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Updated November 2019
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Protein Info
Short Name:
OTUD4
Full Name:
OTU domain-containing protein 4
Alias:
DUBA6; HIV-1 induced protein HIN-1; HSHIN1; KIAA1046; OTU domain containing 4
Type:
Unknown function
Mass (Da):
124045
Number AA:
1114
UniProt ID:
Q01804
International Prot ID:
IPI00399254
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
A
G
P
R
E
D
A
T
P
M
D
A
Y
L
R
Site 2
Y28
D
A
T
P
M
D
A
Y
L
R
K
L
G
L
Y
Site 3
Y35
Y
L
R
K
L
G
L
Y
R
K
L
V
A
K
D
Site 4
S57
V
A
E
Q
V
L
H
S
Q
S
R
H
V
E
V
Site 5
S59
E
Q
V
L
H
S
Q
S
R
H
V
E
V
R
M
Site 6
Y71
V
R
M
A
C
I
H
Y
L
R
E
N
R
E
K
Site 7
S86
F
E
A
F
I
E
G
S
F
E
E
Y
L
K
R
Site 8
Y90
I
E
G
S
F
E
E
Y
L
K
R
L
E
N
P
Site 9
S110
Q
V
E
I
S
A
L
S
L
M
Y
R
K
D
F
Site 10
Y120
Y
R
K
D
F
I
I
Y
R
E
P
N
V
S
P
Site 11
S126
I
Y
R
E
P
N
V
S
P
S
Q
V
T
E
N
Site 12
S128
R
E
P
N
V
S
P
S
Q
V
T
E
N
N
F
Site 13
Y149
C
F
S
N
G
N
H
Y
D
I
V
Y
P
I
K
Site 14
Y153
G
N
H
Y
D
I
V
Y
P
I
K
Y
K
E
S
Site 15
Y157
D
I
V
Y
P
I
K
Y
K
E
S
S
A
M
C
Site 16
S160
Y
P
I
K
Y
K
E
S
S
A
M
C
Q
S
L
Site 17
S161
P
I
K
Y
K
E
S
S
A
M
C
Q
S
L
L
Site 18
S166
E
S
S
A
M
C
Q
S
L
L
Y
E
L
L
Y
Site 19
Y169
A
M
C
Q
S
L
L
Y
E
L
L
Y
E
K
V
Site 20
Y173
S
L
L
Y
E
L
L
Y
E
K
V
F
K
T
D
Site 21
T190
K
I
V
M
E
L
D
T
L
E
V
A
D
E
D
Site 22
S199
E
V
A
D
E
D
N
S
E
I
S
D
S
E
D
Site 23
S202
D
E
D
N
S
E
I
S
D
S
E
D
D
S
C
Site 24
S204
D
N
S
E
I
S
D
S
E
D
D
S
C
K
S
Site 25
S208
I
S
D
S
E
D
D
S
C
K
S
K
T
A
A
Site 26
S211
S
E
D
D
S
C
K
S
K
T
A
A
A
A
A
Site 27
S227
V
N
G
F
K
P
L
S
G
N
E
Q
L
K
N
Site 28
S238
Q
L
K
N
N
G
N
S
T
S
L
P
L
S
R
Site 29
T239
L
K
N
N
G
N
S
T
S
L
P
L
S
R
K
Site 30
S240
K
N
N
G
N
S
T
S
L
P
L
S
R
K
V
Site 31
S244
N
S
T
S
L
P
L
S
R
K
V
L
K
S
L
Site 32
S250
L
S
R
K
V
L
K
S
L
N
P
A
V
Y
R
Site 33
Y256
K
S
L
N
P
A
V
Y
R
N
V
E
Y
E
I
Site 34
Y261
A
V
Y
R
N
V
E
Y
E
I
W
L
K
S
K
Site 35
Y276
Q
A
Q
Q
K
R
D
Y
S
I
A
A
G
L
Q
Site 36
S277
A
Q
Q
K
R
D
Y
S
I
A
A
G
L
Q
Y
Site 37
Y284
S
I
A
A
G
L
Q
Y
E
V
G
D
K
C
Q
Site 38
S336
L
K
A
P
P
P
E
S
W
N
T
V
S
G
K
Site 39
T339
P
P
P
E
S
W
N
T
V
S
G
K
K
M
K
Site 40
S349
G
K
K
M
K
K
P
S
T
S
G
Q
N
F
H
Site 41
T350
K
K
M
K
K
P
S
T
S
G
Q
N
F
H
S
Site 42
S351
K
M
K
K
P
S
T
S
G
Q
N
F
H
S
D
Site 43
S357
T
S
G
Q
N
F
H
S
D
V
D
Y
R
G
P
Site 44
Y361
N
F
H
S
D
V
D
Y
R
G
P
K
N
P
S
Site 45
S368
Y
R
G
P
K
N
P
S
K
P
I
K
A
P
S
Site 46
S375
S
K
P
I
K
A
P
S
A
L
P
P
R
L
Q
Site 47
S385
P
P
R
L
Q
H
P
S
G
V
R
Q
H
A
F
Site 48
S393
G
V
R
Q
H
A
F
S
S
H
S
S
G
S
Q
Site 49
S394
V
R
Q
H
A
F
S
S
H
S
S
G
S
Q
S
Site 50
S396
Q
H
A
F
S
S
H
S
S
G
S
Q
S
Q
K
Site 51
S397
H
A
F
S
S
H
S
S
G
S
Q
S
Q
K
F
Site 52
S399
F
S
S
H
S
S
G
S
Q
S
Q
K
F
S
S
Site 53
S401
S
H
S
S
G
S
Q
S
Q
K
F
S
S
E
H
Site 54
S405
G
S
Q
S
Q
K
F
S
S
E
H
K
N
L
S
Site 55
S406
S
Q
S
Q
K
F
S
S
E
H
K
N
L
S
R
Site 56
S412
S
S
E
H
K
N
L
S
R
T
P
S
Q
I
I
Site 57
T414
E
H
K
N
L
S
R
T
P
S
Q
I
I
R
K
Site 58
S416
K
N
L
S
R
T
P
S
Q
I
I
R
K
P
D
Site 59
T433
R
V
E
D
F
D
H
T
S
R
E
S
N
Y
F
Site 60
S434
V
E
D
F
D
H
T
S
R
E
S
N
Y
F
G
Site 61
S437
F
D
H
T
S
R
E
S
N
Y
F
G
L
S
P
Site 62
Y439
H
T
S
R
E
S
N
Y
F
G
L
S
P
E
E
Site 63
S443
E
S
N
Y
F
G
L
S
P
E
E
R
R
E
K
Site 64
Y460
I
E
E
S
R
L
L
Y
E
I
Q
N
R
D
E
Site 65
S474
E
Q
A
F
P
A
L
S
S
S
S
V
N
Q
S
Site 66
S475
Q
A
F
P
A
L
S
S
S
S
V
N
Q
S
A
Site 67
S476
A
F
P
A
L
S
S
S
S
V
N
Q
S
A
S
Site 68
S477
F
P
A
L
S
S
S
S
V
N
Q
S
A
S
Q
Site 69
S481
S
S
S
S
V
N
Q
S
A
S
Q
S
S
N
P
Site 70
S483
S
S
V
N
Q
S
A
S
Q
S
S
N
P
C
V
Site 71
S485
V
N
Q
S
A
S
Q
S
S
N
P
C
V
Q
R
Site 72
S494
N
P
C
V
Q
R
K
S
S
H
V
G
D
R
K
Site 73
S495
P
C
V
Q
R
K
S
S
H
V
G
D
R
K
G
Site 74
S503
H
V
G
D
R
K
G
S
R
R
R
M
D
T
E
Site 75
T509
G
S
R
R
R
M
D
T
E
E
R
K
D
K
D
Site 76
S517
E
E
R
K
D
K
D
S
I
H
G
H
S
Q
L
Site 77
T532
D
K
R
P
E
P
S
T
L
E
N
I
T
D
D
Site 78
Y541
E
N
I
T
D
D
K
Y
A
T
V
S
S
P
S
Site 79
T543
I
T
D
D
K
Y
A
T
V
S
S
P
S
K
S
Site 80
S545
D
D
K
Y
A
T
V
S
S
P
S
K
S
K
K
Site 81
S546
D
K
Y
A
T
V
S
S
P
S
K
S
K
K
L
Site 82
S548
Y
A
T
V
S
S
P
S
K
S
K
K
L
E
C
Site 83
S550
T
V
S
S
P
S
K
S
K
K
L
E
C
P
S
Site 84
S557
S
K
K
L
E
C
P
S
P
A
E
Q
K
P
A
Site 85
S568
Q
K
P
A
E
H
V
S
L
S
N
P
A
P
L
Site 86
S599
A
T
V
P
A
W
P
S
E
P
T
T
F
G
P
Site 87
T603
A
W
P
S
E
P
T
T
F
G
P
T
G
V
P
Site 88
T607
E
P
T
T
F
G
P
T
G
V
P
A
P
I
P
Site 89
T621
P
V
L
S
V
T
Q
T
L
T
T
G
P
D
S
Site 90
S628
T
L
T
T
G
P
D
S
A
V
S
Q
A
H
L
Site 91
S631
T
G
P
D
S
A
V
S
Q
A
H
L
T
P
S
Site 92
S638
S
Q
A
H
L
T
P
S
P
V
P
V
S
I
Q
Site 93
S643
T
P
S
P
V
P
V
S
I
Q
A
V
N
Q
P
Site 94
T657
P
L
M
P
L
P
Q
T
L
S
L
Y
Q
D
P
Site 95
S659
M
P
L
P
Q
T
L
S
L
Y
Q
D
P
L
Y
Site 96
Y661
L
P
Q
T
L
S
L
Y
Q
D
P
L
Y
P
G
Site 97
Y666
S
L
Y
Q
D
P
L
Y
P
G
F
P
C
N
E
Site 98
Y683
D
R
A
I
V
P
P
Y
S
L
C
Q
T
G
E
Site 99
S684
R
A
I
V
P
P
Y
S
L
C
Q
T
G
E
D
Site 100
T688
P
P
Y
S
L
C
Q
T
G
E
D
L
P
K
D
Site 101
S719
C
P
M
W
A
P
H
S
Y
L
Y
P
L
H
Q
Site 102
Y720
P
M
W
A
P
H
S
Y
L
Y
P
L
H
Q
A
Site 103
Y722
W
A
P
H
S
Y
L
Y
P
L
H
Q
A
Y
L
Site 104
S775
F
P
M
Q
T
E
A
S
V
N
G
Q
M
P
Q
Site 105
S799
S
P
L
V
I
P
P
S
Q
V
S
E
S
H
G
Site 106
S802
V
I
P
P
S
Q
V
S
E
S
H
G
Q
L
S
Site 107
S804
P
P
S
Q
V
S
E
S
H
G
Q
L
S
Y
Q
Site 108
S809
S
E
S
H
G
Q
L
S
Y
Q
A
D
L
E
S
Site 109
Y810
E
S
H
G
Q
L
S
Y
Q
A
D
L
E
S
E
Site 110
S816
S
Y
Q
A
D
L
E
S
E
T
P
G
Q
L
L
Site 111
T818
Q
A
D
L
E
S
E
T
P
G
Q
L
L
H
A
Site 112
Y827
G
Q
L
L
H
A
D
Y
E
E
S
L
S
G
K
Site 113
S830
L
H
A
D
Y
E
E
S
L
S
G
K
N
M
F
Site 114
S832
A
D
Y
E
E
S
L
S
G
K
N
M
F
P
Q
Site 115
S841
K
N
M
F
P
Q
P
S
F
G
P
N
P
F
L
Site 116
S884
R
Q
N
I
V
L
P
S
D
E
K
G
E
L
D
Site 117
S893
E
K
G
E
L
D
L
S
L
E
N
L
D
L
S
Site 118
S900
S
L
E
N
L
D
L
S
K
D
C
G
S
V
S
Site 119
S905
D
L
S
K
D
C
G
S
V
S
T
V
D
E
F
Site 120
S907
S
K
D
C
G
S
V
S
T
V
D
E
F
P
E
Site 121
T908
K
D
C
G
S
V
S
T
V
D
E
F
P
E
A
Site 122
S922
A
R
G
E
H
V
H
S
L
P
E
A
S
V
S
Site 123
S927
V
H
S
L
P
E
A
S
V
S
S
K
P
D
E
Site 124
S929
S
L
P
E
A
S
V
S
S
K
P
D
E
G
R
Site 125
T937
S
K
P
D
E
G
R
T
E
Q
S
S
Q
T
R
Site 126
S941
E
G
R
T
E
Q
S
S
Q
T
R
K
A
D
T
Site 127
T948
S
Q
T
R
K
A
D
T
A
L
A
S
I
P
P
Site 128
T965
E
G
K
A
H
P
P
T
Q
I
L
N
R
E
R
Site 129
T974
I
L
N
R
E
R
E
T
V
P
V
E
L
E
P
Site 130
S987
E
P
K
R
T
I
Q
S
L
K
E
K
T
E
K
Site 131
T1000
E
K
V
K
D
P
K
T
A
A
D
V
V
S
P
Site 132
S1006
K
T
A
A
D
V
V
S
P
G
A
N
S
V
D
Site 133
S1011
V
V
S
P
G
A
N
S
V
D
S
R
V
Q
R
Site 134
S1014
P
G
A
N
S
V
D
S
R
V
Q
R
P
K
E
Site 135
S1023
V
Q
R
P
K
E
E
S
S
E
D
E
N
E
V
Site 136
S1024
Q
R
P
K
E
E
S
S
E
D
E
N
E
V
S
Site 137
S1031
S
E
D
E
N
E
V
S
N
I
L
R
S
G
R
Site 138
S1036
E
V
S
N
I
L
R
S
G
R
S
K
Q
F
Y
Site 139
Y1043
S
G
R
S
K
Q
F
Y
N
Q
T
Y
G
S
R
Site 140
T1046
S
K
Q
F
Y
N
Q
T
Y
G
S
R
K
Y
K
Site 141
Y1047
K
Q
F
Y
N
Q
T
Y
G
S
R
K
Y
K
S
Site 142
Y1052
Q
T
Y
G
S
R
K
Y
K
S
D
W
G
Y
S
Site 143
S1054
Y
G
S
R
K
Y
K
S
D
W
G
Y
S
G
R
Site 144
Y1058
K
Y
K
S
D
W
G
Y
S
G
R
G
G
Y
Q
Site 145
Y1064
G
Y
S
G
R
G
G
Y
Q
H
V
R
S
E
E
Site 146
S1069
G
G
Y
Q
H
V
R
S
E
E
S
W
K
G
Q
Site 147
S1078
E
S
W
K
G
Q
P
S
R
S
R
D
E
G
Y
Site 148
S1080
W
K
G
Q
P
S
R
S
R
D
E
G
Y
Q
Y
Site 149
Y1085
S
R
S
R
D
E
G
Y
Q
Y
H
R
N
V
R
Site 150
Y1087
S
R
D
E
G
Y
Q
Y
H
R
N
V
R
G
R
Site 151
S1103
F
R
G
D
R
R
R
S
G
M
G
D
G
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation