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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF4G1
Full Name:
Eukaryotic translation initiation factor 4 gamma 1
Alias:
EIF4F; EIF4G; EIF-4G; EIF-4G 1; EIF-4G1; EIF-4-gamma 1; EIF4GI; Eukaryotic translation initiation factor 4 gamma, 1; Eukaryotic translation initiation factor 4GI; IF4G1; P220
Type:
Protein synthesis protein
Mass (Da):
175535
Number AA:
1600
UniProt ID:
Q04637
International Prot ID:
IPI00552639
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016281
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0016070
GO:0044419
GO:0006446
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
N
K
A
P
Q
S
T
G
P
P
P
A
P
Site 2
S15
T
G
P
P
P
A
P
S
P
G
L
P
Q
P
A
Site 3
T35
T
A
P
V
V
F
S
T
P
Q
A
T
Q
M
N
Site 4
T43
P
Q
A
T
Q
M
N
T
P
S
Q
P
R
Q
H
Site 5
Y52
S
Q
P
R
Q
H
F
Y
P
S
R
A
Q
P
P
Site 6
S54
P
R
Q
H
F
Y
P
S
R
A
Q
P
P
S
S
Site 7
S60
P
S
R
A
Q
P
P
S
S
A
A
S
R
V
Q
Site 8
S61
S
R
A
Q
P
P
S
S
A
A
S
R
V
Q
S
Site 9
S64
Q
P
P
S
S
A
A
S
R
V
Q
S
A
A
P
Site 10
S68
S
A
A
S
R
V
Q
S
A
A
P
A
R
P
G
Site 11
Y81
P
G
P
A
A
H
V
Y
P
A
G
S
Q
V
M
Site 12
S95
M
M
I
P
S
Q
I
S
Y
P
A
S
Q
G
A
Site 13
Y96
M
I
P
S
Q
I
S
Y
P
A
S
Q
G
A
Y
Site 14
S99
S
Q
I
S
Y
P
A
S
Q
G
A
Y
Y
I
P
Site 15
Y103
Y
P
A
S
Q
G
A
Y
Y
I
P
G
Q
G
R
Site 16
Y104
P
A
S
Q
G
A
Y
Y
I
P
G
Q
G
R
S
Site 17
S111
Y
I
P
G
Q
G
R
S
T
Y
V
V
P
T
Q
Site 18
T112
I
P
G
Q
G
R
S
T
Y
V
V
P
T
Q
Q
Site 19
Y113
P
G
Q
G
R
S
T
Y
V
V
P
T
Q
Q
Y
Site 20
Y120
Y
V
V
P
T
Q
Q
Y
P
V
Q
P
G
A
P
Site 21
Y130
Q
P
G
A
P
G
F
Y
P
G
A
S
P
T
E
Site 22
S134
P
G
F
Y
P
G
A
S
P
T
E
L
G
T
Y
Site 23
Y141
S
P
T
E
L
G
T
Y
A
G
A
Y
Y
P
A
Site 24
Y145
L
G
T
Y
A
G
A
Y
Y
P
A
R
G
V
Q
Site 25
Y146
G
T
Y
A
G
A
Y
Y
P
A
R
G
V
Q
Q
Site 26
T179
A
P
K
R
E
R
K
T
I
R
I
R
D
P
N
Site 27
T193
N
Q
G
G
K
D
I
T
E
E
I
M
S
G
A
Site 28
S198
D
I
T
E
E
I
M
S
G
A
R
T
A
S
T
Site 29
T202
E
I
M
S
G
A
R
T
A
S
T
P
T
P
P
Site 30
S204
M
S
G
A
R
T
A
S
T
P
T
P
P
Q
T
Site 31
T205
S
G
A
R
T
A
S
T
P
T
P
P
Q
T
G
Site 32
T207
A
R
T
A
S
T
P
T
P
P
Q
T
G
G
G
Site 33
T211
S
T
P
T
P
P
Q
T
G
G
G
L
E
P
Q
Site 34
T223
E
P
Q
A
N
G
E
T
P
Q
V
A
V
I
V
Site 35
S236
I
V
R
P
D
D
R
S
Q
G
A
I
I
A
D
Site 36
S253
G
L
P
G
P
E
H
S
P
S
E
S
Q
P
S
Site 37
S255
P
G
P
E
H
S
P
S
E
S
Q
P
S
S
P
Site 38
S257
P
E
H
S
P
S
E
S
Q
P
S
S
P
S
P
Site 39
S260
S
P
S
E
S
Q
P
S
S
P
S
P
T
P
S
Site 40
S261
P
S
E
S
Q
P
S
S
P
S
P
T
P
S
P
Site 41
S263
E
S
Q
P
S
S
P
S
P
T
P
S
P
S
P
Site 42
T265
Q
P
S
S
P
S
P
T
P
S
P
S
P
V
L
Site 43
S267
S
S
P
S
P
T
P
S
P
S
P
V
L
E
P
Site 44
S269
P
S
P
T
P
S
P
S
P
V
L
E
P
G
S
Site 45
S276
S
P
V
L
E
P
G
S
E
P
N
L
A
V
L
Site 46
T291
S
I
P
G
D
T
M
T
T
I
Q
M
S
V
E
Site 47
S296
T
M
T
T
I
Q
M
S
V
E
E
S
T
P
I
Site 48
S300
I
Q
M
S
V
E
E
S
T
P
I
S
R
E
T
Site 49
T301
Q
M
S
V
E
E
S
T
P
I
S
R
E
T
G
Site 50
S304
V
E
E
S
T
P
I
S
R
E
T
G
E
P
Y
Site 51
T307
S
T
P
I
S
R
E
T
G
E
P
Y
R
L
S
Site 52
Y311
S
R
E
T
G
E
P
Y
R
L
S
P
E
P
T
Site 53
S314
T
G
E
P
Y
R
L
S
P
E
P
T
P
L
A
Site 54
T318
Y
R
L
S
P
E
P
T
P
L
A
E
P
I
L
Site 55
S332
L
E
V
E
V
T
L
S
K
P
V
P
E
S
E
Site 56
S338
L
S
K
P
V
P
E
S
E
F
S
S
S
P
L
Site 57
S341
P
V
P
E
S
E
F
S
S
S
P
L
Q
A
P
Site 58
S342
V
P
E
S
E
F
S
S
S
P
L
Q
A
P
T
Site 59
S343
P
E
S
E
F
S
S
S
P
L
Q
A
P
T
P
Site 60
T349
S
S
P
L
Q
A
P
T
P
L
A
S
H
T
V
Site 61
S353
Q
A
P
T
P
L
A
S
H
T
V
E
I
H
E
Site 62
T355
P
T
P
L
A
S
H
T
V
E
I
H
E
P
N
Site 63
S367
E
P
N
G
M
V
P
S
E
D
L
E
P
E
V
Site 64
S377
L
E
P
E
V
E
S
S
P
E
L
A
P
P
P
Site 65
S388
A
P
P
P
A
C
P
S
E
S
P
V
P
I
A
Site 66
S390
P
P
A
C
P
S
E
S
P
V
P
I
A
P
T
Site 67
S409
E
L
L
N
G
A
P
S
P
P
A
V
D
L
S
Site 68
S416
S
P
P
A
V
D
L
S
P
V
S
E
P
E
E
Site 69
S419
A
V
D
L
S
P
V
S
E
P
E
E
Q
A
K
Site 70
S431
Q
A
K
E
V
T
A
S
V
A
P
P
T
I
P
Site 71
T441
P
P
T
I
P
S
A
T
P
A
T
A
P
S
A
Site 72
S450
A
T
A
P
S
A
T
S
P
A
Q
E
E
E
M
Site 73
S488
E
E
L
L
P
P
E
S
T
P
I
P
A
N
L
Site 74
T489
E
L
L
P
P
E
S
T
P
I
P
A
N
L
S
Site 75
S496
T
P
I
P
A
N
L
S
Q
N
L
E
A
A
A
Site 76
S552
E
N
Q
P
P
A
G
S
N
P
G
P
E
S
E
Site 77
S558
G
S
N
P
G
P
E
S
E
G
S
G
V
P
P
Site 78
S561
P
G
P
E
S
E
G
S
G
V
P
P
R
P
E
Site 79
T573
R
P
E
E
A
D
E
T
W
D
S
K
E
D
K
Site 80
S576
E
A
D
E
T
W
D
S
K
E
D
K
I
H
N
Site 81
Y594
I
Q
P
G
E
Q
K
Y
E
Y
K
S
D
Q
W
Site 82
Y596
P
G
E
Q
K
Y
E
Y
K
S
D
Q
W
K
P
Site 83
Y612
N
L
E
E
K
K
R
Y
D
R
E
F
L
L
G
Site 84
S637
P
E
G
L
P
H
I
S
D
V
V
L
D
K
A
Site 85
T647
V
L
D
K
A
N
K
T
P
L
R
P
L
D
P
Site 86
T655
P
L
R
P
L
D
P
T
R
L
Q
G
I
N
C
Site 87
S669
C
G
P
D
F
T
P
S
F
A
N
L
G
R
T
Site 88
T677
F
A
N
L
G
R
T
T
L
S
T
R
G
P
P
Site 89
S679
N
L
G
R
T
T
L
S
T
R
G
P
P
R
G
Site 90
T680
L
G
R
T
T
L
S
T
R
G
P
P
R
G
G
Site 91
S973
I
I
K
E
K
K
T
S
S
R
I
R
F
M
L
Site 92
S1098
R
L
S
W
G
K
G
S
S
G
G
S
G
A
K
Site 93
S1145
N
R
R
V
V
Q
R
S
S
L
S
R
E
R
G
Site 94
Y1316
G
H
L
S
T
A
Q
Y
Y
Q
G
L
Y
E
I
Site 95
S1456
E
K
L
L
K
E
G
S
S
N
Q
R
V
F
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation