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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OGDH
Full Name:
2-oxoglutarate dehydrogenase, mitochondrial
Alias:
2-oxoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase E1, mitochondrial; AKGDH; Alpha-ketoglutarate dehydrogenase; E1k; EC 1.2.4.2; ODO1; OGDC; Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); Oxoglutarate dehydrogenase (lipoamide); Oxoglutarate dehydrogenase (succinyl-transferring)
Type:
EC 1.2.4.2; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - lysine degradation
Mass (Da):
115935
Number AA:
1023
UniProt ID:
Q02218
International Prot ID:
IPI00098902
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0031966
Uniprot
OncoNet
Molecular Function:
GO:0004591
GO:0030976
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
A
A
K
L
R
P
L
T
A
S
Q
T
V
K
T
Site 2
S17
K
L
R
P
L
T
A
S
Q
T
V
K
T
F
S
Site 3
T19
R
P
L
T
A
S
Q
T
V
K
T
F
S
Q
N
Site 4
T22
T
A
S
Q
T
V
K
T
F
S
Q
N
R
P
A
Site 5
S24
S
Q
T
V
K
T
F
S
Q
N
R
P
A
A
A
Site 6
T33
N
R
P
A
A
A
R
T
F
Q
Q
I
R
C
Y
Site 7
Y40
T
F
Q
Q
I
R
C
Y
S
A
P
V
A
A
E
Site 8
S41
F
Q
Q
I
R
C
Y
S
A
P
V
A
A
E
P
Site 9
S55
P
F
L
S
G
T
S
S
N
Y
V
E
E
M
Y
Site 10
Y57
L
S
G
T
S
S
N
Y
V
E
E
M
Y
C
A
Site 11
Y62
S
N
Y
V
E
E
M
Y
C
A
W
L
E
N
P
Site 12
T91
N
A
G
A
P
P
G
T
A
Y
Q
S
P
L
P
Site 13
Y93
G
A
P
P
G
T
A
Y
Q
S
P
L
P
L
S
Site 14
S95
P
P
G
T
A
Y
Q
S
P
L
P
L
S
R
G
Site 15
S132
E
D
H
L
A
V
Q
S
L
I
R
A
Y
Q
I
Site 16
Y137
V
Q
S
L
I
R
A
Y
Q
I
R
G
H
H
V
Site 17
Y175
S
T
D
K
L
G
F
Y
G
L
D
E
S
D
L
Site 18
S180
G
F
Y
G
L
D
E
S
D
L
D
K
V
F
H
Site 19
T191
K
V
F
H
L
P
T
T
T
F
I
G
G
Q
E
Site 20
Y214
I
R
R
L
E
M
A
Y
C
Q
H
I
G
V
E
Site 21
T253
F
T
N
E
E
K
R
T
L
L
A
R
L
V
R
Site 22
T262
L
A
R
L
V
R
S
T
R
F
E
E
F
L
Q
Site 23
S273
E
F
L
Q
R
K
W
S
S
E
K
R
F
G
L
Site 24
S274
F
L
Q
R
K
W
S
S
E
K
R
F
G
L
E
Site 25
S297
L
K
T
I
I
D
K
S
S
E
N
G
V
D
Y
Site 26
S298
K
T
I
I
D
K
S
S
E
N
G
V
D
Y
V
Site 27
Y304
S
S
E
N
G
V
D
Y
V
I
M
G
M
P
H
Site 28
Y349
E
G
S
G
D
V
K
Y
H
L
G
M
Y
H
R
Site 29
Y354
V
K
Y
H
L
G
M
Y
H
R
R
I
N
R
V
Site 30
T362
H
R
R
I
N
R
V
T
D
R
N
I
T
L
S
Site 31
T367
R
V
T
D
R
N
I
T
L
S
L
V
A
N
P
Site 32
S369
T
D
R
N
I
T
L
S
L
V
A
N
P
S
H
Site 33
S375
L
S
L
V
A
N
P
S
H
L
E
A
A
D
P
Site 34
Y394
K
T
K
A
E
Q
F
Y
C
G
D
T
E
G
K
Site 35
T398
E
Q
F
Y
C
G
D
T
E
G
K
K
V
M
S
Site 36
T423
G
Q
G
I
V
Y
E
T
F
H
L
S
D
L
P
Site 37
S427
V
Y
E
T
F
H
L
S
D
L
P
S
Y
T
T
Site 38
S431
F
H
L
S
D
L
P
S
Y
T
T
H
G
T
V
Site 39
Y432
H
L
S
D
L
P
S
Y
T
T
H
G
T
V
H
Site 40
T433
L
S
D
L
P
S
Y
T
T
H
G
T
V
H
V
Site 41
T437
P
S
Y
T
T
H
G
T
V
H
V
V
V
N
N
Site 42
S458
D
P
R
M
A
R
S
S
P
Y
P
T
D
V
A
Site 43
Y460
R
M
A
R
S
S
P
Y
P
T
D
V
A
R
V
Site 44
T462
A
R
S
S
P
Y
P
T
D
V
A
R
V
V
N
Site 45
S477
A
P
I
F
H
V
N
S
D
D
P
E
A
V
M
Site 46
T496
V
A
A
E
W
R
S
T
F
H
K
D
V
V
V
Site 47
Y508
V
V
V
D
L
V
C
Y
R
R
N
G
H
N
E
Site 48
T522
E
M
D
E
P
M
F
T
Q
P
L
M
Y
K
Q
Site 49
Y527
M
F
T
Q
P
L
M
Y
K
Q
I
R
K
Q
K
Site 50
Y540
Q
K
P
V
L
Q
K
Y
A
E
L
L
V
S
Q
Site 51
S546
K
Y
A
E
L
L
V
S
Q
G
V
V
N
Q
P
Site 52
Y555
G
V
V
N
Q
P
E
Y
E
E
E
I
S
K
Y
Site 53
S560
P
E
Y
E
E
E
I
S
K
Y
D
K
I
C
E
Site 54
Y562
Y
E
E
E
I
S
K
Y
D
K
I
C
E
E
A
Site 55
T594
S
P
W
P
G
F
F
T
L
D
G
Q
P
R
S
Site 56
S601
T
L
D
G
Q
P
R
S
M
S
C
P
S
T
G
Site 57
S603
D
G
Q
P
R
S
M
S
C
P
S
T
G
L
T
Site 58
T607
R
S
M
S
C
P
S
T
G
L
T
E
D
I
L
Site 59
S623
H
I
G
N
V
A
S
S
V
P
V
E
N
F
T
Site 60
T630
S
V
P
V
E
N
F
T
I
H
G
G
L
S
R
Site 61
S636
F
T
I
H
G
G
L
S
R
I
L
K
T
R
G
Site 62
T650
G
E
M
V
K
N
R
T
V
D
W
A
L
A
E
Site 63
S674
E
G
I
H
I
R
L
S
G
Q
D
V
E
R
G
Site 64
T682
G
Q
D
V
E
R
G
T
F
S
H
R
H
H
V
Site 65
T699
D
Q
N
V
D
K
R
T
C
I
P
M
N
H
L
Site 66
Y713
L
W
P
N
Q
A
P
Y
T
V
C
N
S
S
L
Site 67
T714
W
P
N
Q
A
P
Y
T
V
C
N
S
S
L
S
Site 68
S719
P
Y
T
V
C
N
S
S
L
S
E
Y
G
V
L
Site 69
S721
T
V
C
N
S
S
L
S
E
Y
G
V
L
G
F
Site 70
S791
E
G
M
G
P
E
H
S
S
A
R
P
E
R
F
Site 71
S792
G
M
G
P
E
H
S
S
A
R
P
E
R
F
L
Site 72
Y823
N
F
D
I
N
Q
L
Y
D
C
N
W
V
V
V
Site 73
T858
R
K
P
L
I
I
F
T
P
K
S
L
L
R
H
Site 74
S871
R
H
P
E
A
R
S
S
F
D
E
M
L
P
G
Site 75
T913
G
K
V
Y
Y
D
L
T
R
E
R
K
A
R
D
Site 76
T928
M
V
G
Q
V
A
I
T
R
I
E
Q
L
S
P
Site 77
Y948
L
L
K
E
V
Q
K
Y
P
N
A
E
L
A
W
Site 78
Y965
E
E
H
K
N
Q
G
Y
Y
D
Y
V
K
P
R
Site 79
Y966
E
H
K
N
Q
G
Y
Y
D
Y
V
K
P
R
L
Site 80
Y968
K
N
Q
G
Y
Y
D
Y
V
K
P
R
L
R
T
Site 81
T975
Y
V
K
P
R
L
R
T
T
I
S
R
A
K
P
Site 82
T976
V
K
P
R
L
R
T
T
I
S
R
A
K
P
V
Site 83
S978
P
R
L
R
T
T
I
S
R
A
K
P
V
W
Y
Site 84
Y985
S
R
A
K
P
V
W
Y
A
G
R
D
P
A
A
Site 85
T996
D
P
A
A
A
P
A
T
G
N
K
K
T
H
L
Site 86
T1004
G
N
K
K
T
H
L
T
E
L
Q
R
L
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation