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Updated November 2019
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Protein Info
Short Name:
ERCC6
Full Name:
DNA excision repair protein ERCC-6
Alias:
ATP-dependent helicase ERCC6; CKN2; Cockayne syndrome B protein; Cockayne syndrome group B protein; Cockayne syndrome protein CSB; COFS; CSB; DNA excision repair protein ERCC-6: ATP-dependent helicase ERCC6: Cockayne syndrome protein CSB: Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant; Excision repair cross-complementing rodent repair deficiency, complementation group 6; RAD26
Type:
DNA repair; EC 3.6.1.-; Transcription regulation; Helicase
Mass (Da):
168416
Number AA:
1493
UniProt ID:
Q03468
International Prot ID:
IPI00414779
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005625
GO:0008023
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0008094
PhosphoSite+
KinaseNET
Biological Process:
GO:0006284
GO:0032786
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
N
E
G
I
P
H
S
S
Q
T
Q
E
Q
D
Site 2
S10
N
E
G
I
P
H
S
S
Q
T
Q
E
Q
D
C
Site 3
S20
Q
E
Q
D
C
L
Q
S
Q
P
V
S
N
N
E
Site 4
S24
C
L
Q
S
Q
P
V
S
N
N
E
E
M
A
I
Site 5
Y44
G
D
G
E
V
E
E
Y
L
S
F
R
S
V
G
Site 6
S46
G
E
V
E
E
Y
L
S
F
R
S
V
G
D
G
Site 7
S49
E
E
Y
L
S
F
R
S
V
G
D
G
L
S
T
Site 8
Y100
Q
G
L
G
V
D
V
Y
D
Q
D
V
L
E
Q
Site 9
S121
D
N
A
I
H
E
A
S
R
A
S
Q
L
V
D
Site 10
S124
I
H
E
A
S
R
A
S
Q
L
V
D
V
E
K
Site 11
S135
D
V
E
K
E
Y
R
S
V
L
D
D
L
T
S
Site 12
T141
R
S
V
L
D
D
L
T
S
C
T
T
S
L
R
Site 13
S142
S
V
L
D
D
L
T
S
C
T
T
S
L
R
Q
Site 14
S146
D
L
T
S
C
T
T
S
L
R
Q
I
N
K
I
Site 15
S158
N
K
I
I
E
Q
L
S
P
Q
A
A
T
S
R
Site 16
S173
D
I
N
R
K
L
D
S
V
K
R
Q
K
Y
N
Site 17
Y179
D
S
V
K
R
Q
K
Y
N
K
E
Q
Q
L
K
Site 18
S212
K
I
E
L
D
H
A
S
L
E
E
D
A
E
P
Site 19
S222
E
D
A
E
P
G
P
S
S
L
G
S
M
L
M
Site 20
S223
D
A
E
P
G
P
S
S
L
G
S
M
L
M
P
Site 21
S226
P
G
P
S
S
L
G
S
M
L
M
P
V
Q
E
Site 22
T242
A
W
E
E
L
I
R
T
G
Q
M
T
P
F
G
Site 23
T246
L
I
R
T
G
Q
M
T
P
F
G
T
Q
I
P
Site 24
T250
G
Q
M
T
P
F
G
T
Q
I
P
Q
K
Q
E
Site 25
Y274
E
A
S
G
F
E
K
Y
L
A
D
Q
A
K
L
Site 26
S282
L
A
D
Q
A
K
L
S
F
E
R
K
K
Q
G
Site 27
T303
R
K
A
P
A
P
V
T
P
P
A
P
V
Q
N
Site 28
S322
N
K
K
A
R
V
L
S
K
K
E
E
R
L
K
Site 29
S357
K
A
R
R
P
W
E
S
D
M
R
P
E
A
E
Site 30
S367
R
P
E
A
E
G
D
S
E
G
E
E
S
E
Y
Site 31
S372
G
D
S
E
G
E
E
S
E
Y
F
P
T
E
E
Site 32
Y374
S
E
G
E
E
S
E
Y
F
P
T
E
E
E
E
Site 33
T377
E
E
S
E
Y
F
P
T
E
E
E
E
E
E
E
Site 34
S396
E
G
A
E
A
D
L
S
G
D
G
T
D
Y
E
Site 35
T400
A
D
L
S
G
D
G
T
D
Y
E
L
K
P
L
Site 36
Y402
L
S
G
D
G
T
D
Y
E
L
K
P
L
P
K
Site 37
S429
I
D
D
D
F
F
P
S
S
G
E
E
A
E
A
Site 38
S430
D
D
D
F
F
P
S
S
G
E
E
A
E
A
A
Site 39
S438
G
E
E
A
E
A
A
S
V
G
E
G
G
G
G
Site 40
Y452
G
G
R
K
V
G
R
Y
R
D
D
G
D
E
D
Site 41
Y460
R
D
D
G
D
E
D
Y
Y
K
Q
R
L
R
R
Site 42
Y461
D
D
G
D
E
D
Y
Y
K
Q
R
L
R
R
W
Site 43
S486
R
L
K
L
E
D
D
S
E
E
S
D
A
E
F
Site 44
S489
L
E
D
D
S
E
E
S
D
A
E
F
D
E
G
Site 45
Y510
L
F
K
K
L
F
K
Y
Q
Q
T
G
V
R
W
Site 46
S552
F
L
A
G
L
S
Y
S
K
I
R
T
R
G
S
Site 47
T556
L
S
Y
S
K
I
R
T
R
G
S
N
Y
R
F
Site 48
S559
S
K
I
R
T
R
G
S
N
Y
R
F
E
G
L
Site 49
S602
A
I
L
H
E
T
G
S
Y
T
H
K
K
E
K
Site 50
Y603
I
L
H
E
T
G
S
Y
T
H
K
K
E
K
L
Site 51
Y638
M
Q
D
D
I
S
R
Y
D
W
H
Y
V
I
L
Site 52
Y642
I
S
R
Y
D
W
H
Y
V
I
L
D
E
G
H
Site 53
T659
R
N
P
N
A
A
V
T
L
A
C
K
Q
F
R
Site 54
T667
L
A
C
K
Q
F
R
T
P
H
R
I
I
L
S
Site 55
S674
T
P
H
R
I
I
L
S
G
S
P
M
Q
N
N
Site 56
S676
H
R
I
I
L
S
G
S
P
M
Q
N
N
L
R
Site 57
T712
E
Q
F
S
V
P
I
T
M
G
G
Y
S
N
A
Site 58
Y716
V
P
I
T
M
G
G
Y
S
N
A
S
P
V
Q
Site 59
S720
M
G
G
Y
S
N
A
S
P
V
Q
V
K
T
A
Site 60
Y741
L
R
D
T
I
N
P
Y
L
L
R
R
M
K
S
Site 61
S748
Y
L
L
R
R
M
K
S
D
V
K
M
S
L
S
Site 62
S753
M
K
S
D
V
K
M
S
L
S
L
P
D
K
N
Site 63
S755
S
D
V
K
M
S
L
S
L
P
D
K
N
E
Q
Site 64
T769
Q
V
L
F
C
R
L
T
D
E
Q
H
K
V
Y
Site 65
Y776
T
D
E
Q
H
K
V
Y
Q
N
F
V
D
S
K
Site 66
Y786
F
V
D
S
K
E
V
Y
R
I
L
N
G
E
M
Site 67
S813
C
N
H
P
D
L
F
S
G
G
P
K
N
L
K
Site 68
Y834
L
E
E
D
Q
F
G
Y
W
K
R
S
G
K
M
Site 69
S862
G
Q
R
V
L
L
F
S
Q
S
R
Q
M
L
D
Site 70
Y880
V
F
L
R
A
Q
K
Y
T
Y
L
K
M
D
G
Site 71
Y882
L
R
A
Q
K
Y
T
Y
L
K
M
D
G
T
T
Site 72
T888
T
Y
L
K
M
D
G
T
T
T
I
A
S
R
Q
Site 73
S893
D
G
T
T
T
I
A
S
R
Q
P
L
I
T
R
Site 74
T899
A
S
R
Q
P
L
I
T
R
Y
N
E
D
T
S
Site 75
Y901
R
Q
P
L
I
T
R
Y
N
E
D
T
S
I
F
Site 76
Y932
G
A
N
R
V
V
I
Y
D
P
D
W
N
P
S
Site 77
T942
D
W
N
P
S
T
D
T
Q
A
R
E
R
A
W
Site 78
T958
I
G
Q
K
K
Q
V
T
V
Y
R
L
L
T
A
Site 79
Y973
G
T
I
E
E
K
I
Y
H
R
Q
I
F
K
Q
Site 80
T983
Q
I
F
K
Q
F
L
T
N
R
V
L
K
D
P
Site 81
S998
K
Q
R
R
F
F
K
S
N
D
L
Y
E
L
F
Site 82
Y1002
F
F
K
S
N
D
L
Y
E
L
F
T
L
T
S
Site 83
T1006
N
D
L
Y
E
L
F
T
L
T
S
P
D
A
S
Site 84
T1008
L
Y
E
L
F
T
L
T
S
P
D
A
S
Q
S
Site 85
S1009
Y
E
L
F
T
L
T
S
P
D
A
S
Q
S
T
Site 86
S1013
T
L
T
S
P
D
A
S
Q
S
T
E
T
S
A
Site 87
S1015
T
S
P
D
A
S
Q
S
T
E
T
S
A
I
F
Site 88
S1019
A
S
Q
S
T
E
T
S
A
I
F
A
G
T
G
Site 89
T1031
G
T
G
S
D
V
Q
T
P
K
C
H
L
K
R
Site 90
S1059
K
R
K
K
F
P
A
S
N
I
S
V
N
D
A
Site 91
S1062
K
F
P
A
S
N
I
S
V
N
D
A
T
S
S
Site 92
S1068
I
S
V
N
D
A
T
S
S
E
E
K
S
E
A
Site 93
S1069
S
V
N
D
A
T
S
S
E
E
K
S
E
A
K
Site 94
S1073
A
T
S
S
E
E
K
S
E
A
K
G
A
E
V
Site 95
S1085
A
E
V
N
A
V
T
S
N
R
S
D
P
L
K
Site 96
S1098
L
K
D
D
P
H
M
S
S
N
V
T
S
N
D
Site 97
S1099
K
D
D
P
H
M
S
S
N
V
T
S
N
D
R
Site 98
T1102
P
H
M
S
S
N
V
T
S
N
D
R
L
G
E
Site 99
S1103
H
M
S
S
N
V
T
S
N
D
R
L
G
E
E
Site 100
T1111
N
D
R
L
G
E
E
T
N
A
V
S
G
P
E
Site 101
S1115
G
E
E
T
N
A
V
S
G
P
E
E
L
S
V
Site 102
S1121
V
S
G
P
E
E
L
S
V
I
S
G
N
G
E
Site 103
S1124
P
E
E
L
S
V
I
S
G
N
G
E
C
S
N
Site 104
S1130
I
S
G
N
G
E
C
S
N
S
S
G
T
G
K
Site 105
S1132
G
N
G
E
C
S
N
S
S
G
T
G
K
T
S
Site 106
S1133
N
G
E
C
S
N
S
S
G
T
G
K
T
S
M
Site 107
T1138
N
S
S
G
T
G
K
T
S
M
P
S
G
D
E
Site 108
S1139
S
S
G
T
G
K
T
S
M
P
S
G
D
E
S
Site 109
S1142
T
G
K
T
S
M
P
S
G
D
E
S
I
D
E
Site 110
S1146
S
M
P
S
G
D
E
S
I
D
E
K
L
G
L
Site 111
S1154
I
D
E
K
L
G
L
S
Y
K
R
E
R
P
S
Site 112
Y1155
D
E
K
L
G
L
S
Y
K
R
E
R
P
S
Q
Site 113
S1161
S
Y
K
R
E
R
P
S
Q
A
Q
T
E
A
F
Site 114
T1165
E
R
P
S
Q
A
Q
T
E
A
F
W
E
N
K
Site 115
Y1179
K
Q
M
E
N
N
F
Y
K
H
K
S
K
T
K
Site 116
T1185
F
Y
K
H
K
S
K
T
K
H
H
S
V
A
E
Site 117
S1189
K
S
K
T
K
H
H
S
V
A
E
E
E
T
L
Site 118
S1209
P
K
Q
K
P
K
N
S
K
H
C
R
D
A
K
Site 119
T1220
R
D
A
K
F
E
G
T
R
I
P
H
L
V
K
Site 120
Y1231
H
L
V
K
K
R
R
Y
Q
K
Q
D
S
E
N
Site 121
S1236
R
R
Y
Q
K
Q
D
S
E
N
K
S
E
A
K
Site 122
S1240
K
Q
D
S
E
N
K
S
E
A
K
E
Q
S
N
Site 123
Y1250
K
E
Q
S
N
D
D
Y
V
L
E
K
L
F
K
Site 124
S1264
K
K
S
V
G
V
H
S
V
M
K
H
D
A
I
Site 125
Y1279
M
D
G
A
S
P
D
Y
V
L
V
E
A
E
A
Site 126
S1300
A
L
K
A
L
R
L
S
R
Q
R
C
L
G
A
Site 127
T1313
G
A
V
S
G
V
P
T
W
T
G
H
R
G
I
Site 128
T1315
V
S
G
V
P
T
W
T
G
H
R
G
I
S
G
Site 129
S1321
W
T
G
H
R
G
I
S
G
A
P
A
G
K
K
Site 130
S1329
G
A
P
A
G
K
K
S
R
F
G
K
K
R
N
Site 131
S1337
R
F
G
K
K
R
N
S
N
F
S
V
Q
H
P
Site 132
S1340
K
K
R
N
S
N
F
S
V
Q
H
P
S
S
T
Site 133
S1345
N
F
S
V
Q
H
P
S
S
T
S
P
T
E
K
Site 134
S1346
F
S
V
Q
H
P
S
S
T
S
P
T
E
K
C
Site 135
T1347
S
V
Q
H
P
S
S
T
S
P
T
E
K
C
Q
Site 136
S1348
V
Q
H
P
S
S
T
S
P
T
E
K
C
Q
D
Site 137
T1350
H
P
S
S
T
S
P
T
E
K
C
Q
D
G
I
Site 138
S1379
G
R
A
E
D
A
D
S
S
S
G
P
L
A
S
Site 139
S1380
R
A
E
D
A
D
S
S
S
G
P
L
A
S
S
Site 140
S1381
A
E
D
A
D
S
S
S
G
P
L
A
S
S
S
Site 141
S1407
I
L
P
E
R
L
E
S
E
S
G
H
L
Q
E
Site 142
S1409
P
E
R
L
E
S
E
S
G
H
L
Q
E
A
S
Site 143
S1446
A
H
T
D
G
Q
A
S
T
R
E
I
L
Q
E
Site 144
S1456
E
I
L
Q
E
F
E
S
K
L
S
A
S
Q
S
Site 145
S1459
Q
E
F
E
S
K
L
S
A
S
Q
S
C
V
F
Site 146
S1461
F
E
S
K
L
S
A
S
Q
S
C
V
F
R
E
Site 147
T1475
E
L
L
R
N
L
C
T
F
H
R
T
S
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation