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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSF2
Full Name:
Heat shock factor protein 2
Alias:
Heat shock transcription factor 2; HSF 2; HSTF 2; HSTF2
Type:
Cytoplasm, Nucleus protein
Mass (Da):
60348
Number AA:
536
UniProt ID:
Q03933
International Prot ID:
IPI00012878
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003713
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006950
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
T
L
V
E
E
T
H
T
N
E
F
I
T
W
S
Site 2
S35
T
W
S
Q
N
G
Q
S
F
L
V
L
D
E
Q
Site 3
Y52
A
K
E
I
L
P
K
Y
F
K
H
N
N
M
A
Site 4
Y68
F
V
R
Q
L
N
M
Y
G
F
R
K
V
V
H
Site 5
S78
R
K
V
V
H
I
D
S
G
I
V
K
Q
E
R
Site 6
Y95
P
V
E
F
Q
H
P
Y
F
K
Q
G
Q
D
D
Site 7
S112
E
N
I
K
R
K
V
S
S
S
K
P
E
E
N
Site 8
S113
N
I
K
R
K
V
S
S
S
K
P
E
E
N
K
Site 9
S114
I
K
R
K
V
S
S
S
K
P
E
E
N
K
I
Site 10
T127
K
I
R
Q
E
D
L
T
K
I
I
S
S
A
Q
Site 11
S131
E
D
L
T
K
I
I
S
S
A
Q
K
V
Q
I
Site 12
S145
I
K
Q
E
T
I
E
S
R
L
S
E
L
K
S
Site 13
S148
E
T
I
E
S
R
L
S
E
L
K
S
E
N
E
Site 14
S152
S
R
L
S
E
L
K
S
E
N
E
S
L
W
K
Site 15
S156
E
L
K
S
E
N
E
S
L
W
K
E
V
S
E
Site 16
S162
E
S
L
W
K
E
V
S
E
L
R
A
K
H
A
Site 17
S193
V
Q
N
N
Q
L
V
S
L
K
R
K
R
P
L
Site 18
S231
H
H
H
K
V
P
H
S
R
T
E
G
L
K
P
Site 19
S243
L
K
P
R
E
R
I
S
D
D
I
I
I
Y
D
Site 20
Y249
I
S
D
D
I
I
I
Y
D
V
T
D
D
N
A
Site 21
T252
D
I
I
I
Y
D
V
T
D
D
N
A
D
E
E
Site 22
T267
N
I
P
V
I
P
E
T
N
E
D
V
I
S
D
Site 23
S273
E
T
N
E
D
V
I
S
D
P
S
N
C
S
Q
Site 24
S276
E
D
V
I
S
D
P
S
N
C
S
Q
Y
P
D
Site 25
S279
I
S
D
P
S
N
C
S
Q
Y
P
D
I
V
I
Site 26
Y281
D
P
S
N
C
S
Q
Y
P
D
I
V
I
V
E
Site 27
Y295
E
D
D
N
E
D
E
Y
A
P
V
I
Q
S
G
Site 28
S311
Q
N
E
P
A
R
E
S
L
S
S
G
S
D
G
Site 29
S313
E
P
A
R
E
S
L
S
S
G
S
D
G
S
S
Site 30
S314
P
A
R
E
S
L
S
S
G
S
D
G
S
S
P
Site 31
S316
R
E
S
L
S
S
G
S
D
G
S
S
P
L
M
Site 32
S319
L
S
S
G
S
D
G
S
S
P
L
M
S
S
A
Site 33
S320
S
S
G
S
D
G
S
S
P
L
M
S
S
A
V
Site 34
S324
D
G
S
S
P
L
M
S
S
A
V
Q
L
N
G
Site 35
S325
G
S
S
P
L
M
S
S
A
V
Q
L
N
G
S
Site 36
S332
S
A
V
Q
L
N
G
S
S
S
L
T
S
E
D
Site 37
S334
V
Q
L
N
G
S
S
S
L
T
S
E
D
P
V
Site 38
T336
L
N
G
S
S
S
L
T
S
E
D
P
V
T
M
Site 39
S337
N
G
S
S
S
L
T
S
E
D
P
V
T
M
M
Site 40
T342
L
T
S
E
D
P
V
T
M
M
D
S
I
L
N
Site 41
Y363
G
K
V
E
L
L
D
Y
L
D
S
I
D
C
S
Site 42
S366
E
L
L
D
Y
L
D
S
I
D
C
S
L
E
D
Site 43
S370
Y
L
D
S
I
D
C
S
L
E
D
F
Q
A
M
Site 44
S379
E
D
F
Q
A
M
L
S
G
R
Q
F
S
I
D
Site 45
S397
L
V
D
L
F
T
S
S
V
Q
M
N
P
T
D
Site 46
Y405
V
Q
M
N
P
T
D
Y
I
N
N
T
K
S
E
Site 47
S411
D
Y
I
N
N
T
K
S
E
N
K
G
L
E
T
Site 48
S428
N
N
V
V
Q
P
V
S
E
E
G
R
K
S
K
Site 49
S434
V
S
E
E
G
R
K
S
K
S
K
P
D
K
Q
Site 50
S436
E
E
G
R
K
S
K
S
K
P
D
K
Q
L
I
Site 51
S460
F
L
D
G
N
P
A
S
S
V
E
Q
A
S
T
Site 52
S466
A
S
S
V
E
Q
A
S
T
T
A
S
S
E
V
Site 53
T467
S
S
V
E
Q
A
S
T
T
A
S
S
E
V
L
Site 54
S470
E
Q
A
S
T
T
A
S
S
E
V
L
S
S
V
Site 55
S471
Q
A
S
T
T
A
S
S
E
V
L
S
S
V
D
Site 56
S475
T
A
S
S
E
V
L
S
S
V
D
K
P
I
E
Site 57
S476
A
S
S
E
V
L
S
S
V
D
K
P
I
E
V
Site 58
S489
E
V
D
E
L
L
D
S
S
L
D
P
E
P
T
Site 59
S490
V
D
E
L
L
D
S
S
L
D
P
E
P
T
Q
Site 60
T496
S
S
L
D
P
E
P
T
Q
S
K
L
V
R
L
Site 61
S498
L
D
P
E
P
T
Q
S
K
L
V
R
L
E
P
Site 62
T507
L
V
R
L
E
P
L
T
E
A
E
A
S
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation