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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLK2
Full Name:
Mitogen-activated protein kinase kinase kinase 10
Alias:
EC 2.7.11.25; Kinase MLK2; M3K10; MAP3K10; MEKK10; Mitogen-activated protein kinase kinase kinase 10; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MST; Protein kinase MST
Type:
EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor);
TKL
group; MLK family; MLK subfamily
Mass (Da):
103623
Number AA:
954
UniProt ID:
Q02779
International Prot ID:
IPI00295401
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004706
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0007257
GO:0006917
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Mixed-lineage protein-serine kinase 2 / Mitogen-activated protein kinase kinase kinase 10 (S926-S943, human) peptide - Powder PE-01BDZ85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDZ85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
V
A
K
E
W
G
T
T
P
A
G
P
V
W
T
Site 2
Y27
V
W
T
A
V
F
D
Y
E
A
A
G
D
E
E
Site 3
T36
A
A
G
D
E
E
L
T
L
R
R
G
D
R
V
Site 4
S47
G
D
R
V
Q
V
L
S
Q
D
C
A
V
S
G
Site 5
T60
S
G
D
E
G
W
W
T
G
Q
L
P
S
G
R
Site 6
Y113
V
G
G
F
G
K
V
Y
R
A
L
W
R
G
E
Site 7
S183
Y
A
R
G
G
A
L
S
R
V
L
A
G
R
R
Site 8
T242
E
N
H
N
L
A
D
T
V
L
K
I
T
D
F
Site 9
T258
L
A
R
E
W
H
K
T
T
K
M
S
A
A
G
Site 10
S262
W
H
K
T
T
K
M
S
A
A
G
T
Y
A
W
Site 11
T266
T
K
M
S
A
A
G
T
Y
A
W
M
A
P
E
Site 12
S278
A
P
E
V
I
R
L
S
L
F
S
K
S
S
D
Site 13
S283
R
L
S
L
F
S
K
S
S
D
V
W
S
F
G
Site 14
S288
S
K
S
S
D
V
W
S
F
G
V
L
L
W
E
Site 15
S352
H
G
R
P
D
F
G
S
I
L
K
R
L
E
V
Site 16
S372
L
F
Q
M
P
L
E
S
F
H
S
L
Q
E
D
Site 17
S375
M
P
L
E
S
F
H
S
L
Q
E
D
W
K
L
Site 18
T393
H
M
F
D
D
L
R
T
K
E
K
E
L
R
S
Site 19
S400
T
K
E
K
E
L
R
S
R
E
E
E
L
L
R
Site 20
S446
H
L
L
M
C
Q
L
S
Q
E
K
P
R
V
R
Site 21
S472
L
K
L
R
E
G
G
S
H
I
S
L
P
S
G
Site 22
S475
R
E
G
G
S
H
I
S
L
P
S
G
F
E
H
Site 23
T485
S
G
F
E
H
K
I
T
V
Q
A
S
P
T
L
Site 24
S489
H
K
I
T
V
Q
A
S
P
T
L
D
K
R
K
Site 25
T491
I
T
V
Q
A
S
P
T
L
D
K
R
K
G
S
Site 26
S498
T
L
D
K
R
K
G
S
D
G
A
S
P
P
A
Site 27
S502
R
K
G
S
D
G
A
S
P
P
A
S
P
S
I
Site 28
S506
D
G
A
S
P
P
A
S
P
S
I
I
P
R
L
Site 29
S508
A
S
P
P
A
S
P
S
I
I
P
R
L
R
A
Site 30
T519
R
L
R
A
I
R
L
T
P
V
D
C
G
G
S
Site 31
S526
T
P
V
D
C
G
G
S
S
S
G
S
S
S
G
Site 32
S527
P
V
D
C
G
G
S
S
S
G
S
S
S
G
G
Site 33
S528
V
D
C
G
G
S
S
S
G
S
S
S
G
G
S
Site 34
S530
C
G
G
S
S
S
G
S
S
S
G
G
S
G
T
Site 35
S531
G
G
S
S
S
G
S
S
S
G
G
S
G
T
W
Site 36
S532
G
S
S
S
G
S
S
S
G
G
S
G
T
W
S
Site 37
S535
S
G
S
S
S
G
G
S
G
T
W
S
R
G
G
Site 38
T537
S
S
S
G
G
S
G
T
W
S
R
G
G
P
P
Site 39
S539
S
G
G
S
G
T
W
S
R
G
G
P
P
K
K
Site 40
T558
G
G
K
K
K
G
R
T
W
G
P
S
S
T
L
Site 41
S562
K
G
R
T
W
G
P
S
S
T
L
Q
K
E
R
Site 42
S563
G
R
T
W
G
P
S
S
T
L
Q
K
E
R
V
Site 43
T564
R
T
W
G
P
S
S
T
L
Q
K
E
R
V
G
Site 44
S583
L
K
G
L
G
E
G
S
K
Q
W
S
S
S
A
Site 45
S587
G
E
G
S
K
Q
W
S
S
S
A
P
N
L
G
Site 46
S588
E
G
S
K
Q
W
S
S
S
A
P
N
L
G
K
Site 47
S589
G
S
K
Q
W
S
S
S
A
P
N
L
G
K
S
Site 48
S596
S
A
P
N
L
G
K
S
P
K
H
T
P
I
A
Site 49
T600
L
G
K
S
P
K
H
T
P
I
A
P
G
F
A
Site 50
S608
P
I
A
P
G
F
A
S
L
N
E
M
E
E
F
Site 51
S623
A
E
A
E
D
G
G
S
S
V
P
P
S
P
Y
Site 52
S624
E
A
E
D
G
G
S
S
V
P
P
S
P
Y
S
Site 53
S628
G
G
S
S
V
P
P
S
P
Y
S
T
P
S
Y
Site 54
Y630
S
S
V
P
P
S
P
Y
S
T
P
S
Y
L
S
Site 55
S631
S
V
P
P
S
P
Y
S
T
P
S
Y
L
S
V
Site 56
T632
V
P
P
S
P
Y
S
T
P
S
Y
L
S
V
P
Site 57
S634
P
S
P
Y
S
T
P
S
Y
L
S
V
P
L
P
Site 58
Y635
S
P
Y
S
T
P
S
Y
L
S
V
P
L
P
A
Site 59
S637
Y
S
T
P
S
Y
L
S
V
P
L
P
A
E
P
Site 60
S645
V
P
L
P
A
E
P
S
P
G
A
R
A
P
W
Site 61
T655
A
R
A
P
W
E
P
T
P
S
A
P
P
A
R
Site 62
S657
A
P
W
E
P
T
P
S
A
P
P
A
R
W
G
Site 63
S722
G
R
F
P
R
G
L
S
P
P
A
R
P
H
G
Site 64
S753
L
V
S
L
S
S
V
S
D
C
N
S
T
R
S
Site 65
S757
S
S
V
S
D
C
N
S
T
R
S
L
L
R
S
Site 66
S760
S
D
C
N
S
T
R
S
L
L
R
S
D
S
D
Site 67
S764
S
T
R
S
L
L
R
S
D
S
D
E
A
A
P
Site 68
S766
R
S
L
L
R
S
D
S
D
E
A
A
P
A
A
Site 69
S775
E
A
A
P
A
A
P
S
P
P
P
S
P
P
A
Site 70
S779
A
A
P
S
P
P
P
S
P
P
A
P
T
P
T
Site 71
T784
P
P
S
P
P
A
P
T
P
T
P
S
P
S
T
Site 72
T786
S
P
P
A
P
T
P
T
P
S
P
S
T
N
P
Site 73
S788
P
A
P
T
P
T
P
S
P
S
T
N
P
L
V
Site 74
S790
P
T
P
T
P
S
P
S
T
N
P
L
V
D
L
Site 75
S801
L
V
D
L
E
L
E
S
F
K
K
D
P
R
Q
Site 76
S809
F
K
K
D
P
R
Q
S
L
T
P
T
H
V
T
Site 77
T811
K
D
P
R
Q
S
L
T
P
T
H
V
T
A
A
Site 78
T813
P
R
Q
S
L
T
P
T
H
V
T
A
A
C
A
Site 79
T828
V
S
R
G
H
R
R
T
P
S
D
G
A
L
G
Site 80
S830
R
G
H
R
R
T
P
S
D
G
A
L
G
Q
R
Site 81
T879
P
E
F
P
G
R
P
T
T
L
T
F
A
P
R
Site 82
T880
E
F
P
G
R
P
T
T
L
T
F
A
P
R
P
Site 83
T882
P
G
R
P
T
T
L
T
F
A
P
R
P
R
P
Site 84
S892
P
R
P
R
P
A
A
S
R
P
R
L
D
P
W
Site 85
T909
V
S
F
G
R
T
L
T
I
S
P
P
S
R
P
Site 86
S911
F
G
R
T
L
T
I
S
P
P
S
R
P
D
T
Site 87
S914
T
L
T
I
S
P
P
S
R
P
D
T
P
E
S
Site 88
T918
S
P
P
S
R
P
D
T
P
E
S
P
G
P
P
Site 89
S921
S
R
P
D
T
P
E
S
P
G
P
P
S
V
Q
Site 90
S926
P
E
S
P
G
P
P
S
V
Q
P
T
L
L
D
Site 91
T930
G
P
P
S
V
Q
P
T
L
L
D
M
D
M
E
Site 92
S943
M
E
G
Q
N
Q
D
S
T
V
P
L
C
G
A
Site 93
T944
E
G
Q
N
Q
D
S
T
V
P
L
C
G
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation