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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AML1
Full Name:
Runt-related transcription factor 1
Alias:
Acute myeloid leukemia 1 protein; Aml1 oncogene; AMLCR1; CBFA2; CBF-alpha 2; Core-binding factor subunit alpha-2; Core-binding factor, alpha 2 subunit; Oncogene AML-1; PEA2-alpha B; PEBP2A2; PEBP2-alpha B; Polyomavirus enhancer binding protein 2 alpha B subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; RUNX1; SL3/AKV core-binding factor alpha B subunit; SL3-3 enhancer factor 1 alpha B subunit
Type:
Transcription protein
Mass (Da):
48737
Number AA:
453
UniProt ID:
Q01196
International Prot ID:
IPI00477787
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0030099
GO:0030853
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
I
P
V
D
A
S
T
S
R
R
F
T
P
Site 2
T9
R
I
P
V
D
A
S
T
S
R
R
F
T
P
P
Site 3
S10
I
P
V
D
A
S
T
S
R
R
F
T
P
P
S
Site 4
T14
A
S
T
S
R
R
F
T
P
P
S
T
A
L
S
Site 5
S17
S
R
R
F
T
P
P
S
T
A
L
S
P
G
K
Site 6
T18
R
R
F
T
P
P
S
T
A
L
S
P
G
K
M
Site 7
S21
T
P
P
S
T
A
L
S
P
G
K
M
S
E
A
Site 8
S46
A
L
A
G
K
L
R
S
G
D
R
S
M
V
E
Site 9
S50
K
L
R
S
G
D
R
S
M
V
E
V
L
A
D
Site 10
T65
H
P
G
E
L
V
R
T
D
S
P
N
F
L
C
Site 11
S67
G
E
L
V
R
T
D
S
P
N
F
L
C
S
V
Site 12
Y113
M
A
G
N
D
E
N
Y
S
A
E
L
R
N
A
Site 13
T121
S
A
E
L
R
N
A
T
A
A
M
K
N
Q
V
Site 14
S140
D
L
R
F
V
G
R
S
G
R
G
K
S
F
T
Site 15
S145
G
R
S
G
R
G
K
S
F
T
L
T
I
T
V
Site 16
T149
R
G
K
S
F
T
L
T
I
T
V
F
T
N
P
Site 17
T151
K
S
F
T
L
T
I
T
V
F
T
N
P
P
Q
Site 18
Y162
N
P
P
Q
V
A
T
Y
H
R
A
I
K
I
T
Site 19
T169
Y
H
R
A
I
K
I
T
V
D
G
P
R
E
P
Site 20
T187
R
Q
K
L
D
D
Q
T
K
P
G
S
L
S
F
Site 21
S191
D
D
Q
T
K
P
G
S
L
S
F
S
E
R
L
Site 22
S193
Q
T
K
P
G
S
L
S
F
S
E
R
L
S
E
Site 23
S195
K
P
G
S
L
S
F
S
E
R
L
S
E
L
E
Site 24
S199
L
S
F
S
E
R
L
S
E
L
E
Q
L
R
R
Site 25
T207
E
L
E
Q
L
R
R
T
A
M
R
V
S
P
H
Site 26
S212
R
R
T
A
M
R
V
S
P
H
H
P
A
P
T
Site 27
T219
S
P
H
H
P
A
P
T
P
N
P
R
A
S
L
Site 28
S225
P
T
P
N
P
R
A
S
L
N
H
S
T
A
F
Site 29
S229
P
R
A
S
L
N
H
S
T
A
F
N
P
Q
P
Site 30
T230
R
A
S
L
N
H
S
T
A
F
N
P
Q
P
Q
Site 31
S238
A
F
N
P
Q
P
Q
S
Q
M
Q
D
T
R
Q
Site 32
T243
P
Q
S
Q
M
Q
D
T
R
Q
I
Q
P
S
P
Site 33
S249
D
T
R
Q
I
Q
P
S
P
P
W
S
Y
D
Q
Site 34
S253
I
Q
P
S
P
P
W
S
Y
D
Q
S
Y
Q
Y
Site 35
Y254
Q
P
S
P
P
W
S
Y
D
Q
S
Y
Q
Y
L
Site 36
S257
P
P
W
S
Y
D
Q
S
Y
Q
Y
L
G
S
I
Site 37
Y258
P
W
S
Y
D
Q
S
Y
Q
Y
L
G
S
I
A
Site 38
Y260
S
Y
D
Q
S
Y
Q
Y
L
G
S
I
A
S
P
Site 39
S263
Q
S
Y
Q
Y
L
G
S
I
A
S
P
S
V
H
Site 40
S266
Q
Y
L
G
S
I
A
S
P
S
V
H
P
A
T
Site 41
S268
L
G
S
I
A
S
P
S
V
H
P
A
T
P
I
Site 42
T273
S
P
S
V
H
P
A
T
P
I
S
P
G
R
A
Site 43
S276
V
H
P
A
T
P
I
S
P
G
R
A
S
G
M
Site 44
S281
P
I
S
P
G
R
A
S
G
M
T
T
L
S
A
Site 45
T284
P
G
R
A
S
G
M
T
T
L
S
A
E
L
S
Site 46
T285
G
R
A
S
G
M
T
T
L
S
A
E
L
S
S
Site 47
S291
T
T
L
S
A
E
L
S
S
R
L
S
T
A
P
Site 48
S292
T
L
S
A
E
L
S
S
R
L
S
T
A
P
D
Site 49
S295
A
E
L
S
S
R
L
S
T
A
P
D
L
T
A
Site 50
T296
E
L
S
S
R
L
S
T
A
P
D
L
T
A
F
Site 51
T301
L
S
T
A
P
D
L
T
A
F
S
D
P
R
Q
Site 52
S304
A
P
D
L
T
A
F
S
D
P
R
Q
F
P
A
Site 53
S314
R
Q
F
P
A
L
P
S
I
S
D
P
R
M
H
Site 54
S316
F
P
A
L
P
S
I
S
D
P
R
M
H
Y
P
Site 55
Y322
I
S
D
P
R
M
H
Y
P
G
A
F
T
Y
S
Site 56
T327
M
H
Y
P
G
A
F
T
Y
S
P
T
P
V
T
Site 57
S329
Y
P
G
A
F
T
Y
S
P
T
P
V
T
S
G
Site 58
Y350
A
M
G
S
A
T
R
Y
H
T
Y
L
P
P
P
Site 59
T352
G
S
A
T
R
Y
H
T
Y
L
P
P
P
Y
P
Site 60
Y353
S
A
T
R
Y
H
T
Y
L
P
P
P
Y
P
G
Site 61
Y358
H
T
Y
L
P
P
P
Y
P
G
S
S
Q
A
Q
Site 62
S361
L
P
P
P
Y
P
G
S
S
Q
A
Q
G
G
P
Site 63
S362
P
P
P
Y
P
G
S
S
Q
A
Q
G
G
P
F
Site 64
S372
Q
G
G
P
F
Q
A
S
S
P
S
Y
H
L
Y
Site 65
S373
G
G
P
F
Q
A
S
S
P
S
Y
H
L
Y
Y
Site 66
S375
P
F
Q
A
S
S
P
S
Y
H
L
Y
Y
G
A
Site 67
Y376
F
Q
A
S
S
P
S
Y
H
L
Y
Y
G
A
S
Site 68
Y379
S
S
P
S
Y
H
L
Y
Y
G
A
S
A
G
S
Site 69
Y380
S
P
S
Y
H
L
Y
Y
G
A
S
A
G
S
Y
Site 70
S386
Y
Y
G
A
S
A
G
S
Y
Q
F
S
M
V
G
Site 71
Y387
Y
G
A
S
A
G
S
Y
Q
F
S
M
V
G
G
Site 72
S390
S
A
G
S
Y
Q
F
S
M
V
G
G
E
R
S
Site 73
S397
S
M
V
G
G
E
R
S
P
P
R
I
L
P
P
Site 74
T406
P
R
I
L
P
P
C
T
N
A
S
T
G
S
A
Site 75
S418
G
S
A
L
L
N
P
S
L
P
N
Q
S
D
V
Site 76
S423
N
P
S
L
P
N
Q
S
D
V
V
E
A
E
G
Site 77
S431
D
V
V
E
A
E
G
S
H
S
N
S
P
T
N
Site 78
S433
V
E
A
E
G
S
H
S
N
S
P
T
N
M
A
Site 79
S435
A
E
G
S
H
S
N
S
P
T
N
M
A
P
S
Site 80
T437
G
S
H
S
N
S
P
T
N
M
A
P
S
A
R
Site 81
S442
S
P
T
N
M
A
P
S
A
R
L
E
E
A
V
Site 82
Y453
E
E
A
V
W
R
P
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation