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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DR1
Full Name:
Protein Dr1
Alias:
Down-regulator of transcription 1; Down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2; NC2 beta; NC2-BETA; Negative cofactor 2 beta; TATA-binding protein-associated phosphoprotein; TBAP
Type:
Transcription, coactivator/corepressor
Mass (Da):
19444
Number AA:
176
UniProt ID:
Q01658
International Prot ID:
IPI00008991
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003714
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006350
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
S
S
G
N
D
D
D
Site 2
S5
_
_
_
M
A
S
S
S
G
N
D
D
D
L
T
Site 3
T12
S
G
N
D
D
D
L
T
I
P
R
A
A
I
N
Site 4
S61
A
N
E
I
C
N
K
S
E
K
K
T
I
S
P
Site 5
T65
C
N
K
S
E
K
K
T
I
S
P
E
H
V
I
Site 6
S67
K
S
E
K
K
T
I
S
P
E
H
V
I
Q
A
Site 7
Y83
E
S
L
G
F
G
S
Y
I
S
E
V
K
E
V
Site 8
T96
E
V
L
Q
E
C
K
T
V
A
L
K
R
R
K
Site 9
S105
A
L
K
R
R
K
A
S
S
R
L
E
N
L
G
Site 10
S106
L
K
R
R
K
A
S
S
R
L
E
N
L
G
I
Site 11
S157
Q
A
Q
L
A
A
A
S
A
S
A
S
N
Q
A
Site 12
S159
Q
L
A
A
A
S
A
S
A
S
N
Q
A
G
S
Site 13
S161
A
A
A
S
A
S
A
S
N
Q
A
G
S
S
Q
Site 14
S166
S
A
S
N
Q
A
G
S
S
Q
D
E
E
D
D
Site 15
S167
A
S
N
Q
A
G
S
S
Q
D
E
E
D
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation