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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCN7A
Full Name:
Sodium channel protein type 7 subunit alpha
Alias:
SCN6A; sodium channel protein type 7 alpha; sodium channel, voltage-gated, type VII, alpha; voltage-gated sodium channel alpha subunit Nax
Type:
Channel, sodium
Mass (Da):
193473
Number AA:
1682
UniProt ID:
Q01118
International Prot ID:
IPI00300117
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
V
P
F
T
K
E
S
F
E
L
I
K
Q
H
Site 2
Y54
G
K
K
L
P
F
I
Y
G
N
L
S
Q
G
M
Site 3
S58
P
F
I
Y
G
N
L
S
Q
G
M
V
S
E
P
Site 4
Y72
P
L
E
D
V
D
P
Y
Y
Y
K
K
K
N
T
Site 5
Y73
L
E
D
V
D
P
Y
Y
Y
K
K
K
N
T
F
Site 6
Y287
H
N
R
T
G
N
P
Y
Y
I
R
E
T
E
N
Site 7
Y288
N
R
T
G
N
P
Y
Y
I
R
E
T
E
N
F
Site 8
Y296
I
R
E
T
E
N
F
Y
Y
L
E
G
E
R
Y
Site 9
Y297
R
E
T
E
N
F
Y
Y
L
E
G
E
R
Y
A
Site 10
Y303
Y
Y
L
E
G
E
R
Y
A
L
L
C
G
N
R
Site 11
Y354
F
R
L
M
A
Q
D
Y
P
E
V
L
Y
H
L
Site 12
S387
L
F
S
F
Y
M
A
S
L
F
L
G
I
L
A
Site 13
Y397
L
G
I
L
A
M
A
Y
E
E
E
K
Q
R
V
Site 14
S408
K
Q
R
V
G
E
I
S
K
K
I
E
P
K
F
Site 15
T428
E
L
Q
E
G
N
E
T
D
E
A
K
T
I
Q
Site 16
S442
Q
I
E
M
K
K
R
S
P
I
S
T
D
T
S
Site 17
S445
M
K
K
R
S
P
I
S
T
D
T
S
L
D
V
Site 18
T446
K
K
R
S
P
I
S
T
D
T
S
L
D
V
L
Site 19
T448
R
S
P
I
S
T
D
T
S
L
D
V
L
E
D
Site 20
S449
S
P
I
S
T
D
T
S
L
D
V
L
E
D
A
Site 21
T457
L
D
V
L
E
D
A
T
L
R
H
K
E
E
L
Site 22
S467
H
K
E
E
L
E
K
S
K
K
I
C
P
L
Y
Site 23
Y474
S
K
K
I
C
P
L
Y
W
Y
K
F
A
K
T
Site 24
Y527
C
F
L
T
L
E
H
Y
P
M
S
K
Q
T
N
Site 25
S530
T
L
E
H
Y
P
M
S
K
Q
T
N
T
L
L
Site 26
T636
D
L
V
L
L
L
F
T
F
I
F
F
S
A
A
Site 27
Y653
M
K
L
F
G
K
N
Y
E
E
F
V
C
H
I
Site 28
T777
T
Q
N
V
P
K
D
T
M
D
H
V
N
E
V
Site 29
Y785
M
D
H
V
N
E
V
Y
V
K
E
D
I
S
D
Site 30
S791
V
Y
V
K
E
D
I
S
D
H
T
L
S
E
L
Site 31
T794
K
E
D
I
S
D
H
T
L
S
E
L
S
N
T
Site 32
S796
D
I
S
D
H
T
L
S
E
L
S
N
T
Q
D
Site 33
T801
T
L
S
E
L
S
N
T
Q
D
F
L
K
D
K
Site 34
T819
S
G
T
E
K
N
A
T
E
N
E
S
Q
S
L
Site 35
S823
K
N
A
T
E
N
E
S
Q
S
L
I
P
S
P
Site 36
S825
A
T
E
N
E
S
Q
S
L
I
P
S
P
S
V
Site 37
S829
E
S
Q
S
L
I
P
S
P
S
V
S
E
T
V
Site 38
S833
L
I
P
S
P
S
V
S
E
T
V
P
I
A
S
Site 39
T835
P
S
P
S
V
S
E
T
V
P
I
A
S
G
E
Site 40
S855
L
D
N
K
E
I
Q
S
K
S
G
D
G
G
S
Site 41
S857
N
K
E
I
Q
S
K
S
G
D
G
G
S
K
E
Site 42
S862
S
K
S
G
D
G
G
S
K
E
K
I
K
Q
S
Site 43
S869
S
K
E
K
I
K
Q
S
S
S
S
E
C
S
T
Site 44
S870
K
E
K
I
K
Q
S
S
S
S
E
C
S
T
V
Site 45
S871
E
K
I
K
Q
S
S
S
S
E
C
S
T
V
D
Site 46
S872
K
I
K
Q
S
S
S
S
E
C
S
T
V
D
I
Site 47
S875
Q
S
S
S
S
E
C
S
T
V
D
I
A
I
S
Site 48
T876
S
S
S
S
E
C
S
T
V
D
I
A
I
S
E
Site 49
S882
S
T
V
D
I
A
I
S
E
E
E
E
M
F
Y
Site 50
Y889
S
E
E
E
E
M
F
Y
G
G
E
R
S
K
H
Site 51
S905
K
N
G
C
R
R
G
S
S
L
G
Q
I
S
G
Site 52
S906
N
G
C
R
R
G
S
S
L
G
Q
I
S
G
A
Site 53
S911
G
S
S
L
G
Q
I
S
G
A
S
K
K
G
K
Site 54
S914
L
G
Q
I
S
G
A
S
K
K
G
K
I
W
Q
Site 55
Y957
T
L
A
F
E
D
I
Y
I
D
Q
R
K
T
I
Site 56
T963
I
Y
I
D
Q
R
K
T
I
K
I
L
L
E
Y
Site 57
Y990
M
L
L
K
W
M
A
Y
G
F
K
A
Y
F
S
Site 58
Y995
M
A
Y
G
F
K
A
Y
F
S
N
G
W
Y
R
Site 59
S1028
E
E
L
K
P
L
I
S
M
K
F
L
R
P
L
Site 60
S1039
L
R
P
L
R
V
L
S
Q
F
E
R
M
K
V
Site 61
Y1085
D
L
F
A
G
R
F
Y
E
C
I
D
P
T
S
Site 62
S1092
Y
E
C
I
D
P
T
S
G
E
R
F
P
S
S
Site 63
S1098
T
S
G
E
R
F
P
S
S
E
V
M
N
K
S
Site 64
S1099
S
G
E
R
F
P
S
S
E
V
M
N
K
S
R
Site 65
S1105
S
S
E
V
M
N
K
S
R
C
E
S
L
L
F
Site 66
S1109
M
N
K
S
R
C
E
S
L
L
F
N
E
S
M
Site 67
S1115
E
S
L
L
F
N
E
S
M
L
W
E
N
A
K
Site 68
T1211
G
G
S
N
I
F
I
T
V
K
Q
R
K
Q
Y
Site 69
Y1218
T
V
K
Q
R
K
Q
Y
R
R
L
K
K
L
M
Site 70
Y1226
R
R
L
K
K
L
M
Y
E
D
S
Q
R
P
V
Site 71
S1229
K
K
L
M
Y
E
D
S
Q
R
P
V
P
R
P
Site 72
S1343
G
S
Y
L
V
P
P
S
L
V
Q
L
I
L
L
Site 73
S1415
E
A
G
I
N
D
V
S
N
F
E
T
F
G
N
Site 74
T1419
N
D
V
S
N
F
E
T
F
G
N
S
M
L
C
Site 75
T1460
P
D
K
I
N
P
G
T
Q
V
R
G
D
C
G
Site 76
T1509
A
S
K
K
K
N
K
T
L
S
E
D
D
F
R
Site 77
S1511
K
K
K
N
K
T
L
S
E
D
D
F
R
K
F
Site 78
T1530
K
R
F
D
P
D
R
T
Q
Y
I
D
S
S
K
Site 79
Y1532
F
D
P
D
R
T
Q
Y
I
D
S
S
K
L
S
Site 80
S1535
D
R
T
Q
Y
I
D
S
S
K
L
S
D
F
A
Site 81
S1536
R
T
Q
Y
I
D
S
S
K
L
S
D
F
A
A
Site 82
S1539
Y
I
D
S
S
K
L
S
D
F
A
A
A
L
D
Site 83
T1619
T
C
E
P
I
T
T
T
L
K
R
K
Q
E
A
Site 84
Y1636
A
T
I
I
Q
R
A
Y
K
N
Y
R
L
R
R
Site 85
Y1639
I
Q
R
A
Y
K
N
Y
R
L
R
R
N
D
K
Site 86
T1648
L
R
R
N
D
K
N
T
S
D
I
H
M
I
D
Site 87
T1663
G
D
R
D
V
H
A
T
K
E
G
A
Y
F
D
Site 88
Y1668
H
A
T
K
E
G
A
Y
F
D
K
A
K
E
K
Site 89
S1676
F
D
K
A
K
E
K
S
P
I
Q
S
Q
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation