L
E
N
S
T
Q
A
E
E
G
F
Site 61
T351
K
A
K
L
E
N
S
T
Q
A
E
E
G
F
D
Site 62
T365
D
V
P
D
C
K
K
T
I
V
N
D
S
R
E
Site 63
S373
I
V
N
D
S
R
E
S
C
V
E
E
N
D
D
Site 64
T383
E
E
N
D
D
K
I
T
Q
A
S
Q
S
Q
E
Site 65
S386
D
D
K
I
T
Q
A
S
Q
S
Q
E
S
E
D
Site 66
S388
K
I
T
Q
A
S
Q
S
Q
E
S
E
D
Y
S
Site 67
S391
Q
A
S
Q
S
Q
E
S
E
D
Y
S
Q
P
S
Site 68
Y394
Q
S
Q
E
S
E
D
Y
S
Q
P
S
T
S
S
Site 69
S395
S
Q
E
S
E
D
Y
S
Q
P
S
T
S
S
S
Site 70
S398
S
E
D
Y
S
Q
P
S
T
S
S
S
I
I
Y
Site 71
T399
E
D
Y
S
Q
P
S
T
S
S
S
I
I
Y
S
Site 72
S400
D
Y
S
Q
P
S
T
S
S
S
I
I
Y
S
S
Site 73
S401
Y
S
Q
P
S
T
S
S
S
I
I
Y
S
S
Q
Site 74
S402
S
Q
P
S
T
S
S
S
I
I
Y
S
S
Q
E
Site 75
Y405
S
T
S
S
S
I
I
Y
S
S
Q
E
D
V
K
Site 76
S406
T
S
S
S
I
I
Y
S
S
Q
E
D
V
K
E
Site 77
S407
S
S
S
I
I
Y
S
S
Q
E
D
V
K
E
F
Site 78
T419
K
E
F
E
R
E
E
T
Q
D
K
E
E
S
V
Site 79
S425
E
T
Q
D
K
E
E
S
V
E
S
S
L
P
L
Site 80
S429
K
E
E
S
V
E
S
S
L
P
L
N
A
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation