KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KRT76
Full Name:
Keratin, type II cytoskeletal 2 oral
Alias:
CK 2P; Cytokeratin 2; Cytokeratin-2P; K22O; K2P; Keratin 2p; KRT2B; KRT2P
Type:
Keratin filament protein
Mass (Da):
65871
Number AA:
638
UniProt ID:
Q01546
International Prot ID:
IPI00008359
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045095
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
R
Q
V
C
K
K
S
F
S
G
R
S
Q
G
Site 2
S11
Q
V
C
K
K
S
F
S
G
R
S
Q
G
F
S
Site 3
S14
K
K
S
F
S
G
R
S
Q
G
F
S
G
R
S
Site 4
S18
S
G
R
S
Q
G
F
S
G
R
S
A
V
V
S
Site 5
S21
S
Q
G
F
S
G
R
S
A
V
V
S
G
S
S
Site 6
S25
S
G
R
S
A
V
V
S
G
S
S
R
M
S
C
Site 7
S31
V
S
G
S
S
R
M
S
C
V
A
R
S
G
G
Site 8
S36
R
M
S
C
V
A
R
S
G
G
A
G
G
G
A
Site 9
S48
G
G
A
C
G
F
R
S
G
A
G
S
F
G
S
Site 10
S52
G
F
R
S
G
A
G
S
F
G
S
R
S
L
Y
Site 11
S55
S
G
A
G
S
F
G
S
R
S
L
Y
N
L
G
Site 12
S57
A
G
S
F
G
S
R
S
L
Y
N
L
G
S
N
Site 13
Y59
S
F
G
S
R
S
L
Y
N
L
G
S
N
K
S
Site 14
S63
R
S
L
Y
N
L
G
S
N
K
S
I
S
I
S
Site 15
S70
S
N
K
S
I
S
I
S
V
A
A
G
S
S
R
Site 16
S86
G
G
F
G
G
G
R
S
S
C
G
F
A
G
G
Site 17
S87
G
F
G
G
G
R
S
S
C
G
F
A
G
G
Y
Site 18
S101
Y
G
G
G
F
G
G
S
Y
G
G
G
F
G
G
Site 19
Y102
G
G
G
F
G
G
S
Y
G
G
G
F
G
G
G
Site 20
S114
G
G
G
R
G
V
G
S
G
F
G
G
A
G
G
Site 21
T189
Q
E
R
E
Q
I
K
T
L
N
N
K
F
A
S
Site 22
S196
T
L
N
N
K
F
A
S
F
I
D
K
V
R
F
Site 23
T223
E
L
L
Q
Q
Q
T
T
G
S
G
P
S
S
L
Site 24
S225
L
Q
Q
Q
T
T
G
S
G
P
S
S
L
E
P
Site 25
S229
T
T
G
S
G
P
S
S
L
E
P
C
F
E
S
Site 26
S247
F
L
C
K
Q
L
D
S
L
L
G
E
R
G
N
Site 27
S261
N
L
E
G
E
L
K
S
M
Q
D
L
V
E
D
Site 28
Y273
V
E
D
F
K
K
K
Y
E
D
E
I
N
K
R
Site 29
S310
E
L
Q
A
K
V
D
S
L
T
D
E
V
S
F
Site 30
T312
Q
A
K
V
D
S
L
T
D
E
V
S
F
L
R
Site 31
S316
D
S
L
T
D
E
V
S
F
L
R
T
L
Y
E
Site 32
T320
D
E
V
S
F
L
R
T
L
Y
E
M
E
L
S
Site 33
S327
T
L
Y
E
M
E
L
S
Q
M
Q
S
H
A
S
Site 34
S331
M
E
L
S
Q
M
Q
S
H
A
S
D
T
S
V
Site 35
S334
S
Q
M
Q
S
H
A
S
D
T
S
V
V
L
S
Site 36
T336
M
Q
S
H
A
S
D
T
S
V
V
L
S
M
D
Site 37
S337
Q
S
H
A
S
D
T
S
V
V
L
S
M
D
N
Site 38
S341
S
D
T
S
V
V
L
S
M
D
N
N
R
C
L
Site 39
Y361
I
A
E
V
R
T
Q
Y
E
E
I
A
Q
R
S
Site 40
S370
E
I
A
Q
R
S
K
S
E
A
E
A
L
Y
Q
Site 41
Y376
K
S
E
A
E
A
L
Y
Q
T
K
L
G
E
L
Site 42
T385
T
K
L
G
E
L
Q
T
T
A
G
R
H
G
D
Site 43
T386
K
L
G
E
L
Q
T
T
A
G
R
H
G
D
D
Site 44
T397
H
G
D
D
L
R
N
T
K
S
E
I
M
E
L
Site 45
S399
D
D
L
R
N
T
K
S
E
I
M
E
L
N
R
Site 46
T427
K
Q
N
A
N
L
Q
T
A
I
A
E
A
E
Q
Site 47
T452
A
K
L
Q
D
L
Q
T
A
L
Q
K
A
K
D
Site 48
Y468
L
A
R
L
L
R
D
Y
Q
E
L
M
N
V
K
Site 49
Y485
L
D
V
E
I
A
T
Y
R
K
L
L
E
G
E
Site 50
S497
E
G
E
E
C
R
M
S
G
E
C
Q
S
A
V
Site 51
S514
S
V
V
S
N
V
T
S
T
S
G
S
S
G
S
Site 52
T515
V
V
S
N
V
T
S
T
S
G
S
S
G
S
S
Site 53
S516
V
S
N
V
T
S
T
S
G
S
S
G
S
S
R
Site 54
S518
N
V
T
S
T
S
G
S
S
G
S
S
R
G
V
Site 55
S519
V
T
S
T
S
G
S
S
G
S
S
R
G
V
F
Site 56
S521
S
T
S
G
S
S
G
S
S
R
G
V
F
G
G
Site 57
S522
T
S
G
S
S
G
S
S
R
G
V
F
G
G
V
Site 58
S530
R
G
V
F
G
G
V
S
G
S
G
S
G
G
Y
Site 59
S532
V
F
G
G
V
S
G
S
G
S
G
G
Y
K
G
Site 60
S534
G
G
V
S
G
S
G
S
G
G
Y
K
G
G
S
Site 61
Y537
S
G
S
G
S
G
G
Y
K
G
G
S
S
S
S
Site 62
S541
S
G
G
Y
K
G
G
S
S
S
S
S
S
S
G
Site 63
S542
G
G
Y
K
G
G
S
S
S
S
S
S
S
G
Y
Site 64
S543
G
Y
K
G
G
S
S
S
S
S
S
S
G
Y
G
Site 65
S544
Y
K
G
G
S
S
S
S
S
S
S
G
Y
G
V
Site 66
S545
K
G
G
S
S
S
S
S
S
S
G
Y
G
V
S
Site 67
S546
G
G
S
S
S
S
S
S
S
G
Y
G
V
S
G
Site 68
S547
G
S
S
S
S
S
S
S
G
Y
G
V
S
G
G
Site 69
Y549
S
S
S
S
S
S
G
Y
G
V
S
G
G
S
G
Site 70
S552
S
S
S
G
Y
G
V
S
G
G
S
G
S
G
Y
Site 71
S555
G
Y
G
V
S
G
G
S
G
S
G
Y
G
G
V
Site 72
S557
G
V
S
G
G
S
G
S
G
Y
G
G
V
S
S
Site 73
Y559
S
G
G
S
G
S
G
Y
G
G
V
S
S
G
S
Site 74
S563
G
S
G
Y
G
G
V
S
S
G
S
T
G
G
R
Site 75
S564
S
G
Y
G
G
V
S
S
G
S
T
G
G
R
G
Site 76
S566
Y
G
G
V
S
S
G
S
T
G
G
R
G
S
S
Site 77
T567
G
G
V
S
S
G
S
T
G
G
R
G
S
S
G
Site 78
S572
G
S
T
G
G
R
G
S
S
G
S
Y
Q
S
S
Site 79
S573
S
T
G
G
R
G
S
S
G
S
Y
Q
S
S
S
Site 80
S575
G
G
R
G
S
S
G
S
Y
Q
S
S
S
S
G
Site 81
Y576
G
R
G
S
S
G
S
Y
Q
S
S
S
S
G
S
Site 82
S578
G
S
S
G
S
Y
Q
S
S
S
S
G
S
R
L
Site 83
S579
S
S
G
S
Y
Q
S
S
S
S
G
S
R
L
G
Site 84
S580
S
G
S
Y
Q
S
S
S
S
G
S
R
L
G
G
Site 85
S581
G
S
Y
Q
S
S
S
S
G
S
R
L
G
G
A
Site 86
S583
Y
Q
S
S
S
S
G
S
R
L
G
G
A
G
S
Site 87
S590
S
R
L
G
G
A
G
S
I
S
V
S
H
S
G
Site 88
S594
G
A
G
S
I
S
V
S
H
S
G
M
G
S
S
Site 89
S596
G
S
I
S
V
S
H
S
G
M
G
S
S
S
G
Site 90
S600
V
S
H
S
G
M
G
S
S
S
G
S
I
Q
T
Site 91
S601
S
H
S
G
M
G
S
S
S
G
S
I
Q
T
S
Site 92
S602
H
S
G
M
G
S
S
S
G
S
I
Q
T
S
G
Site 93
S604
G
M
G
S
S
S
G
S
I
Q
T
S
G
G
S
Site 94
T607
S
S
S
G
S
I
Q
T
S
G
G
S
G
Y
K
Site 95
S608
S
S
G
S
I
Q
T
S
G
G
S
G
Y
K
S
Site 96
S611
S
I
Q
T
S
G
G
S
G
Y
K
S
G
G
G
Site 97
Y613
Q
T
S
G
G
S
G
Y
K
S
G
G
G
G
S
Site 98
S615
S
G
G
S
G
Y
K
S
G
G
G
G
S
T
S
Site 99
S620
Y
K
S
G
G
G
G
S
T
S
I
R
F
S
Q
Site 100
T621
K
S
G
G
G
G
S
T
S
I
R
F
S
Q
T
Site 101
S622
S
G
G
G
G
S
T
S
I
R
F
S
Q
T
T
Site 102
S626
G
S
T
S
I
R
F
S
Q
T
T
S
S
S
Q
Site 103
T628
T
S
I
R
F
S
Q
T
T
S
S
S
Q
H
S
Site 104
T629
S
I
R
F
S
Q
T
T
S
S
S
Q
H
S
S
Site 105
S630
I
R
F
S
Q
T
T
S
S
S
Q
H
S
S
T
Site 106
S631
R
F
S
Q
T
T
S
S
S
Q
H
S
S
T
K
Site 107
S632
F
S
Q
T
T
S
S
S
Q
H
S
S
T
K
_
Site 108
S635
T
T
S
S
S
Q
H
S
S
T
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation