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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP27A1
Full Name:
Sterol 26-hydroxylase, mitochondrial
Alias:
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase;Cytochrome P-450C27/25;Cytochrome P450 27;Sterol 27-hydroxylase;Vitamin D(3) 25-hydroxylase
Type:
Mass (Da):
60235
Number AA:
531
UniProt ID:
Q02318
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T41
A
L
P
S
D
K
A
T
G
A
P
G
A
G
P
Site 2
S56
G
V
R
R
R
Q
R
S
L
E
E
I
P
R
L
Site 3
Y88
L
H
Q
L
Q
V
L
Y
K
A
K
Y
G
P
M
Site 4
Y92
Q
V
L
Y
K
A
K
Y
G
P
M
W
M
S
Y
Site 5
Y124
V
M
R
Q
E
G
K
Y
P
V
R
N
D
M
E
Site 6
T143
H
R
D
Q
H
D
L
T
Y
G
P
F
T
T
E
Site 7
Y144
R
D
Q
H
D
L
T
Y
G
P
F
T
T
E
G
Site 8
Y155
T
T
E
G
H
H
W
Y
Q
L
R
Q
A
L
N
Site 9
Y174
K
P
A
E
A
A
L
Y
T
D
A
F
N
E
V
Site 10
S196
L
D
Q
L
R
A
E
S
A
S
G
N
Q
V
S
Site 11
S198
Q
L
R
A
E
S
A
S
G
N
Q
V
S
D
M
Site 12
S203
S
A
S
G
N
Q
V
S
D
M
A
Q
L
F
Y
Site 13
S232
R
I
G
C
L
Q
R
S
I
P
E
D
T
V
T
Site 14
T237
Q
R
S
I
P
E
D
T
V
T
F
V
R
S
I
Site 15
T255
F
Q
N
S
L
Y
A
T
F
L
P
K
W
T
R
Site 16
Y271
V
L
P
F
W
K
R
Y
L
D
G
W
N
A
I
Site 17
S317
Y
L
H
F
L
L
A
S
G
Q
L
S
P
R
E
Site 18
S321
L
L
A
S
G
Q
L
S
P
R
E
A
M
G
S
Site 19
S328
S
P
R
E
A
M
G
S
L
P
E
L
L
M
A
Site 20
T343
G
V
D
T
T
S
N
T
L
T
W
A
L
Y
H
Site 21
T345
D
T
T
S
N
T
L
T
W
A
L
Y
H
L
S
Site 22
Y349
N
T
L
T
W
A
L
Y
H
L
S
K
D
P
E
Site 23
S352
T
W
A
L
Y
H
L
S
K
D
P
E
I
Q
E
Site 24
Y397
L
K
E
T
L
R
L
Y
P
V
V
P
T
N
S
Site 25
Y429
T
Q
F
V
F
C
H
Y
V
V
S
R
D
P
T
Site 26
T436
Y
V
V
S
R
D
P
T
A
F
S
E
P
E
S
Site 27
S439
S
R
D
P
T
A
F
S
E
P
E
S
F
Q
P
Site 28
S443
T
A
F
S
E
P
E
S
F
Q
P
H
R
W
L
Site 29
S453
P
H
R
W
L
R
N
S
Q
P
A
T
P
R
I
Site 30
T457
L
R
N
S
Q
P
A
T
P
R
I
Q
H
P
F
Site 31
S466
R
I
Q
H
P
F
G
S
V
P
F
G
Y
G
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation