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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AMPD3
Full Name:
AMP deaminase 3
Alias:
Adenosine monophosphate deaminase (isoform E); AMP aminohydrolase; AMP deaminase isoform E; Erythrocyte adenosine monophosphate deaminase; Erythrocyte AMP deaminase; Erythrocyte type AMP deaminase; Erythrocyte-specific AMP deaminase; Myoadenylate deaminase
Type:
Hydrolase; Nucleotide Metabolism - purine; EC 3.5.4.6
Mass (Da):
88794
Number AA:
767
UniProt ID:
Q01432
International Prot ID:
IPI00300573
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003876
PhosphoSite+
KinaseNET
Biological Process:
GO:0006196
GO:0006144
GO:0009168
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
Q
F
P
K
L
N
I
S
E
V
D
E
Q
V
R
Site 2
S34
K
V
L
R
E
E
D
S
K
D
A
L
S
L
F
Site 3
S39
E
D
S
K
D
A
L
S
L
F
T
V
P
E
D
Site 4
S68
K
E
L
A
E
Q
K
S
V
E
T
A
K
R
K
Site 5
S77
E
T
A
K
R
K
K
S
F
K
M
I
R
S
Q
Site 6
S83
K
S
F
K
M
I
R
S
Q
S
L
S
L
Q
M
Site 7
S85
F
K
M
I
R
S
Q
S
L
S
L
Q
M
P
P
Site 8
S87
M
I
R
S
Q
S
L
S
L
Q
M
P
P
Q
Q
Site 9
S103
W
K
G
P
P
A
A
S
P
A
M
S
P
T
T
Site 10
S107
P
A
A
S
P
A
M
S
P
T
T
P
V
V
T
Site 11
T121
T
G
A
T
S
L
P
T
P
A
P
Y
A
M
P
Site 12
Y125
S
L
P
T
P
A
P
Y
A
M
P
E
F
Q
R
Site 13
T134
M
P
E
F
Q
R
V
T
I
S
G
D
Y
C
A
Site 14
Y148
A
G
I
T
L
E
D
Y
E
Q
A
A
K
S
L
Site 15
S154
D
Y
E
Q
A
A
K
S
L
A
K
A
L
M
I
Site 16
Y165
A
L
M
I
R
E
K
Y
A
R
L
A
Y
H
R
Site 17
Y170
E
K
Y
A
R
L
A
Y
H
R
F
P
R
I
T
Site 18
S178
H
R
F
P
R
I
T
S
Q
Y
L
G
H
P
R
Site 19
Y180
F
P
R
I
T
S
Q
Y
L
G
H
P
R
A
D
Site 20
T188
L
G
H
P
R
A
D
T
A
P
P
E
E
G
L
Site 21
Y209
P
L
P
Q
E
D
P
Y
C
L
D
D
A
P
P
Site 22
Y220
D
A
P
P
N
L
D
Y
L
V
H
M
Q
G
G
Site 23
Y232
Q
G
G
I
L
F
V
Y
D
N
K
K
M
L
E
Site 24
S245
L
E
H
Q
E
P
H
S
L
P
Y
P
D
L
E
Site 25
Y248
Q
E
P
H
S
L
P
Y
P
D
L
E
T
Y
T
Site 26
T253
L
P
Y
P
D
L
E
T
Y
T
V
D
M
S
H
Site 27
Y254
P
Y
P
D
L
E
T
Y
T
V
D
M
S
H
I
Site 28
T255
Y
P
D
L
E
T
Y
T
V
D
M
S
H
I
L
Site 29
T272
I
T
D
G
P
T
K
T
Y
C
H
R
R
L
N
Site 30
Y273
T
D
G
P
T
K
T
Y
C
H
R
R
L
N
F
Site 31
S283
R
R
L
N
F
L
E
S
K
F
S
L
H
E
M
Site 32
S286
N
F
L
E
S
K
F
S
L
H
E
M
L
N
E
Site 33
S302
S
E
F
K
E
L
K
S
N
P
H
R
D
F
Y
Site 34
Y309
S
N
P
H
R
D
F
Y
N
V
R
K
V
D
T
Site 35
T336
L
L
R
F
I
K
H
T
Y
Q
T
E
P
D
R
Site 36
T344
Y
Q
T
E
P
D
R
T
V
A
E
K
R
G
R
Site 37
T354
E
K
R
G
R
K
I
T
L
R
Q
V
F
D
G
Site 38
Y367
D
G
L
H
M
D
P
Y
D
L
T
V
D
S
L
Site 39
T370
H
M
D
P
Y
D
L
T
V
D
S
L
D
V
H
Site 40
S373
P
Y
D
L
T
V
D
S
L
D
V
H
A
G
R
Site 41
T382
D
V
H
A
G
R
Q
T
F
H
R
F
D
K
F
Site 42
Y393
F
D
K
F
N
S
K
Y
N
P
V
G
A
S
E
Site 43
Y405
A
S
E
L
R
D
L
Y
L
K
T
E
N
Y
L
Site 44
T408
L
R
D
L
Y
L
K
T
E
N
Y
L
G
G
E
Site 45
Y411
L
Y
L
K
T
E
N
Y
L
G
G
E
Y
F
A
Site 46
Y416
E
N
Y
L
G
G
E
Y
F
A
R
M
V
K
E
Site 47
S431
V
A
R
E
L
E
E
S
K
Y
Q
Y
S
E
P
Site 48
Y433
R
E
L
E
E
S
K
Y
Q
Y
S
E
P
R
L
Site 49
Y435
L
E
E
S
K
Y
Q
Y
S
E
P
R
L
S
I
Site 50
S436
E
E
S
K
Y
Q
Y
S
E
P
R
L
S
I
Y
Site 51
S441
Q
Y
S
E
P
R
L
S
I
Y
G
R
S
P
E
Site 52
Y443
S
E
P
R
L
S
I
Y
G
R
S
P
E
E
W
Site 53
S446
R
L
S
I
Y
G
R
S
P
E
E
W
P
N
L
Site 54
Y477
I
I
Q
V
P
R
I
Y
D
I
F
R
S
K
K
Site 55
T521
H
L
F
L
K
Y
V
T
G
F
D
S
V
D
D
Site 56
S525
K
Y
V
T
G
F
D
S
V
D
D
E
S
K
H
Site 57
S530
F
D
S
V
D
D
E
S
K
H
S
D
H
M
F
Site 58
S533
V
D
D
E
S
K
H
S
D
H
M
F
S
D
K
Site 59
S538
K
H
S
D
H
M
F
S
D
K
S
P
N
P
D
Site 60
S541
D
H
M
F
S
D
K
S
P
N
P
D
V
W
T
Site 61
T548
S
P
N
P
D
V
W
T
S
E
Q
N
P
P
Y
Site 62
S549
P
N
P
D
V
W
T
S
E
Q
N
P
P
Y
S
Site 63
Y555
T
S
E
Q
N
P
P
Y
S
Y
Y
L
Y
Y
M
Site 64
Y558
Q
N
P
P
Y
S
Y
Y
L
Y
Y
M
Y
A
N
Site 65
Y560
P
P
Y
S
Y
Y
L
Y
Y
M
Y
A
N
I
M
Site 66
S579
L
R
R
E
R
G
L
S
T
F
L
F
R
P
H
Site 67
T580
R
R
E
R
G
L
S
T
F
L
F
R
P
H
C
Site 68
S638
M
S
P
L
S
N
N
S
L
F
L
E
Y
S
K
Site 69
S644
N
S
L
F
L
E
Y
S
K
N
P
L
R
E
F
Site 70
S659
L
H
K
G
L
H
V
S
L
S
T
D
D
P
M
Site 71
S661
K
G
L
H
V
S
L
S
T
D
D
P
M
Q
F
Site 72
S704
A
R
N
S
V
L
Q
S
G
L
S
H
Q
E
K
Site 73
S707
S
V
L
Q
S
G
L
S
H
Q
E
K
Q
K
F
Site 74
Y719
Q
K
F
L
G
Q
N
Y
Y
K
E
G
P
E
G
Site 75
Y720
K
F
L
G
Q
N
Y
Y
K
E
G
P
E
G
N
Site 76
T732
E
G
N
D
I
R
K
T
N
V
A
Q
I
R
M
Site 77
Y743
Q
I
R
M
A
F
R
Y
E
T
L
C
N
E
L
Site 78
T745
R
M
A
F
R
Y
E
T
L
C
N
E
L
S
F
Site 79
S751
E
T
L
C
N
E
L
S
F
L
S
D
A
M
K
Site 80
S754
C
N
E
L
S
F
L
S
D
A
M
K
S
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation