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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OCRL
Full Name:
Inositol polyphosphate 5-phosphatase OCRL-1
Alias:
EC 3.1.3.36; INPP5F; LOCR; Lowe oculocerebrorenal syndrome; NPHL2; OCRL1; Oculocerebrorenal syndrome of Lowe; Phosphatidylinositol polyphosphate 5-phosphatase
Type:
EC 3.1.3.36; Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein)
Mass (Da):
104205
Number AA:
901
UniProt ID:
Q01968
International Prot ID:
IPI00216271
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005795
GO:0005798
Uniprot
OncoNet
Molecular Function:
GO:0004439
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
L
R
E
P
C
A
L
T
L
A
Q
R
N
G
Q
Site 2
S119
L
A
A
Q
K
A
Q
S
Q
L
L
V
P
E
Q
Site 3
S129
L
V
P
E
Q
K
D
S
S
S
W
Y
Q
K
L
Site 4
S131
P
E
Q
K
D
S
S
S
W
Y
Q
K
L
D
T
Site 5
Y133
Q
K
D
S
S
S
W
Y
Q
K
L
D
T
K
D
Site 6
T138
S
W
Y
Q
K
L
D
T
K
D
K
P
S
V
F
Site 7
S143
L
D
T
K
D
K
P
S
V
F
S
G
L
L
G
Site 8
S156
L
G
F
E
D
N
F
S
S
M
N
L
D
K
K
Site 9
S166
N
L
D
K
K
I
N
S
Q
N
Q
P
T
G
I
Site 10
S183
E
P
P
P
P
P
F
S
V
N
K
M
L
P
R
Site 11
S195
L
P
R
E
K
E
A
S
N
K
E
Q
P
K
V
Site 12
T214
R
K
L
F
V
P
N
T
Q
S
G
Q
R
E
G
Site 13
S216
L
F
V
P
N
T
Q
S
G
Q
R
E
G
L
I
Site 14
Y234
L
A
K
R
E
K
E
Y
V
N
I
Q
T
F
R
Site 15
S253
T
W
N
V
N
G
Q
S
P
D
S
G
L
E
P
Site 16
S256
V
N
G
Q
S
P
D
S
G
L
E
P
W
L
N
Site 17
Y272
D
P
N
P
P
D
I
Y
C
I
G
F
Q
E
L
Site 18
Y288
L
S
T
E
A
F
F
Y
F
E
S
V
K
E
Q
Site 19
S298
S
V
K
E
Q
E
W
S
M
A
V
E
R
G
L
Site 20
Y311
G
L
H
S
K
A
K
Y
K
K
V
Q
L
V
R
Site 21
Y335
A
R
K
D
Q
C
R
Y
I
R
D
I
A
T
E
Site 22
T341
R
Y
I
R
D
I
A
T
E
T
V
G
T
G
I
Site 23
T346
I
A
T
E
T
V
G
T
G
I
M
G
K
M
G
Site 24
Y390
F
E
R
R
N
Q
D
Y
K
D
I
C
A
R
M
Site 25
S437
P
D
A
N
E
V
K
S
L
I
N
K
K
D
L
Site 26
Y477
E
I
K
F
I
P
T
Y
K
Y
D
S
K
T
D
Site 27
Y479
K
F
I
P
T
Y
K
Y
D
S
K
T
D
R
W
Site 28
S481
I
P
T
Y
K
Y
D
S
K
T
D
R
W
D
S
Site 29
T483
T
Y
K
Y
D
S
K
T
D
R
W
D
S
S
G
Site 30
S488
S
K
T
D
R
W
D
S
S
G
K
C
R
V
P
Site 31
T521
R
S
H
M
E
L
K
T
S
D
H
K
P
V
S
Site 32
S522
S
H
M
E
L
K
T
S
D
H
K
P
V
S
A
Site 33
S528
T
S
D
H
K
P
V
S
A
L
F
H
I
G
V
Site 34
Y543
K
V
V
D
E
R
R
Y
R
K
V
F
E
D
S
Site 35
S564
M
E
N
D
F
L
P
S
L
E
L
S
R
R
E
Site 36
S568
F
L
P
S
L
E
L
S
R
R
E
F
V
F
E
Site 37
Y610
P
K
L
N
D
S
Q
Y
C
K
P
W
L
R
A
Site 38
Y623
R
A
E
P
F
E
G
Y
L
E
P
N
E
T
V
Site 39
T629
G
Y
L
E
P
N
E
T
V
D
I
S
L
D
V
Site 40
S633
P
N
E
T
V
D
I
S
L
D
V
Y
V
S
K
Site 41
S642
D
V
Y
V
S
K
D
S
V
T
I
L
N
S
G
Site 42
T644
Y
V
S
K
D
S
V
T
I
L
N
S
G
E
D
Site 43
Y667
H
L
D
R
G
K
D
Y
F
L
T
I
S
G
N
Site 44
T670
R
G
K
D
Y
F
L
T
I
S
G
N
Y
L
P
Site 45
S672
K
D
Y
F
L
T
I
S
G
N
Y
L
P
S
C
Site 46
T700
P
I
R
E
V
P
V
T
K
L
I
D
L
E
E
Site 47
S709
L
I
D
L
E
E
D
S
F
L
E
K
E
K
S
Site 48
S728
V
P
L
D
E
G
A
S
E
R
P
L
Q
V
P
Site 49
Y748
L
V
D
H
L
F
K
Y
A
C
H
Q
E
D
L
Site 50
T758
H
Q
E
D
L
F
Q
T
P
G
M
Q
E
E
L
Site 51
T779
L
D
T
S
I
P
E
T
I
P
G
S
N
H
S
Site 52
S783
I
P
E
T
I
P
G
S
N
H
S
V
A
E
A
Site 53
Y816
Q
R
C
L
D
S
A
Y
D
P
R
I
C
R
Q
Site 54
Y838
C
H
R
N
V
F
R
Y
L
M
A
F
L
R
E
Site 55
S850
L
R
E
L
L
K
F
S
E
Y
N
S
V
N
A
Site 56
Y852
E
L
L
K
F
S
E
Y
N
S
V
N
A
N
M
Site 57
S854
L
K
F
S
E
Y
N
S
V
N
A
N
M
I
A
Site 58
T880
P
N
L
M
A
R
Q
T
P
S
D
R
Q
R
A
Site 59
S882
L
M
A
R
Q
T
P
S
D
R
Q
R
A
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation