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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XPC
Full Name:
DNA repair protein complementing XP-C cells
Alias:
DNA repair protein complementing XP-C cells: Xeroderma pigmentosum group C-complementing protein: p125; DNA-repair protein complementing XP-C cells; P125; RAD4; Xeroderma pigmentosum group C complementing protein; Xeroderma pigmentosum group C protein; Xeroderma pigmentosum, complementation group C; XPCC
Type:
DNA repair
Mass (Da):
105981
Number AA:
940
UniProt ID:
Q01831
International Prot ID:
IPI00156793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003684
GO:0005515
GO:0003697
PhosphoSite+
KinaseNET
Biological Process:
GO:0000718
GO:0000077
GO:0000718
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
P
R
G
R
E
L
R
S
Q
K
S
K
A
K
S
Site 2
S21
R
E
L
R
S
Q
K
S
K
A
K
S
K
A
R
Site 3
S25
S
Q
K
S
K
A
K
S
K
A
R
R
E
E
E
Site 4
S46
D
E
K
P
P
K
K
S
L
L
S
K
V
S
Q
Site 5
S49
P
P
K
K
S
L
L
S
K
V
S
Q
G
K
R
Site 6
S52
K
S
L
L
S
K
V
S
Q
G
K
R
K
R
G
Site 7
S61
G
K
R
K
R
G
C
S
H
P
G
G
S
A
D
Site 8
T79
K
K
K
V
A
K
V
T
V
K
S
E
N
L
K
Site 9
S94
V
I
K
D
E
A
L
S
D
G
D
D
L
R
D
Site 10
S104
D
D
L
R
D
F
P
S
D
L
K
K
A
H
H
Site 11
T117
H
H
L
K
R
G
A
T
M
N
E
D
S
N
E
Site 12
S122
G
A
T
M
N
E
D
S
N
E
E
E
E
E
S
Site 13
S129
S
N
E
E
E
E
E
S
E
N
D
W
E
E
V
Site 14
S140
W
E
E
V
E
E
L
S
E
P
V
L
G
D
V
Site 15
S150
V
L
G
D
V
R
E
S
T
A
F
S
R
S
L
Site 16
T151
L
G
D
V
R
E
S
T
A
F
S
R
S
L
L
Site 17
S154
V
R
E
S
T
A
F
S
R
S
L
L
P
V
K
Site 18
S156
E
S
T
A
F
S
R
S
L
L
P
V
K
P
V
Site 19
T169
P
V
E
I
E
I
E
T
P
E
Q
A
K
T
R
Site 20
T175
E
T
P
E
Q
A
K
T
R
E
R
S
E
K
I
Site 21
S179
Q
A
K
T
R
E
R
S
E
K
I
K
L
E
F
Site 22
Y189
I
K
L
E
F
E
T
Y
L
R
R
A
M
K
R
Site 23
T205
N
K
G
V
H
E
D
T
H
K
V
H
L
L
C
Site 24
Y252
L
P
R
D
V
D
T
Y
Y
L
S
N
L
V
K
Site 25
Y253
P
R
D
V
D
T
Y
Y
L
S
N
L
V
K
W
Site 26
S272
F
T
V
N
A
E
L
S
A
S
E
Q
D
N
L
Site 27
S274
V
N
A
E
L
S
A
S
E
Q
D
N
L
Q
T
Site 28
T282
E
Q
D
N
L
Q
T
T
L
E
R
R
F
A
I
Site 29
Y290
L
E
R
R
F
A
I
Y
S
A
R
D
D
E
E
Site 30
S291
E
R
R
F
A
I
Y
S
A
R
D
D
E
E
L
Site 31
S326
L
Q
P
I
P
L
K
S
A
T
A
K
G
K
K
Site 32
S335
T
A
K
G
K
K
P
S
K
E
R
L
T
A
D
Site 33
T340
K
P
S
K
E
R
L
T
A
D
P
G
G
S
S
Site 34
S346
L
T
A
D
P
G
G
S
S
E
T
S
S
Q
V
Site 35
S347
T
A
D
P
G
G
S
S
E
T
S
S
Q
V
L
Site 36
S350
P
G
G
S
S
E
T
S
S
Q
V
L
E
N
H
Site 37
S351
G
G
S
S
E
T
S
S
Q
V
L
E
N
H
T
Site 38
T358
S
Q
V
L
E
N
H
T
K
P
K
T
S
K
G
Site 39
T362
E
N
H
T
K
P
K
T
S
K
G
T
K
Q
E
Site 40
T371
K
G
T
K
Q
E
E
T
F
A
K
G
T
C
R
Site 41
T376
E
E
T
F
A
K
G
T
C
R
P
S
A
K
G
Site 42
S380
A
K
G
T
C
R
P
S
A
K
G
K
R
N
K
Site 43
S394
K
G
G
R
K
K
R
S
K
P
S
S
S
E
E
Site 44
S397
R
K
K
R
S
K
P
S
S
S
E
E
D
E
G
Site 45
S398
K
K
R
S
K
P
S
S
S
E
E
D
E
G
P
Site 46
S399
K
R
S
K
P
S
S
S
E
E
D
E
G
P
G
Site 47
T413
G
D
K
Q
E
K
A
T
Q
R
R
P
H
G
R
Site 48
S426
G
R
E
R
R
V
A
S
R
V
S
Y
K
E
E
Site 49
S429
R
R
V
A
S
R
V
S
Y
K
E
E
S
G
S
Site 50
Y430
R
V
A
S
R
V
S
Y
K
E
E
S
G
S
D
Site 51
S436
S
Y
K
E
E
S
G
S
D
E
A
G
S
G
S
Site 52
S441
S
G
S
D
E
A
G
S
G
S
D
F
E
L
S
Site 53
S443
S
D
E
A
G
S
G
S
D
F
E
L
S
S
G
Site 54
S448
S
G
S
D
F
E
L
S
S
G
E
A
S
D
P
Site 55
S449
G
S
D
F
E
L
S
S
G
E
A
S
D
P
S
Site 56
S453
E
L
S
S
G
E
A
S
D
P
S
D
E
D
S
Site 57
S456
S
G
E
A
S
D
P
S
D
E
D
S
E
P
G
Site 58
S460
S
D
P
S
D
E
D
S
E
P
G
P
P
K
Q
Site 59
T476
K
A
P
A
P
Q
R
T
K
A
G
S
K
S
A
Site 60
S480
P
Q
R
T
K
A
G
S
K
S
A
S
R
T
H
Site 61
S482
R
T
K
A
G
S
K
S
A
S
R
T
H
R
G
Site 62
S484
K
A
G
S
K
S
A
S
R
T
H
R
G
S
H
Site 63
T486
G
S
K
S
A
S
R
T
H
R
G
S
H
R
K
Site 64
S490
A
S
R
T
H
R
G
S
H
R
K
D
P
S
L
Site 65
S496
G
S
H
R
K
D
P
S
L
P
V
A
S
S
S
Site 66
S501
D
P
S
L
P
V
A
S
S
S
S
S
S
S
K
Site 67
S502
P
S
L
P
V
A
S
S
S
S
S
S
S
K
R
Site 68
S503
S
L
P
V
A
S
S
S
S
S
S
S
K
R
G
Site 69
S504
L
P
V
A
S
S
S
S
S
S
S
K
R
G
K
Site 70
S505
P
V
A
S
S
S
S
S
S
S
K
R
G
K
K
Site 71
S506
V
A
S
S
S
S
S
S
S
K
R
G
K
K
M
Site 72
S507
A
S
S
S
S
S
S
S
K
R
G
K
K
M
C
Site 73
S515
K
R
G
K
K
M
C
S
D
G
E
K
A
E
K
Site 74
T557
G
V
V
G
Q
P
L
T
C
Y
K
Y
A
T
K
Site 75
Y559
V
G
Q
P
L
T
C
Y
K
Y
A
T
K
P
M
Site 76
Y561
Q
P
L
T
C
Y
K
Y
A
T
K
P
M
T
Y
Site 77
T567
K
Y
A
T
K
P
M
T
Y
V
V
G
I
D
S
Site 78
Y568
Y
A
T
K
P
M
T
Y
V
V
G
I
D
S
D
Site 79
Y585
V
R
D
V
T
Q
R
Y
D
P
V
W
M
T
V
Site 80
T606
D
A
E
W
W
A
E
T
L
R
P
Y
Q
S
P
Site 81
Y610
W
A
E
T
L
R
P
Y
Q
S
P
F
M
D
R
Site 82
S612
E
T
L
R
P
Y
Q
S
P
F
M
D
R
E
K
Site 83
Y647
L
Y
K
N
H
P
L
Y
A
L
K
R
H
L
L
Site 84
Y656
L
K
R
H
L
L
K
Y
E
A
I
Y
P
E
T
Site 85
Y660
L
L
K
Y
E
A
I
Y
P
E
T
A
A
I
L
Site 86
T663
Y
E
A
I
Y
P
E
T
A
A
I
L
G
Y
C
Site 87
Y669
E
T
A
A
I
L
G
Y
C
R
G
E
A
V
Y
Site 88
Y676
Y
C
R
G
E
A
V
Y
S
R
D
C
V
H
T
Site 89
T689
H
T
L
H
S
R
D
T
W
L
K
K
A
R
V
Site 90
Y704
V
R
L
G
E
V
P
Y
K
M
V
K
G
F
S
Site 91
S711
Y
K
M
V
K
G
F
S
N
R
A
R
K
A
R
Site 92
Y735
N
D
L
G
L
F
G
Y
W
Q
T
E
E
Y
Q
Site 93
Y741
G
Y
W
Q
T
E
E
Y
Q
P
P
V
A
V
D
Site 94
Y803
G
F
D
F
H
G
G
Y
S
H
P
V
T
D
G
Site 95
T808
G
G
Y
S
H
P
V
T
D
G
Y
I
V
C
E
Site 96
Y811
S
H
P
V
T
D
G
Y
I
V
C
E
E
F
K
Site 97
Y865
R
E
R
L
K
R
R
Y
G
P
K
S
E
A
A
Site 98
S869
K
R
R
Y
G
P
K
S
E
A
A
A
P
H
T
Site 99
T876
S
E
A
A
A
P
H
T
D
A
G
G
G
L
S
Site 100
S883
T
D
A
G
G
G
L
S
S
D
E
E
E
G
T
Site 101
S884
D
A
G
G
G
L
S
S
D
E
E
E
G
T
S
Site 102
T890
S
S
D
E
E
E
G
T
S
S
Q
A
E
A
A
Site 103
S891
S
D
E
E
E
G
T
S
S
Q
A
E
A
A
R
Site 104
S892
D
E
E
E
G
T
S
S
Q
A
E
A
A
R
I
Site 105
S903
A
A
R
I
L
A
A
S
W
P
Q
N
R
E
D
Site 106
T923
L
K
G
G
P
K
K
T
K
R
E
K
K
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation