KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PFKP
Full Name:
6-phosphofructokinase type C
Alias:
6-phosphofructokinase type C: Phosphofructokinase 1: Phosphohexokinase: Phosphofructo-1-kinase isozyme C: 6-phosphofructokinase, platelet type: Phosphofructokinase-P: Phosphofructokinase, platelet; 6-phosphofructokinase, platelet type; K6PP; PFK, platelet type; PFK-C; PFKF; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; Phosphofructokinase, platelet; Phosphofructokinase, platelet type; Phosphohexokinase
Type:
Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - galactose; EC 2.7.1.11; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - fructose and mannose; Kinase (non-protein)
Mass (Da):
85596
Number AA:
784
UniProt ID:
Q01813
International Prot ID:
IPI00009790
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005945
Uniprot
OncoNet
Molecular Function:
GO:0003872
GO:0005524
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
A
D
D
S
R
A
P
K
G
S
L
Site 2
S12
D
S
R
A
P
K
G
S
L
R
K
F
L
E
H
Site 3
S21
R
K
F
L
E
H
L
S
G
A
G
K
A
I
G
Site 4
S72
Q
G
M
V
D
G
G
S
N
I
A
E
A
D
W
Site 5
T132
I
G
G
D
G
S
L
T
G
A
N
L
F
R
K
Site 6
S142
N
L
F
R
K
E
W
S
G
L
L
E
E
L
A
Site 7
T211
T
A
Q
S
H
Q
R
T
F
V
L
E
V
M
G
Site 8
S242
D
W
V
F
L
P
E
S
P
P
E
E
G
W
E
Site 9
S257
E
Q
M
C
V
K
L
S
E
N
R
A
R
K
K
Site 10
T294
K
I
K
E
L
V
V
T
Q
L
G
Y
D
T
R
Site 11
T303
L
G
Y
D
T
R
V
T
I
L
G
H
V
Q
R
Site 12
T313
G
H
V
Q
R
G
G
T
P
S
A
F
D
R
I
Site 13
S315
V
Q
R
G
G
T
P
S
A
F
D
R
I
L
A
Site 14
S386
A
V
R
L
R
G
R
S
F
A
G
N
L
N
T
Site 15
T393
S
F
A
G
N
L
N
T
Y
K
R
L
A
I
K
Site 16
T409
P
D
D
Q
I
P
K
T
N
C
N
V
A
V
I
Site 17
Y447
G
H
R
M
L
A
I
Y
D
G
F
D
G
F
A
Site 18
T479
Q
G
G
S
I
L
G
T
K
R
V
L
P
G
K
Site 19
Y487
K
R
V
L
P
G
K
Y
L
E
E
I
A
T
Q
Site 20
T493
K
Y
L
E
E
I
A
T
Q
M
R
T
H
S
I
Site 21
S519
Y
L
G
L
L
E
L
S
A
A
R
E
K
H
E
Site 22
S546
V
S
N
N
V
P
G
S
D
F
S
I
G
A
D
Site 23
T562
A
L
N
T
I
T
D
T
C
D
R
I
K
Q
S
Site 24
T573
I
K
Q
S
A
S
G
T
K
R
R
V
F
I
I
Site 25
Y586
I
I
E
T
M
G
G
Y
C
G
Y
L
A
N
M
Site 26
Y589
T
M
G
G
Y
C
G
Y
L
A
N
M
G
G
L
Site 27
S617
F
D
I
R
D
L
Q
S
N
V
E
H
L
T
E
Site 28
T628
H
L
T
E
K
M
K
T
T
I
Q
R
G
L
V
Site 29
S640
G
L
V
L
R
N
E
S
C
S
E
N
Y
T
T
Site 30
S642
V
L
R
N
E
S
C
S
E
N
Y
T
T
D
F
Site 31
Y645
N
E
S
C
S
E
N
Y
T
T
D
F
I
Y
Q
Site 32
T646
E
S
C
S
E
N
Y
T
T
D
F
I
Y
Q
L
Site 33
Y651
N
Y
T
T
D
F
I
Y
Q
L
Y
S
E
E
G
Site 34
Y654
T
D
F
I
Y
Q
L
Y
S
E
E
G
K
G
V
Site 35
S655
D
F
I
Y
Q
L
Y
S
E
E
G
K
G
V
F
Site 36
S679
M
Q
Q
G
G
A
P
S
P
F
D
R
N
F
G
Site 37
T712
R
G
R
G
K
K
F
T
T
D
D
S
I
C
V
Site 38
T713
G
R
G
K
K
F
T
T
D
D
S
I
C
V
L
Site 39
S767
I
L
A
K
Y
K
A
S
Y
D
V
S
D
S
G
Site 40
Y768
L
A
K
Y
K
A
S
Y
D
V
S
D
S
G
Q
Site 41
S771
Y
K
A
S
Y
D
V
S
D
S
G
Q
L
E
H
Site 42
S773
A
S
Y
D
V
S
D
S
G
Q
L
E
H
V
Q
Site 43
S783
L
E
H
V
Q
P
W
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation