KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ATP2B2
Full Name:
Plasma membrane calcium-transporting ATPase 2
Alias:
AT2B2; ATPase, Ca++ transporting, plasma membrane 2; EC 3.6.3.8; Plasma membrane Ca2+ pump 2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2; PMCA2; PMCA9
Type:
Hydrolase; Cell development/differentiation; Endoplasmic reticulum; EC 3.6.3.8; Transporter
Mass (Da):
136876
Number AA:
1243
UniProt ID:
Q01814
International Prot ID:
IPI00219293
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030165
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006816
GO:0030182
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
D
M
T
N
S
D
F
Y
S
K
N
Q
R
N
E
Site 2
S11
M
T
N
S
D
F
Y
S
K
N
Q
R
N
E
S
Site 3
S18
S
K
N
Q
R
N
E
S
S
H
G
G
E
F
G
Site 4
S19
K
N
Q
R
N
E
S
S
H
G
G
E
F
G
C
Site 5
T27
H
G
G
E
F
G
C
T
M
E
E
L
R
S
L
Site 6
S33
C
T
M
E
E
L
R
S
L
M
E
L
R
G
T
Site 7
T62
A
I
C
R
R
L
K
T
S
P
V
E
G
L
P
Site 8
S63
I
C
R
R
L
K
T
S
P
V
E
G
L
P
G
Site 9
T94
I
P
P
K
K
P
K
T
F
L
Q
L
V
W
E
Site 10
Y124
I
S
L
G
L
S
F
Y
H
P
P
G
E
G
N
Site 11
T136
E
G
N
E
G
C
A
T
A
Q
G
G
A
E
D
Site 12
T193
I
E
Q
E
Q
K
F
T
V
V
R
A
G
Q
V
Site 13
Y218
G
D
I
A
Q
V
K
Y
G
D
L
L
P
A
D
Site 14
S239
N
D
L
K
I
D
E
S
S
L
T
G
E
S
D
Site 15
S240
D
L
K
I
D
E
S
S
L
T
G
E
S
D
Q
Site 16
T242
K
I
D
E
S
S
L
T
G
E
S
D
Q
V
R
Site 17
S245
E
S
S
L
T
G
E
S
D
Q
V
R
K
S
V
Site 18
S251
E
S
D
Q
V
R
K
S
V
D
K
D
P
M
L
Site 19
S260
D
K
D
P
M
L
L
S
G
T
H
V
M
E
G
Site 20
T262
D
P
M
L
L
S
G
T
H
V
M
E
G
S
G
Site 21
S280
V
T
A
V
G
V
N
S
Q
T
G
I
I
F
T
Site 22
T282
A
V
G
V
N
S
Q
T
G
I
I
F
T
L
L
Site 23
S321
A
A
D
G
A
A
A
S
N
A
A
D
S
A
N
Site 24
S326
A
A
S
N
A
A
D
S
A
N
A
S
L
V
N
Site 25
S330
A
A
D
S
A
N
A
S
L
V
N
G
K
M
Q
Site 26
S344
Q
D
G
N
V
D
A
S
Q
S
K
A
K
Q
Q
Site 27
S364
M
E
M
Q
P
L
K
S
A
E
G
G
D
A
D
Site 28
S384
S
M
H
K
K
E
K
S
V
L
Q
G
K
L
T
Site 29
T449
K
F
F
I
I
G
V
T
V
L
V
V
A
V
P
Site 30
Y469
A
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
Site 31
S470
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
D
Site 32
T501
T
A
I
C
S
D
K
T
G
T
L
T
T
N
R
Site 33
T505
S
D
K
T
G
T
L
T
T
N
R
M
T
V
V
Site 34
Y515
R
M
T
V
V
Q
A
Y
V
G
D
V
H
Y
K
Site 35
Y521
A
Y
V
G
D
V
H
Y
K
E
I
P
D
P
S
Site 36
S529
K
E
I
P
D
P
S
S
I
N
T
K
T
M
E
Site 37
T532
P
D
P
S
S
I
N
T
K
T
M
E
L
L
I
Site 38
T550
A
I
N
S
A
Y
T
T
K
I
L
P
P
E
K
Site 39
T569
P
R
Q
V
G
N
K
T
E
C
G
L
L
G
F
Site 40
Y584
V
L
D
L
K
Q
D
Y
E
P
V
R
S
Q
M
Site 41
S589
Q
D
Y
E
P
V
R
S
Q
M
P
E
E
K
L
Site 42
Y597
Q
M
P
E
E
K
L
Y
K
V
Y
T
F
N
S
Site 43
Y600
E
E
K
L
Y
K
V
Y
T
F
N
S
V
R
K
Site 44
T601
E
K
L
Y
K
V
Y
T
F
N
S
V
R
K
S
Site 45
S604
Y
K
V
Y
T
F
N
S
V
R
K
S
M
S
T
Site 46
S608
T
F
N
S
V
R
K
S
M
S
T
V
I
K
L
Site 47
S610
N
S
V
R
K
S
M
S
T
V
I
K
L
P
D
Site 48
T611
S
V
R
K
S
M
S
T
V
I
K
L
P
D
E
Site 49
S619
V
I
K
L
P
D
E
S
F
R
M
Y
S
K
G
Site 50
Y623
P
D
E
S
F
R
M
Y
S
K
G
A
S
E
I
Site 51
S624
D
E
S
F
R
M
Y
S
K
G
A
S
E
I
V
Site 52
S628
R
M
Y
S
K
G
A
S
E
I
V
L
K
K
C
Site 53
S681
V
A
Y
R
D
F
P
S
S
P
E
P
D
W
D
Site 54
S682
A
Y
R
D
F
P
S
S
P
E
P
D
W
D
N
Site 55
T726
K
C
Q
R
A
G
I
T
V
R
M
V
T
G
D
Site 56
S791
K
L
R
V
L
A
R
S
S
P
T
D
K
H
T
Site 57
S792
L
R
V
L
A
R
S
S
P
T
D
K
H
T
L
Site 58
T798
S
S
P
T
D
K
H
T
L
V
K
G
I
I
D
Site 59
S806
L
V
K
G
I
I
D
S
T
H
T
E
Q
R
Q
Site 60
T807
V
K
G
I
I
D
S
T
H
T
E
Q
R
Q
V
Site 61
T822
V
A
V
T
G
D
G
T
N
D
G
P
A
L
K
Site 62
T854
E
A
S
D
I
I
L
T
D
D
N
F
S
S
I
Site 63
S859
I
L
T
D
D
N
F
S
S
I
V
K
A
V
M
Site 64
Y872
V
M
W
G
R
N
V
Y
D
S
I
S
K
F
L
Site 65
S876
R
N
V
Y
D
S
I
S
K
F
L
Q
F
Q
L
Site 66
Y940
T
L
L
L
R
K
P
Y
G
R
N
K
P
L
I
Site 67
S981
E
K
M
F
Q
I
D
S
G
R
N
A
P
L
H
Site 68
S989
G
R
N
A
P
L
H
S
P
P
S
E
H
Y
T
Site 69
S992
A
P
L
H
S
P
P
S
E
H
Y
T
I
I
F
Site 70
T996
S
P
P
S
E
H
Y
T
I
I
F
N
T
F
V
Site 71
S1055
Q
F
G
G
K
P
F
S
C
S
P
L
Q
L
D
Site 72
S1057
G
G
K
P
F
S
C
S
P
L
Q
L
D
Q
W
Site 73
T1099
L
K
E
A
G
R
L
T
Q
K
E
E
I
P
E
Site 74
T1139
R
G
L
N
R
I
Q
T
Q
I
R
V
V
K
A
Site 75
S1149
R
V
V
K
A
F
R
S
S
L
Y
E
G
L
E
Site 76
S1150
V
V
K
A
F
R
S
S
L
Y
E
G
L
E
K
Site 77
Y1152
K
A
F
R
S
S
L
Y
E
G
L
E
K
P
E
Site 78
S1160
E
G
L
E
K
P
E
S
R
T
S
I
H
N
F
Site 79
T1162
L
E
K
P
E
S
R
T
S
I
H
N
F
M
A
Site 80
S1163
E
K
P
E
S
R
T
S
I
H
N
F
M
A
H
Site 81
S1178
P
E
F
R
I
E
D
S
Q
P
H
I
P
L
I
Site 82
T1188
H
I
P
L
I
D
D
T
D
L
E
E
D
A
A
Site 83
S1200
D
A
A
L
K
Q
N
S
S
P
P
S
S
L
N
Site 84
S1201
A
A
L
K
Q
N
S
S
P
P
S
S
L
N
K
Site 85
S1204
K
Q
N
S
S
P
P
S
S
L
N
K
N
N
S
Site 86
S1205
Q
N
S
S
P
P
S
S
L
N
K
N
N
S
A
Site 87
S1211
S
S
L
N
K
N
N
S
A
I
D
S
G
I
N
Site 88
S1215
K
N
N
S
A
I
D
S
G
I
N
L
T
T
D
Site 89
T1220
I
D
S
G
I
N
L
T
T
D
T
S
K
S
A
Site 90
T1223
G
I
N
L
T
T
D
T
S
K
S
A
T
S
S
Site 91
S1224
I
N
L
T
T
D
T
S
K
S
A
T
S
S
S
Site 92
S1226
L
T
T
D
T
S
K
S
A
T
S
S
S
P
G
Site 93
T1228
T
D
T
S
K
S
A
T
S
S
S
P
G
S
P
Site 94
S1229
D
T
S
K
S
A
T
S
S
S
P
G
S
P
I
Site 95
S1230
T
S
K
S
A
T
S
S
S
P
G
S
P
I
H
Site 96
S1231
S
K
S
A
T
S
S
S
P
G
S
P
I
H
S
Site 97
S1234
A
T
S
S
S
P
G
S
P
I
H
S
L
E
T
Site 98
S1238
S
P
G
S
P
I
H
S
L
E
T
S
L
_
_
Site 99
T1241
S
P
I
H
S
L
E
T
S
L
_
_
_
_
_
Site 100
S1242
P
I
H
S
L
E
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation