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Updated November 2019
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Protein Info
Short Name:
EVI1
Full Name:
MDS1 and EVI1 complex locus protein EVI1
Alias:
AML1-EVI-1; Ecotropic viral integration site 1; EVI-1; MDS1; MDS1 and EVI1 complex locus; MDS1-EVI1; MGC163392; PRDM3
Type:
Mass (Da):
118276
Number AA:
1051
UniProt ID:
Q03112
International Prot ID:
IPI00446866
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
S
E
D
Y
P
H
E
T
M
A
P
D
I
H
E
Site 2
Y21
D
I
H
E
E
R
Q
Y
R
C
E
D
C
D
Q
Site 3
S32
D
C
D
Q
L
F
E
S
K
A
E
L
A
D
H
Site 4
S45
D
H
Q
K
F
P
C
S
T
P
H
S
A
F
S
Site 5
T46
H
Q
K
F
P
C
S
T
P
H
S
A
F
S
M
Site 6
S49
F
P
C
S
T
P
H
S
A
F
S
M
V
E
E
Site 7
S52
S
T
P
H
S
A
F
S
M
V
E
E
D
F
Q
Site 8
S64
D
F
Q
Q
K
L
E
S
E
N
D
L
Q
E
I
Site 9
S89
Q
V
F
P
D
L
Q
S
L
E
K
H
M
L
S
Site 10
S96
S
L
E
K
H
M
L
S
H
T
E
E
R
E
Y
Site 11
T98
E
K
H
M
L
S
H
T
E
E
R
E
Y
K
C
Site 12
Y103
S
H
T
E
E
R
E
Y
K
C
D
Q
C
P
K
Site 13
Y131
S
H
D
S
G
K
H
Y
E
C
E
N
C
A
K
Site 14
S144
A
K
V
F
T
D
P
S
N
L
Q
R
H
I
R
Site 15
S152
N
L
Q
R
H
I
R
S
Q
H
V
G
A
R
A
Site 16
S173
G
K
T
F
A
T
S
S
G
L
K
Q
H
K
H
Site 17
T215
R
M
H
A
D
C
R
T
Q
I
K
C
K
D
C
Site 18
S227
K
D
C
G
Q
M
F
S
T
T
S
S
L
N
K
Site 19
T228
D
C
G
Q
M
F
S
T
T
S
S
L
N
K
H
Site 20
T229
C
G
Q
M
F
S
T
T
S
S
L
N
K
H
R
Site 21
S231
Q
M
F
S
T
T
S
S
L
N
K
H
R
R
F
Site 22
T260
Q
G
I
S
L
P
G
T
P
A
M
D
K
T
S
Site 23
T266
G
T
P
A
M
D
K
T
S
M
V
N
M
S
H
Site 24
Y281
A
N
P
G
L
A
D
Y
F
G
A
N
R
H
P
Site 25
T292
N
R
H
P
A
G
L
T
F
P
T
A
P
G
F
Site 26
S309
S
F
P
G
L
F
P
S
G
L
Y
H
R
P
P
Site 27
S321
R
P
P
L
I
P
A
S
S
P
V
K
G
L
S
Site 28
S328
S
S
P
V
K
G
L
S
S
T
E
Q
T
N
K
Site 29
T333
G
L
S
S
T
E
Q
T
N
K
S
Q
S
P
L
Site 30
S336
S
T
E
Q
T
N
K
S
Q
S
P
L
M
T
H
Site 31
S338
E
Q
T
N
K
S
Q
S
P
L
M
T
H
P
Q
Site 32
T342
K
S
Q
S
P
L
M
T
H
P
Q
I
L
P
A
Site 33
S358
Q
D
I
L
K
A
L
S
K
H
P
S
V
G
D
Site 34
S362
K
A
L
S
K
H
P
S
V
G
D
N
K
P
V
Site 35
S376
V
E
L
Q
P
E
R
S
S
E
E
R
P
F
E
Site 36
S377
E
L
Q
P
E
R
S
S
E
E
R
P
F
E
K
Site 37
S386
E
R
P
F
E
K
I
S
D
Q
S
E
S
S
D
Site 38
S389
F
E
K
I
S
D
Q
S
E
S
S
D
L
D
D
Site 39
S398
S
S
D
L
D
D
V
S
T
P
S
G
S
D
L
Site 40
T399
S
D
L
D
D
V
S
T
P
S
G
S
D
L
E
Site 41
S401
L
D
D
V
S
T
P
S
G
S
D
L
E
T
T
Site 42
S403
D
V
S
T
P
S
G
S
D
L
E
T
T
S
G
Site 43
T407
P
S
G
S
D
L
E
T
T
S
G
S
D
L
E
Site 44
S409
G
S
D
L
E
T
T
S
G
S
D
L
E
S
D
Site 45
S411
D
L
E
T
T
S
G
S
D
L
E
S
D
I
E
Site 46
S415
T
S
G
S
D
L
E
S
D
I
E
S
D
K
E
Site 47
S419
D
L
E
S
D
I
E
S
D
K
E
K
F
K
E
Site 48
S436
K
M
F
K
D
K
V
S
P
L
Q
N
L
A
S
Site 49
S443
S
P
L
Q
N
L
A
S
I
N
N
K
K
E
Y
Site 50
Y450
S
I
N
N
K
K
E
Y
S
N
H
S
I
F
S
Site 51
S451
I
N
N
K
K
E
Y
S
N
H
S
I
F
S
P
Site 52
S454
K
K
E
Y
S
N
H
S
I
F
S
P
S
L
E
Site 53
S457
Y
S
N
H
S
I
F
S
P
S
L
E
E
Q
T
Site 54
Y520
P
A
F
S
Q
S
M
Y
P
F
P
D
R
D
L
Site 55
S529
F
P
D
R
D
L
R
S
L
P
L
K
M
E
P
Site 56
S538
P
L
K
M
E
P
Q
S
P
G
E
V
K
K
L
Site 57
S550
K
K
L
Q
K
G
S
S
E
S
P
F
D
L
T
Site 58
S552
L
Q
K
G
S
S
E
S
P
F
D
L
T
T
K
Site 59
T557
S
E
S
P
F
D
L
T
T
K
R
K
D
E
K
Site 60
T558
E
S
P
F
D
L
T
T
K
R
K
D
E
K
P
Site 61
T567
R
K
D
E
K
P
L
T
P
V
P
S
K
P
P
Site 62
S571
K
P
L
T
P
V
P
S
K
P
P
V
T
P
A
Site 63
T576
V
P
S
K
P
P
V
T
P
A
T
S
Q
D
Q
Site 64
T579
K
P
P
V
T
P
A
T
S
Q
D
Q
P
L
D
Site 65
S580
P
P
V
T
P
A
T
S
Q
D
Q
P
L
D
L
Site 66
S588
Q
D
Q
P
L
D
L
S
M
G
S
R
S
R
A
Site 67
S591
P
L
D
L
S
M
G
S
R
S
R
A
S
G
T
Site 68
S593
D
L
S
M
G
S
R
S
R
A
S
G
T
K
L
Site 69
S596
M
G
S
R
S
R
A
S
G
T
K
L
T
E
P
Site 70
T601
R
A
S
G
T
K
L
T
E
P
R
K
N
H
V
Site 71
S615
V
F
G
G
K
K
G
S
N
V
E
S
R
P
A
Site 72
S619
K
K
G
S
N
V
E
S
R
P
A
S
D
G
S
Site 73
S623
N
V
E
S
R
P
A
S
D
G
S
L
Q
H
A
Site 74
S626
S
R
P
A
S
D
G
S
L
Q
H
A
R
P
T
Site 75
T633
S
L
Q
H
A
R
P
T
P
F
F
M
D
P
I
Site 76
Y641
P
F
F
M
D
P
I
Y
R
V
E
K
R
K
L
Site 77
T649
R
V
E
K
R
K
L
T
D
P
L
E
A
L
K
Site 78
Y659
L
E
A
L
K
E
K
Y
L
R
P
S
P
G
F
Site 79
S663
K
E
K
Y
L
R
P
S
P
G
F
L
F
H
P
Site 80
T679
F
Q
L
P
D
Q
R
T
W
M
S
A
I
E
N
Site 81
S693
N
M
A
E
K
L
E
S
F
S
A
L
K
P
E
Site 82
S702
S
A
L
K
P
E
A
S
E
L
L
Q
S
V
P
Site 83
S710
E
L
L
Q
S
V
P
S
M
F
N
F
R
A
P
Site 84
Y733
L
R
K
G
K
E
R
Y
T
C
R
Y
C
G
K
Site 85
Y737
K
E
R
Y
T
C
R
Y
C
G
K
I
F
P
R
Site 86
S745
C
G
K
I
F
P
R
S
A
N
L
T
R
H
L
Site 87
T749
F
P
R
S
A
N
L
T
R
H
L
R
T
H
T
Site 88
T756
T
R
H
L
R
T
H
T
G
E
Q
P
Y
R
C
Site 89
Y765
E
Q
P
Y
R
C
K
Y
C
D
R
S
F
S
I
Site 90
S769
R
C
K
Y
C
D
R
S
F
S
I
S
S
N
L
Site 91
S771
K
Y
C
D
R
S
F
S
I
S
S
N
L
Q
R
Site 92
S773
C
D
R
S
F
S
I
S
S
N
L
Q
R
H
V
Site 93
S818
K
H
E
N
G
N
M
S
G
T
A
T
S
S
P
Site 94
T820
E
N
G
N
M
S
G
T
A
T
S
S
P
H
S
Site 95
T822
G
N
M
S
G
T
A
T
S
S
P
H
S
E
L
Site 96
S823
N
M
S
G
T
A
T
S
S
P
H
S
E
L
E
Site 97
S824
M
S
G
T
A
T
S
S
P
H
S
E
L
E
S
Site 98
S827
T
A
T
S
S
P
H
S
E
L
E
S
T
G
A
Site 99
S831
S
P
H
S
E
L
E
S
T
G
A
I
L
D
D
Site 100
T832
P
H
S
E
L
E
S
T
G
A
I
L
D
D
K
Site 101
Y843
L
D
D
K
E
D
A
Y
F
T
E
I
R
N
F
Site 102
S854
I
R
N
F
I
G
N
S
N
H
G
S
Q
S
P
Site 103
S858
I
G
N
S
N
H
G
S
Q
S
P
R
N
V
E
Site 104
S860
N
S
N
H
G
S
Q
S
P
R
N
V
E
E
R
Site 105
S882
D
E
K
A
L
V
T
S
Q
N
S
D
L
L
D
Site 106
T909
E
D
E
D
N
D
I
T
G
K
T
G
K
E
P
Site 107
S919
T
G
K
E
P
V
T
S
N
L
H
E
G
N
P
Site 108
Y930
E
G
N
P
E
D
D
Y
E
E
T
S
A
L
E
Site 109
S934
E
D
D
Y
E
E
T
S
A
L
E
M
S
C
K
Site 110
S939
E
T
S
A
L
E
M
S
C
K
T
S
P
V
R
Site 111
S943
L
E
M
S
C
K
T
S
P
V
R
Y
K
E
E
Site 112
Y952
V
R
Y
K
E
E
E
Y
K
S
G
L
S
A
L
Site 113
S954
Y
K
E
E
E
Y
K
S
G
L
S
A
L
D
H
Site 114
T966
L
D
H
I
R
H
F
T
D
S
L
K
M
R
K
Site 115
Y979
R
K
M
E
D
N
Q
Y
S
E
A
E
L
S
S
Site 116
S980
K
M
E
D
N
Q
Y
S
E
A
E
L
S
S
F
Site 117
S985
Q
Y
S
E
A
E
L
S
S
F
S
T
S
H
V
Site 118
S986
Y
S
E
A
E
L
S
S
F
S
T
S
H
V
P
Site 119
S988
E
A
E
L
S
S
F
S
T
S
H
V
P
E
E
Site 120
T989
A
E
L
S
S
F
S
T
S
H
V
P
E
E
L
Site 121
S990
E
L
S
S
F
S
T
S
H
V
P
E
E
L
K
Site 122
S1004
K
Q
P
L
H
R
K
S
K
S
Q
A
Y
A
M
Site 123
S1006
P
L
H
R
K
S
K
S
Q
A
Y
A
M
M
L
Site 124
S1014
Q
A
Y
A
M
M
L
S
L
S
D
K
E
S
L
Site 125
S1016
Y
A
M
M
L
S
L
S
D
K
E
S
L
H
S
Site 126
S1020
L
S
L
S
D
K
E
S
L
H
S
T
S
H
S
Site 127
S1023
S
D
K
E
S
L
H
S
T
S
H
S
S
S
N
Site 128
T1024
D
K
E
S
L
H
S
T
S
H
S
S
S
N
V
Site 129
S1025
K
E
S
L
H
S
T
S
H
S
S
S
N
V
W
Site 130
S1027
S
L
H
S
T
S
H
S
S
S
N
V
W
H
S
Site 131
S1028
L
H
S
T
S
H
S
S
S
N
V
W
H
S
M
Site 132
S1029
H
S
T
S
H
S
S
S
N
V
W
H
S
M
A
Site 133
S1034
S
S
S
N
V
W
H
S
M
A
R
A
A
A
E
Site 134
S1043
A
R
A
A
A
E
S
S
A
I
Q
S
I
S
H
Site 135
S1047
A
E
S
S
A
I
Q
S
I
S
H
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation