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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH6A1
Full Name:
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Alias:
Aldehyde dehydrogenase family 6 member A1
Type:
Mass (Da):
57840
Number AA:
535
UniProt ID:
Q02252
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
R
A
R
I
L
Q
V
S
S
K
V
K
S
S
P
Site 2
S19
A
R
I
L
Q
V
S
S
K
V
K
S
S
P
T
Site 3
S23
Q
V
S
S
K
V
K
S
S
P
T
W
Y
S
A
Site 4
S24
V
S
S
K
V
K
S
S
P
T
W
Y
S
A
S
Site 5
T26
S
K
V
K
S
S
P
T
W
Y
S
A
S
S
F
Site 6
Y28
V
K
S
S
P
T
W
Y
S
A
S
S
F
S
S
Site 7
S29
K
S
S
P
T
W
Y
S
A
S
S
F
S
S
S
Site 8
S31
S
P
T
W
Y
S
A
S
S
F
S
S
S
V
P
Site 9
S32
P
T
W
Y
S
A
S
S
F
S
S
S
V
P
T
Site 10
S35
Y
S
A
S
S
F
S
S
S
V
P
T
V
K
L
Site 11
S51
I
G
G
K
F
V
E
S
K
S
D
K
W
I
D
Site 12
S53
G
K
F
V
E
S
K
S
D
K
W
I
D
I
H
Site 13
T64
I
D
I
H
N
P
A
T
N
E
V
I
G
R
V
Site 14
T75
I
G
R
V
P
Q
A
T
K
A
E
M
D
A
A
Site 15
T96
A
F
P
A
W
A
D
T
S
V
L
S
R
Q
Q
Site 16
S97
F
P
A
W
A
D
T
S
V
L
S
R
Q
Q
V
Site 17
T130
I
T
L
E
Q
G
K
T
L
A
D
A
E
G
D
Site 18
Y170
I
T
K
D
M
D
L
Y
S
Y
R
L
P
L
G
Site 19
S171
T
K
D
M
D
L
Y
S
Y
R
L
P
L
G
V
Site 20
Y172
K
D
M
D
L
Y
S
Y
R
L
P
L
G
V
C
Site 21
S211
N
T
F
L
M
K
P
S
E
R
V
P
G
A
T
Site 22
S228
L
A
K
L
L
Q
D
S
G
A
P
D
G
T
L
Site 23
T234
D
S
G
A
P
D
G
T
L
N
I
I
H
G
Q
Site 24
S258
H
P
D
I
K
A
I
S
F
V
G
S
N
K
A
Site 25
S262
K
A
I
S
F
V
G
S
N
K
A
G
E
Y
I
Site 26
Y268
G
S
N
K
A
G
E
Y
I
F
E
R
G
S
R
Site 27
S274
E
Y
I
F
E
R
G
S
R
H
G
K
R
V
Q
Site 28
T360
A
D
L
G
P
L
I
T
P
Q
A
K
E
R
V
Site 29
S373
R
V
C
N
L
I
D
S
G
T
K
E
G
A
S
Site 30
T375
C
N
L
I
D
S
G
T
K
E
G
A
S
I
L
Site 31
S380
S
G
T
K
E
G
A
S
I
L
L
D
G
R
K
Site 32
Y393
R
K
I
K
V
K
G
Y
E
N
G
N
F
V
G
Site 33
Y414
V
K
P
N
M
T
C
Y
K
E
E
I
F
G
P
Site 34
Y443
Q
I
V
N
N
N
P
Y
G
N
G
T
A
I
F
Site 35
Y460
N
G
A
T
A
R
K
Y
A
H
L
V
D
V
G
Site 36
S483
P
V
P
L
P
M
F
S
F
T
G
S
R
S
S
Site 37
T485
P
L
P
M
F
S
F
T
G
S
R
S
S
F
R
Site 38
S487
P
M
F
S
F
T
G
S
R
S
S
F
R
G
D
Site 39
S489
F
S
F
T
G
S
R
S
S
F
R
G
D
T
N
Site 40
S490
S
F
T
G
S
R
S
S
F
R
G
D
T
N
F
Site 41
T495
R
S
S
F
R
G
D
T
N
F
Y
G
K
Q
G
Site 42
Y498
F
R
G
D
T
N
F
Y
G
K
Q
G
I
Q
F
Site 43
S514
T
Q
L
K
T
I
T
S
Q
W
K
E
E
D
A
Site 44
T522
Q
W
K
E
E
D
A
T
L
S
S
P
A
V
V
Site 45
S524
K
E
E
D
A
T
L
S
S
P
A
V
V
M
P
Site 46
S525
E
E
D
A
T
L
S
S
P
A
V
V
M
P
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation