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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APBA1
Full Name:
Amyloid beta A4 precursor protein-binding family A member 1
Alias:
Adapter protein X11alpha; Amyloid beta (A4) precursor protein-binding, family A, member 1; Amyloid beta A4-binding family A member 1; D9S411E; Mint- 1; MINT1; Neuron- specific X11; Neuronal Munc18-1-interacting protein 1; Neuron-specific X11 protein; X11
Type:
Adaptor/scaffold
Mass (Da):
92865
Number AA:
837
UniProt ID:
Q02410
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008088
GO:0007155
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
G
S
A
E
V
E
V
T
D
E
A
A
G
G
E
Site 2
S24
A
G
G
E
V
N
E
S
V
E
A
D
L
E
H
Site 3
Y47
Q
P
P
Q
Q
Q
H
Y
V
G
R
H
Q
R
G
Site 4
S78
R
G
E
C
L
A
R
S
A
S
T
E
S
G
F
Site 5
S80
E
C
L
A
R
S
A
S
T
E
S
G
F
H
N
Site 6
S83
A
R
S
A
S
T
E
S
G
F
H
N
H
T
D
Site 7
T89
E
S
G
F
H
N
H
T
D
T
A
E
G
D
V
Site 8
T91
G
F
H
N
H
T
D
T
A
E
G
D
V
I
A
Site 9
Y104
I
A
A
A
R
D
G
Y
D
A
E
R
A
Q
D
Site 10
Y118
D
P
E
D
E
S
A
Y
A
V
Q
Y
R
P
E
Site 11
Y122
E
S
A
Y
A
V
Q
Y
R
P
E
A
E
E
Y
Site 12
Y129
Y
R
P
E
A
E
E
Y
T
E
Q
A
E
A
E
Site 13
T141
E
A
E
H
A
E
A
T
H
R
R
A
L
P
N
Site 14
S154
P
N
H
L
H
F
H
S
L
E
H
E
E
A
M
Site 15
Y165
E
E
A
M
N
A
A
Y
S
G
Y
V
Y
T
H
Site 16
S166
E
A
M
N
A
A
Y
S
G
Y
V
Y
T
H
R
Site 17
Y168
M
N
A
A
Y
S
G
Y
V
Y
T
H
R
L
F
Site 18
Y170
A
A
Y
S
G
Y
V
Y
T
H
R
L
F
H
R
Site 19
T171
A
Y
S
G
Y
V
Y
T
H
R
L
F
H
R
G
Site 20
Y183
H
R
G
E
D
E
P
Y
S
E
P
Y
A
D
Y
Site 21
S184
R
G
E
D
E
P
Y
S
E
P
Y
A
D
Y
G
Site 22
Y187
D
E
P
Y
S
E
P
Y
A
D
Y
G
G
L
Q
Site 23
Y190
Y
S
E
P
Y
A
D
Y
G
G
L
Q
E
H
V
Site 24
Y198
G
G
L
Q
E
H
V
Y
E
E
I
G
D
A
P
Site 25
Y216
A
R
D
G
L
R
L
Y
E
Q
E
R
D
E
A
Site 26
Y226
E
R
D
E
A
A
A
Y
R
Q
E
A
L
G
A
Site 27
Y238
L
G
A
R
L
H
H
Y
D
E
R
S
D
G
E
Site 28
S242
L
H
H
Y
D
E
R
S
D
G
E
S
D
S
P
Site 29
S246
D
E
R
S
D
G
E
S
D
S
P
E
K
E
A
Site 30
S248
R
S
D
G
E
S
D
S
P
E
K
E
A
E
F
Site 31
Y258
K
E
A
E
F
A
P
Y
P
R
M
D
S
Y
E
Site 32
S263
A
P
Y
P
R
M
D
S
Y
E
Q
E
E
D
I
Site 33
Y264
P
Y
P
R
M
D
S
Y
E
Q
E
E
D
I
D
Site 34
S280
I
V
A
E
V
K
Q
S
M
S
S
Q
S
L
D
Site 35
S282
A
E
V
K
Q
S
M
S
S
Q
S
L
D
K
A
Site 36
S285
K
Q
S
M
S
S
Q
S
L
D
K
A
A
E
D
Site 37
T305
Q
D
L
E
R
P
P
T
P
A
G
G
R
P
D
Site 38
S313
P
A
G
G
R
P
D
S
P
G
L
Q
A
P
A
Site 39
S339
G
E
A
G
Q
R
Y
S
K
E
K
R
D
A
I
Site 40
S347
K
E
K
R
D
A
I
S
L
A
I
K
D
I
K
Site 41
T362
E
A
I
E
E
V
K
T
R
T
I
R
S
P
Y
Site 42
S367
V
K
T
R
T
I
R
S
P
Y
T
P
D
E
P
Site 43
Y369
T
R
T
I
R
S
P
Y
T
P
D
E
P
K
E
Site 44
T370
R
T
I
R
S
P
Y
T
P
D
E
P
K
E
P
Site 45
T388
M
R
Q
D
I
S
P
T
R
D
C
D
D
Q
R
Site 46
S401
Q
R
P
M
D
G
D
S
P
S
P
G
S
S
S
Site 47
S403
P
M
D
G
D
S
P
S
P
G
S
S
S
P
L
Site 48
S406
G
D
S
P
S
P
G
S
S
S
P
L
G
A
E
Site 49
S407
D
S
P
S
P
G
S
S
S
P
L
G
A
E
S
Site 50
S408
S
P
S
P
G
S
S
S
P
L
G
A
E
S
S
Site 51
S414
S
S
P
L
G
A
E
S
S
S
T
S
L
H
P
Site 52
S415
S
P
L
G
A
E
S
S
S
T
S
L
H
P
S
Site 53
S416
P
L
G
A
E
S
S
S
T
S
L
H
P
S
D
Site 54
T417
L
G
A
E
S
S
S
T
S
L
H
P
S
D
P
Site 55
S418
G
A
E
S
S
S
T
S
L
H
P
S
D
P
V
Site 56
S422
S
S
T
S
L
H
P
S
D
P
V
E
A
S
T
Site 57
S428
P
S
D
P
V
E
A
S
T
N
K
E
S
R
K
Site 58
T429
S
D
P
V
E
A
S
T
N
K
E
S
R
K
S
Site 59
S436
T
N
K
E
S
R
K
S
L
A
S
F
P
T
Y
Site 60
S439
E
S
R
K
S
L
A
S
F
P
T
Y
V
E
V
Site 61
T442
K
S
L
A
S
F
P
T
Y
V
E
V
P
G
P
Site 62
S473
L
G
S
T
Q
L
L
S
D
K
T
P
S
K
N
Site 63
T476
T
Q
L
L
S
D
K
T
P
S
K
N
V
R
M
Site 64
T515
E
G
E
S
Q
P
M
T
E
V
D
L
F
I
S
Site 65
S546
D
H
P
L
R
T
I
S
Y
I
A
D
I
G
N
Site 66
S566
A
R
R
R
M
P
R
S
N
S
Q
E
N
V
E
Site 67
S568
R
R
M
P
R
S
N
S
Q
E
N
V
E
A
S
Site 68
S578
N
V
E
A
S
H
P
S
Q
D
G
K
R
Q
Y
Site 69
Y585
S
Q
D
G
K
R
Q
Y
K
M
I
C
H
V
F
Site 70
S627
G
I
N
P
E
D
L
S
Q
K
E
Y
S
D
L
Site 71
Y631
E
D
L
S
Q
K
E
Y
S
D
L
L
N
T
Q
Site 72
Y641
L
L
N
T
Q
D
M
Y
N
D
D
L
I
H
F
Site 73
S649
N
D
D
L
I
H
F
S
K
S
E
N
C
K
D
Site 74
S697
H
G
G
P
A
E
K
S
G
K
L
N
I
G
D
Site 75
Y757
I
R
R
P
D
L
R
Y
Q
L
G
F
S
V
Q
Site 76
T799
N
G
Q
S
V
V
A
T
P
H
E
K
I
V
H
Site 77
T829
A
A
M
Y
R
L
L
T
A
Q
E
Q
P
V
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation