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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE1B
Full Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Alias:
63 kDa Cam-PDE; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cam-PDE 1B; EC 3.1.4.17; PDE1B1; PDES1B; Phosphodiesterase 1B, calmodulin-dependent
Type:
Phosphodiesterase; Apoptosis; EC 3.1.4.17; Nucleotide Metabolism - purine
Mass (Da):
61380
Number AA:
536
UniProt ID:
Q01064
International Prot ID:
IPI00005592
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0004117
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007165
GO:0008542
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
L
S
P
R
S
P
P
E
M
L
E
E
Site 2
S15
P
P
E
M
L
E
E
S
D
C
P
S
P
L
E
Site 3
S19
L
E
E
S
D
C
P
S
P
L
E
L
K
S
A
Site 4
S25
P
S
P
L
E
L
K
S
A
P
S
K
K
M
W
Site 5
Y41
K
L
R
S
L
L
R
Y
M
V
K
Q
L
E
N
Site 6
Y62
E
L
K
K
N
L
E
Y
T
A
S
L
L
E
A
Site 7
Y71
A
S
L
L
E
A
V
Y
I
D
E
T
R
Q
I
Site 8
T81
E
T
R
Q
I
L
D
T
E
D
E
L
Q
E
L
Site 9
S90
D
E
L
Q
E
L
R
S
D
A
V
P
S
E
V
Site 10
S103
E
V
R
D
W
L
A
S
T
F
T
Q
Q
A
R
Site 11
T104
V
R
D
W
L
A
S
T
F
T
Q
Q
A
R
A
Site 12
S124
E
E
K
P
K
F
R
S
I
V
H
A
V
Q
A
Site 13
T142
V
E
R
M
F
R
R
T
Y
T
S
V
G
P
T
Site 14
Y143
E
R
M
F
R
R
T
Y
T
S
V
G
P
T
Y
Site 15
T144
R
M
F
R
R
T
Y
T
S
V
G
P
T
Y
S
Site 16
S145
M
F
R
R
T
Y
T
S
V
G
P
T
Y
S
T
Site 17
T149
T
Y
T
S
V
G
P
T
Y
S
T
A
V
L
N
Site 18
T152
S
V
G
P
T
Y
S
T
A
V
L
N
C
L
K
Site 19
S195
L
T
R
H
N
L
I
S
R
F
K
I
P
T
V
Site 20
T201
I
S
R
F
K
I
P
T
V
F
L
M
S
F
L
Site 21
T213
S
F
L
D
A
L
E
T
G
Y
G
K
Y
K
N
Site 22
Y218
L
E
T
G
Y
G
K
Y
K
N
P
Y
H
N
Q
Site 23
Y222
Y
G
K
Y
K
N
P
Y
H
N
Q
I
H
A
A
Site 24
Y265
F
A
A
A
I
H
D
Y
E
H
T
G
T
T
N
Site 25
S273
E
H
T
G
T
T
N
S
F
H
I
Q
T
K
S
Site 26
Y286
K
S
E
C
A
I
V
Y
N
D
R
S
V
L
E
Site 27
S299
L
E
N
H
H
I
S
S
V
F
R
L
M
Q
D
Site 28
S407
A
E
L
G
L
P
F
S
P
L
C
D
R
T
S
Site 29
S414
S
P
L
C
D
R
T
S
T
L
V
A
Q
S
Q
Site 30
T415
P
L
C
D
R
T
S
T
L
V
A
Q
S
Q
I
Site 31
S443
L
T
D
V
A
E
K
S
V
Q
P
L
A
D
E
Site 32
S452
Q
P
L
A
D
E
D
S
K
S
K
N
Q
P
S
Site 33
S454
L
A
D
E
D
S
K
S
K
N
Q
P
S
F
Q
Site 34
S459
S
K
S
K
N
Q
P
S
F
Q
W
R
Q
P
S
Site 35
S466
S
F
Q
W
R
Q
P
S
L
D
V
E
V
G
D
Site 36
S480
D
P
N
P
D
V
V
S
F
R
S
T
W
V
K
Site 37
T484
D
V
V
S
F
R
S
T
W
V
K
R
I
Q
E
Site 38
S502
K
W
K
E
R
A
A
S
G
I
T
N
Q
M
S
Site 39
S509
S
G
I
T
N
Q
M
S
I
D
E
L
S
P
C
Site 40
S514
Q
M
S
I
D
E
L
S
P
C
E
E
E
A
P
Site 41
S523
C
E
E
E
A
P
P
S
P
A
E
D
E
H
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation