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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
U2AF1
Full Name:
Splicing factor U2AF 35 kDa subunit
Alias:
RN; RNU2AF1; Splicing factor U2AF 35 kDa; U2 auxiliary factor 35 kDa; U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2af1; U2AF35; U2AFBP
Type:
RNA processing; RNA binding protein
Mass (Da):
27872
Number AA:
240
UniProt ID:
Q01081
International Prot ID:
IPI00005613
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0015030
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
A
E
Y
L
A
S
I
F
G
T
Site 2
S7
_
M
A
E
Y
L
A
S
I
F
G
T
E
K
D
Site 3
T11
Y
L
A
S
I
F
G
T
E
K
D
K
V
N
C
Site 4
S19
E
K
D
K
V
N
C
S
F
Y
F
K
I
G
A
Site 5
Y21
D
K
V
N
C
S
F
Y
F
K
I
G
A
C
R
Site 6
T41
S
R
L
H
N
K
P
T
F
S
Q
T
I
A
L
Site 7
S43
L
H
N
K
P
T
F
S
Q
T
I
A
L
L
N
Site 8
Y52
T
I
A
L
L
N
I
Y
R
N
P
Q
N
S
S
Site 9
S58
I
Y
R
N
P
Q
N
S
S
Q
S
A
D
G
L
Site 10
S59
Y
R
N
P
Q
N
S
S
Q
S
A
D
G
L
R
Site 11
S61
N
P
Q
N
S
S
Q
S
A
D
G
L
R
C
A
Site 12
S70
D
G
L
R
C
A
V
S
D
V
E
M
Q
E
H
Site 13
Y78
D
V
E
M
Q
E
H
Y
D
E
F
F
E
E
V
Site 14
T87
E
F
F
E
E
V
F
T
E
M
E
E
K
Y
G
Site 15
Y93
F
T
E
M
E
E
K
Y
G
E
V
E
E
M
N
Site 16
Y114
D
H
L
V
G
N
V
Y
V
K
F
R
R
E
E
Site 17
S145
Q
P
I
H
A
E
L
S
P
V
T
D
F
R
E
Site 18
Y158
R
E
A
C
C
R
Q
Y
E
M
G
E
C
T
R
Site 19
Y186
R
E
L
R
R
E
L
Y
G
R
R
R
K
K
H
Site 20
S195
R
R
R
K
K
H
R
S
R
S
R
S
R
E
R
Site 21
S197
R
K
K
H
R
S
R
S
R
S
R
E
R
R
S
Site 22
S199
K
H
R
S
R
S
R
S
R
E
R
R
S
R
S
Site 23
S204
S
R
S
R
E
R
R
S
R
S
R
D
R
G
R
Site 24
S206
S
R
E
R
R
S
R
S
R
D
R
G
R
G
G
Site 25
S231
R
E
R
D
R
R
R
S
R
D
R
E
R
S
G
Site 26
S237
R
S
R
D
R
E
R
S
G
R
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation