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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKCe
Full Name:
Protein kinase C epsilon type
Alias:
EC 2.7.11.13; KPCE; NPKC-epsilon; PKCEA; PKC-epsilon; PRKC
Type:
Protein-serine kinase, AGC group, PKC family, Eta subfamily
Mass (Da):
83674
Number AA:
737
UniProt ID:
Q02156
International Prot ID:
IPI00024539
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0019899
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006917
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
PKCE/ZSubtide - PKCe (PRKCE) protein kinase substrate peptide - Powder PE-01BIT95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIT95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
E
A
V
S
L
K
P
T
A
W
S
L
R
H
A
Site 2
S24
S
L
K
P
T
A
W
S
L
R
H
A
V
G
P
Site 3
S49
I
A
L
N
V
D
D
S
R
I
G
Q
T
A
T
Site 4
T60
Q
T
A
T
K
Q
K
T
N
S
P
A
W
H
D
Site 5
S62
A
T
K
Q
K
T
N
S
P
A
W
H
D
E
F
Site 6
S110
E
E
L
L
Q
N
G
S
R
H
F
E
D
W
I
Site 7
S132
V
Y
V
I
I
D
L
S
G
S
S
G
E
A
P
Site 8
S134
V
I
I
D
L
S
G
S
S
G
E
A
P
K
D
Site 9
S135
I
I
D
L
S
G
S
S
G
E
A
P
K
D
N
Site 10
T175
N
G
H
K
F
M
A
T
Y
L
R
Q
P
T
Y
Site 11
Y176
G
H
K
F
M
A
T
Y
L
R
Q
P
T
Y
C
Site 12
T181
A
T
Y
L
R
Q
P
T
Y
C
S
H
C
R
D
Site 13
Y182
T
Y
L
R
Q
P
T
Y
C
S
H
C
R
D
F
Site 14
T218
R
C
H
E
L
I
I
T
K
C
A
G
L
K
K
Site 15
T228
A
G
L
K
K
Q
E
T
P
D
Q
V
G
S
Q
Site 16
S234
E
T
P
D
Q
V
G
S
Q
R
F
S
V
N
M
Site 17
S238
Q
V
G
S
Q
R
F
S
V
N
M
P
H
K
F
Site 18
Y250
H
K
F
G
I
H
N
Y
K
V
P
T
F
C
D
Site 19
T286
N
V
H
R
R
C
E
T
N
V
A
P
N
C
G
Site 20
T309
V
L
A
D
L
G
V
T
P
D
K
I
T
N
S
Site 21
T314
G
V
T
P
D
K
I
T
N
S
G
Q
R
R
K
Site 22
S316
T
P
D
K
I
T
N
S
G
Q
R
R
K
K
L
Site 23
S329
K
L
I
A
G
A
E
S
P
Q
P
A
S
G
S
Site 24
S334
A
E
S
P
Q
P
A
S
G
S
S
P
S
E
E
Site 25
S336
S
P
Q
P
A
S
G
S
S
P
S
E
E
D
R
Site 26
S337
P
Q
P
A
S
G
S
S
P
S
E
E
D
R
S
Site 27
S339
P
A
S
G
S
S
P
S
E
E
D
R
S
K
S
Site 28
S344
S
P
S
E
E
D
R
S
K
S
A
P
T
S
P
Site 29
S346
S
E
E
D
R
S
K
S
A
P
T
S
P
C
D
Site 30
T349
D
R
S
K
S
A
P
T
S
P
C
D
Q
E
I
Site 31
S350
R
S
K
S
A
P
T
S
P
C
D
Q
E
I
K
Site 32
S368
N
N
I
R
K
A
L
S
F
D
N
R
G
E
E
Site 33
S380
G
E
E
H
R
A
A
S
S
P
D
G
Q
L
M
Site 34
S381
E
E
H
R
A
A
S
S
P
D
G
Q
L
M
S
Site 35
S388
S
P
D
G
Q
L
M
S
P
G
E
N
G
E
V
Site 36
S418
I
K
V
L
G
K
G
S
F
G
K
V
M
L
A
Site 37
Y434
L
K
G
K
D
E
V
Y
A
V
K
V
L
K
K
Site 38
T453
Q
D
D
D
V
D
C
T
M
T
E
K
R
I
L
Site 39
T455
D
D
V
D
C
T
M
T
E
K
R
I
L
A
L
Site 40
Y468
A
L
A
R
K
H
P
Y
L
T
Q
L
Y
C
C
Site 41
Y473
H
P
Y
L
T
Q
L
Y
C
C
F
Q
T
K
D
Site 42
Y488
R
L
F
F
V
M
E
Y
V
N
G
G
D
L
M
Site 43
S509
R
K
F
D
E
P
R
S
R
F
Y
A
A
E
V
Site 44
Y512
D
E
P
R
S
R
F
Y
A
A
E
V
T
S
A
Site 45
T517
R
F
Y
A
A
E
V
T
S
A
L
M
F
L
H
Site 46
T563
E
G
I
L
N
G
V
T
T
T
T
F
C
G
T
Site 47
T564
G
I
L
N
G
V
T
T
T
T
F
C
G
T
P
Site 48
T565
I
L
N
G
V
T
T
T
T
F
C
G
T
P
D
Site 49
T566
L
N
G
V
T
T
T
T
F
C
G
T
P
D
Y
Site 50
T570
T
T
T
T
F
C
G
T
P
D
Y
I
A
P
E
Site 51
Y573
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
Q
Site 52
Y584
E
I
L
Q
E
L
E
Y
G
P
S
V
D
W
W
Site 53
Y626
I
L
H
D
D
V
L
Y
P
V
W
L
S
K
E
Site 54
S636
W
L
S
K
E
A
V
S
I
L
K
A
F
M
T
Site 55
T643
S
I
L
K
A
F
M
T
K
N
P
H
K
R
L
Site 56
S655
K
R
L
G
C
V
A
S
Q
N
G
E
D
A
I
Site 57
T691
P
F
K
P
R
I
K
T
K
R
D
V
N
N
F
Site 58
T703
N
N
F
D
Q
D
F
T
R
E
E
P
V
L
T
Site 59
T710
T
R
E
E
P
V
L
T
L
V
D
E
A
I
V
Site 60
S729
Q
E
E
F
K
G
F
S
Y
F
G
E
D
L
M
Site 61
Y730
E
E
F
K
G
F
S
Y
F
G
E
D
L
M
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation