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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GBE1
Full Name:
1,4-alpha-glucan-branching enzyme
Alias:
1,4-alpha-glucan branching enzyme; Andersen disease; brancher enzyme; GLGB; glucan (1,4-alpha-) branching enzyme 1; glycogen branching enzyme; glycogen storage disease type IV
Type:
Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.18; Transferase
Mass (Da):
80460
Number AA:
702
UniProt ID:
Q04446
International Prot ID:
IPI00296635
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003844
GO:0043169
GO:0004553
PhosphoSite+
KinaseNET
Biological Process:
GO:0005978
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
A
P
M
T
P
A
A
R
P
E
D
Site 2
Y14
P
A
A
R
P
E
D
Y
E
A
A
L
N
A
A
Site 3
Y37
R
L
L
E
I
D
P
Y
L
K
P
Y
A
V
D
Site 4
Y41
I
D
P
Y
L
K
P
Y
A
V
D
F
Q
R
R
Site 5
Y49
A
V
D
F
Q
R
R
Y
K
Q
F
S
Q
I
L
Site 6
S53
Q
R
R
Y
K
Q
F
S
Q
I
L
K
N
I
G
Site 7
S70
E
G
G
I
D
K
F
S
R
G
Y
E
S
F
G
Site 8
Y73
I
D
K
F
S
R
G
Y
E
S
F
G
V
H
R
Site 9
S75
K
F
S
R
G
Y
E
S
F
G
V
H
R
C
A
Site 10
Y87
R
C
A
D
G
G
L
Y
C
K
E
W
A
P
G
Site 11
Y112
N
G
W
N
P
F
S
Y
P
Y
K
K
L
D
Y
Site 12
Y119
Y
P
Y
K
K
L
D
Y
G
K
W
E
L
Y
I
Site 13
Y125
D
Y
G
K
W
E
L
Y
I
P
P
K
Q
N
K
Site 14
S133
I
P
P
K
Q
N
K
S
V
L
V
P
H
G
S
Site 15
Y155
S
K
S
G
E
I
L
Y
R
I
S
P
W
A
K
Site 16
Y163
R
I
S
P
W
A
K
Y
V
V
R
E
G
D
N
Site 17
Y173
R
E
G
D
N
V
N
Y
D
W
I
H
W
D
P
Site 18
Y184
H
W
D
P
E
H
S
Y
E
F
K
H
S
R
P
Site 19
S189
H
S
Y
E
F
K
H
S
R
P
K
K
P
R
S
Site 20
S196
S
R
P
K
K
P
R
S
L
R
I
Y
E
S
H
Site 21
Y200
K
P
R
S
L
R
I
Y
E
S
H
V
G
I
S
Site 22
S202
R
S
L
R
I
Y
E
S
H
V
G
I
S
S
H
Site 23
S208
E
S
H
V
G
I
S
S
H
E
G
K
V
A
S
Site 24
Y245
M
A
I
M
E
H
A
Y
Y
A
S
F
G
Y
Q
Site 25
S255
S
F
G
Y
Q
I
T
S
F
F
A
A
S
S
R
Site 26
S260
I
T
S
F
F
A
A
S
S
R
Y
G
T
P
E
Site 27
S261
T
S
F
F
A
A
S
S
R
Y
G
T
P
E
E
Site 28
Y263
F
F
A
A
S
S
R
Y
G
T
P
E
E
L
Q
Site 29
T265
A
A
S
S
R
Y
G
T
P
E
E
L
Q
E
L
Site 30
Y310
F
D
G
T
D
S
C
Y
F
H
S
G
P
R
G
Site 31
T318
F
H
S
G
P
R
G
T
H
D
L
W
D
S
R
Site 32
S330
D
S
R
L
F
A
Y
S
S
W
E
V
L
R
F
Site 33
Y364
D
G
V
T
S
M
L
Y
H
H
H
G
V
G
Q
Site 34
S374
H
G
V
G
Q
G
F
S
G
D
Y
S
E
Y
F
Site 35
Y377
G
Q
G
F
S
G
D
Y
S
E
Y
F
G
L
Q
Site 36
S378
Q
G
F
S
G
D
Y
S
E
Y
F
G
L
Q
V
Site 37
Y380
F
S
G
D
Y
S
E
Y
F
G
L
Q
V
D
E
Site 38
T391
Q
V
D
E
D
A
L
T
Y
L
M
L
A
N
H
Site 39
S425
P
A
L
C
S
P
I
S
Q
G
G
G
G
F
D
Site 40
Y462
W
N
M
G
D
I
V
Y
T
L
T
N
R
R
Y
Site 41
T465
G
D
I
V
Y
T
L
T
N
R
R
Y
L
E
K
Site 42
Y469
Y
T
L
T
N
R
R
Y
L
E
K
C
I
A
Y
Site 43
Y476
Y
L
E
K
C
I
A
Y
A
E
S
H
D
Q
A
Site 44
T527
H
K
M
I
R
L
I
T
H
G
L
G
G
E
G
Site 45
Y535
H
G
L
G
G
E
G
Y
L
N
F
M
G
N
E
Site 46
S559
P
R
K
G
N
N
E
S
Y
H
Y
A
R
R
Q
Site 47
Y560
R
K
G
N
N
E
S
Y
H
Y
A
R
R
Q
F
Site 48
Y562
G
N
N
E
S
Y
H
Y
A
R
R
Q
F
H
L
Site 49
T570
A
R
R
Q
F
H
L
T
D
D
D
L
L
R
Y
Site 50
Y603
W
L
A
A
P
Q
A
Y
V
S
E
K
H
E
G
Site 51
S632
F
N
F
H
P
S
K
S
Y
T
D
Y
R
V
G
Site 52
T634
F
H
P
S
K
S
Y
T
D
Y
R
V
G
T
A
Site 53
Y636
P
S
K
S
Y
T
D
Y
R
V
G
T
A
L
P
Site 54
T640
Y
T
D
Y
R
V
G
T
A
L
P
G
K
F
K
Site 55
S652
K
F
K
I
V
L
D
S
D
A
A
E
Y
G
G
Site 56
Y657
L
D
S
D
A
A
E
Y
G
G
H
Q
R
L
D
Site 57
S666
G
H
Q
R
L
D
H
S
T
D
F
F
S
E
A
Site 58
T667
H
Q
R
L
D
H
S
T
D
F
F
S
E
A
F
Site 59
Y681
F
E
H
N
G
R
P
Y
S
L
L
V
Y
I
P
Site 60
S682
E
H
N
G
R
P
Y
S
L
L
V
Y
I
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation