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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUCY2D
Full Name:
Retinal guanylyl cyclase 1
Alias:
Guanylate cyclase 2D, retinal;Rod outer segment membrane guanylate cyclase
Type:
Mass (Da):
120059
Number AA:
1103
UniProt ID:
Q02846
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
G
P
A
W
W
A
P
S
L
P
R
L
P
R
A
Site 2
S214
A
R
G
L
P
V
A
S
V
T
S
M
E
P
L
Site 3
S527
S
R
K
V
A
Q
G
S
R
S
S
L
G
A
R
Site 4
S529
K
V
A
Q
G
S
R
S
S
L
G
A
R
S
M
Site 5
S530
V
A
Q
G
S
R
S
S
L
G
A
R
S
M
S
Site 6
S535
R
S
S
L
G
A
R
S
M
S
D
I
R
S
G
Site 7
S537
S
L
G
A
R
S
M
S
D
I
R
S
G
P
S
Site 8
S541
R
S
M
S
D
I
R
S
G
P
S
Q
H
L
D
Site 9
S544
S
D
I
R
S
G
P
S
Q
H
L
D
S
P
N
Site 10
S549
G
P
S
Q
H
L
D
S
P
N
I
G
V
Y
E
Site 11
Y555
D
S
P
N
I
G
V
Y
E
G
D
R
V
W
L
Site 12
T579
A
I
R
P
A
T
K
T
A
F
S
K
L
Q
E
Site 13
S619
E
G
N
L
A
V
V
S
E
H
C
T
R
G
S
Site 14
S626
S
E
H
C
T
R
G
S
L
Q
D
L
L
A
Q
Site 15
Y656
D
L
I
K
G
I
R
Y
L
H
H
R
G
V
A
Site 16
S669
V
A
H
G
R
L
K
S
R
N
C
I
V
D
G
Site 17
T724
P
A
L
E
R
R
G
T
L
A
G
D
V
F
S
Site 18
T752
P
Y
A
M
L
E
L
T
P
E
E
V
V
Q
R
Site 19
S762
E
V
V
Q
R
V
R
S
P
P
P
L
C
R
P
Site 20
S797
E
Q
P
E
L
R
P
S
M
D
H
T
F
D
L
Site 21
T801
L
R
P
S
M
D
H
T
F
D
L
F
K
N
I
Site 22
T814
N
I
N
K
G
R
K
T
N
I
I
D
S
M
L
Site 23
S819
R
K
T
N
I
I
D
S
M
L
R
M
L
E
Q
Site 24
Y827
M
L
R
M
L
E
Q
Y
S
S
N
L
E
D
L
Site 25
S829
R
M
L
E
Q
Y
S
S
N
L
E
D
L
I
R
Site 26
T839
E
D
L
I
R
E
R
T
E
E
L
E
L
E
K
Site 27
T849
L
E
L
E
K
Q
K
T
D
R
L
L
T
Q
M
Site 28
T854
Q
K
T
D
R
L
L
T
Q
M
L
P
P
S
V
Site 29
T867
S
V
A
E
A
L
K
T
G
T
P
V
E
P
E
Site 30
T869
A
E
A
L
K
T
G
T
P
V
E
P
E
Y
F
Site 31
Y875
G
T
P
V
E
P
E
Y
F
E
Q
V
T
L
Y
Site 32
Y922
I
I
G
S
H
D
V
Y
K
V
E
T
I
G
D
Site 33
S1007
G
D
T
V
N
T
A
S
R
M
E
S
T
G
L
Site 34
S1011
N
T
A
S
R
M
E
S
T
G
L
P
Y
R
I
Site 35
S1033
G
I
L
R
A
L
D
S
G
Y
Q
V
E
L
R
Site 36
Y1035
L
R
A
L
D
S
G
Y
Q
V
E
L
R
G
R
Site 37
T1043
Q
V
E
L
R
G
R
T
E
L
K
G
K
G
A
Site 38
T1053
K
G
K
G
A
E
D
T
F
W
L
V
G
R
R
Site 39
S1076
P
P
D
L
Q
P
G
S
S
N
H
G
I
S
L
Site 40
S1077
P
D
L
Q
P
G
S
S
N
H
G
I
S
L
Q
Site 41
S1082
G
S
S
N
H
G
I
S
L
Q
E
I
P
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation