KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NFkB-p65
Full Name:
Transcription factor p65
Alias:
NFKB3; Nuclear factor NF-kappa-B p65 subunit; P65; RELA; TF65; V-rel reticuloendotheliosis viral oncogene A
Type:
Nuclear receptor co-regulator; Transcription factor
Mass (Da):
60219
Number AA:
551
UniProt ID:
Q04206
International Prot ID:
IPI00386448
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0003705
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006968
GO:0019221
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
P
A
Q
A
S
G
P
Y
V
E
I
I
E
Q
P
Site 2
Y36
Q
R
G
M
R
F
R
Y
K
C
E
G
R
S
A
Site 3
S42
R
Y
K
C
E
G
R
S
A
G
S
I
P
G
E
Site 4
S45
C
E
G
R
S
A
G
S
I
P
G
E
R
S
T
Site 5
T52
S
I
P
G
E
R
S
T
D
T
T
K
T
H
P
Site 6
T54
P
G
E
R
S
T
D
T
T
K
T
H
P
T
I
Site 7
T55
G
E
R
S
T
D
T
T
K
T
H
P
T
I
K
Site 8
T57
R
S
T
D
T
T
K
T
H
P
T
I
K
I
N
Site 9
Y66
P
T
I
K
I
N
G
Y
T
G
P
G
T
V
R
Site 10
S75
G
P
G
T
V
R
I
S
L
V
T
K
D
P
P
Site 11
T78
T
V
R
I
S
L
V
T
K
D
P
P
H
R
P
Site 12
Y100
K
D
C
R
D
G
F
Y
E
A
E
L
C
P
D
Site 13
S131
R
D
L
E
Q
A
I
S
Q
R
I
Q
T
N
N
Site 14
T136
A
I
S
Q
R
I
Q
T
N
N
N
P
F
Q
V
Site 15
Y152
I
E
E
Q
R
G
D
Y
D
L
N
A
V
R
L
Site 16
T164
V
R
L
C
F
Q
V
T
V
R
D
P
S
G
R
Site 17
S169
Q
V
T
V
R
D
P
S
G
R
P
L
R
L
P
Site 18
S180
L
R
L
P
P
V
L
S
H
P
I
F
D
N
R
Site 19
S203
I
C
R
V
N
R
N
S
G
S
C
L
G
G
D
Site 20
S205
R
V
N
R
N
S
G
S
C
L
G
G
D
E
I
Site 21
Y227
Q
K
E
D
I
E
V
Y
F
T
G
P
G
W
E
Site 22
T229
E
D
I
E
V
Y
F
T
G
P
G
W
E
A
R
Site 23
S238
P
G
W
E
A
R
G
S
F
S
Q
A
D
V
H
Site 24
S240
W
E
A
R
G
S
F
S
Q
A
D
V
H
R
Q
Site 25
T254
Q
V
A
I
V
F
R
T
P
P
Y
A
D
P
S
Site 26
Y257
I
V
F
R
T
P
P
Y
A
D
P
S
L
Q
A
Site 27
S261
T
P
P
Y
A
D
P
S
L
Q
A
P
V
R
V
Site 28
S269
L
Q
A
P
V
R
V
S
M
Q
L
R
R
P
S
Site 29
S276
S
M
Q
L
R
R
P
S
D
R
E
L
S
E
P
Site 30
S281
R
P
S
D
R
E
L
S
E
P
M
E
F
Q
Y
Site 31
Y288
S
E
P
M
E
F
Q
Y
L
P
D
T
D
D
R
Site 32
T292
E
F
Q
Y
L
P
D
T
D
D
R
H
R
I
E
Site 33
T305
I
E
E
K
R
K
R
T
Y
E
T
F
K
S
I
Site 34
Y306
E
E
K
R
K
R
T
Y
E
T
F
K
S
I
M
Site 35
T308
K
R
K
R
T
Y
E
T
F
K
S
I
M
K
K
Site 36
S311
R
T
Y
E
T
F
K
S
I
M
K
K
S
P
F
Site 37
S316
F
K
S
I
M
K
K
S
P
F
S
G
P
T
D
Site 38
S319
I
M
K
K
S
P
F
S
G
P
T
D
P
R
P
Site 39
T322
K
S
P
F
S
G
P
T
D
P
R
P
P
P
R
Site 40
S335
P
R
R
I
A
V
P
S
R
S
S
A
S
V
P
Site 41
S337
R
I
A
V
P
S
R
S
S
A
S
V
P
K
P
Site 42
S338
I
A
V
P
S
R
S
S
A
S
V
P
K
P
A
Site 43
S340
V
P
S
R
S
S
A
S
V
P
K
P
A
P
Q
Site 44
Y349
P
K
P
A
P
Q
P
Y
P
F
T
S
S
L
S
Site 45
T352
A
P
Q
P
Y
P
F
T
S
S
L
S
T
I
N
Site 46
S353
P
Q
P
Y
P
F
T
S
S
L
S
T
I
N
Y
Site 47
S354
Q
P
Y
P
F
T
S
S
L
S
T
I
N
Y
D
Site 48
Y360
S
S
L
S
T
I
N
Y
D
E
F
P
T
M
V
Site 49
T435
P
T
Q
A
G
E
G
T
L
S
E
A
L
L
Q
Site 50
S437
Q
A
G
E
G
T
L
S
E
A
L
L
Q
L
Q
Site 51
T464
S
T
D
P
A
V
F
T
D
L
A
S
V
D
N
Site 52
S468
A
V
F
T
D
L
A
S
V
D
N
S
E
F
Q
Site 53
S472
D
L
A
S
V
D
N
S
E
F
Q
Q
L
L
N
Site 54
Y496
T
E
P
M
L
M
E
Y
P
E
A
I
T
R
L
Site 55
T505
E
A
I
T
R
L
V
T
G
A
Q
R
P
P
D
Site 56
S529
G
L
P
N
G
L
L
S
G
D
E
D
F
S
S
Site 57
S536
S
G
D
E
D
F
S
S
I
A
D
M
D
F
S
Site 58
S547
M
D
F
S
A
L
L
S
Q
I
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation