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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLE1
Full Name:
Transducin-like enhancer protein 1
Alias:
Enhancer of split groucho-like protein 1; ESG1;
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
83201
Number AA:
770
UniProt ID:
Q04724
International Prot ID:
IPI00413270
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0030178
GO:0009887
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
F
P
Q
S
R
H
P
T
P
H
Q
A
A
G
Q
Site 2
T21
A
G
Q
P
F
K
F
T
I
P
E
S
L
D
R
Site 3
S25
F
K
F
T
I
P
E
S
L
D
R
I
K
E
E
Site 4
S52
L
E
C
E
K
L
A
S
E
K
T
E
M
Q
R
Site 5
T55
E
K
L
A
S
E
K
T
E
M
Q
R
H
Y
V
Site 6
Y61
K
T
E
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Site 7
Y64
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
Site 8
Y65
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
N
Site 9
S97
A
Q
V
I
P
F
L
S
Q
E
H
Q
Q
Q
V
Site 10
S134
Q
L
Q
A
Q
H
L
S
H
G
H
G
P
P
V
Site 11
T144
H
G
P
P
V
P
L
T
P
H
P
S
G
L
Q
Site 12
S148
V
P
L
T
P
H
P
S
G
L
Q
P
P
G
I
Site 13
S199
R
D
R
E
P
G
T
S
N
S
L
L
V
P
D
Site 14
S201
R
E
P
G
T
S
N
S
L
L
V
P
D
S
L
Site 15
S207
N
S
L
L
V
P
D
S
L
R
G
T
D
K
R
Site 16
T211
V
P
D
S
L
R
G
T
D
K
R
R
N
G
P
Site 17
S221
R
R
N
G
P
E
F
S
N
D
I
K
K
R
K
Site 18
S234
R
K
V
D
D
K
D
S
S
H
Y
D
S
D
G
Site 19
S235
K
V
D
D
K
D
S
S
H
Y
D
S
D
G
D
Site 20
Y237
D
D
K
D
S
S
H
Y
D
S
D
G
D
K
S
Site 21
S239
K
D
S
S
H
Y
D
S
D
G
D
K
S
D
D
Site 22
S244
Y
D
S
D
G
D
K
S
D
D
N
L
V
V
D
Site 23
S253
D
N
L
V
V
D
V
S
N
E
D
P
S
S
P
Site 24
S258
D
V
S
N
E
D
P
S
S
P
R
A
S
P
A
Site 25
S259
V
S
N
E
D
P
S
S
P
R
A
S
P
A
H
Site 26
S263
D
P
S
S
P
R
A
S
P
A
H
S
P
R
E
Site 27
S267
P
R
A
S
P
A
H
S
P
R
E
N
G
I
D
Site 28
S284
R
L
L
K
K
D
A
S
S
S
P
A
S
T
A
Site 29
S285
L
L
K
K
D
A
S
S
S
P
A
S
T
A
S
Site 30
S286
L
K
K
D
A
S
S
S
P
A
S
T
A
S
S
Site 31
S289
D
A
S
S
S
P
A
S
T
A
S
S
A
S
S
Site 32
T290
A
S
S
S
P
A
S
T
A
S
S
A
S
S
T
Site 33
S292
S
S
P
A
S
T
A
S
S
A
S
S
T
S
L
Site 34
S293
S
P
A
S
T
A
S
S
A
S
S
T
S
L
K
Site 35
S296
S
T
A
S
S
A
S
S
T
S
L
K
S
K
E
Site 36
T297
T
A
S
S
A
S
S
T
S
L
K
S
K
E
M
Site 37
S298
A
S
S
A
S
S
T
S
L
K
S
K
E
M
S
Site 38
S301
A
S
S
T
S
L
K
S
K
E
M
S
L
H
E
Site 39
S305
S
L
K
S
K
E
M
S
L
H
E
K
A
S
T
Site 40
S311
M
S
L
H
E
K
A
S
T
P
V
L
K
S
S
Site 41
T312
S
L
H
E
K
A
S
T
P
V
L
K
S
S
T
Site 42
S317
A
S
T
P
V
L
K
S
S
T
P
T
P
R
S
Site 43
S318
S
T
P
V
L
K
S
S
T
P
T
P
R
S
D
Site 44
T319
T
P
V
L
K
S
S
T
P
T
P
R
S
D
M
Site 45
T321
V
L
K
S
S
T
P
T
P
R
S
D
M
P
T
Site 46
S324
S
S
T
P
T
P
R
S
D
M
P
T
P
G
T
Site 47
T328
T
P
R
S
D
M
P
T
P
G
T
S
A
T
P
Site 48
T331
S
D
M
P
T
P
G
T
S
A
T
P
G
L
R
Site 49
S332
D
M
P
T
P
G
T
S
A
T
P
G
L
R
P
Site 50
T334
P
T
P
G
T
S
A
T
P
G
L
R
P
G
L
Site 51
T385
A
G
M
N
G
E
L
T
S
P
G
A
A
Y
A
Site 52
S386
G
M
N
G
E
L
T
S
P
G
A
A
Y
A
S
Site 53
S393
S
P
G
A
A
Y
A
S
L
H
N
M
S
P
Q
Site 54
S398
Y
A
S
L
H
N
M
S
P
Q
M
S
A
A
A
Site 55
T431
P
P
H
M
R
V
P
T
I
P
P
N
L
A
G
Site 56
Y446
I
P
G
G
K
P
A
Y
S
F
H
V
T
A
D
Site 57
S447
P
G
G
K
P
A
Y
S
F
H
V
T
A
D
G
Site 58
T451
P
A
Y
S
F
H
V
T
A
D
G
Q
M
Q
P
Site 59
Y500
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Site 60
S519
I
S
H
P
G
N
K
S
P
V
S
Q
L
D
C
Site 61
S522
P
G
N
K
S
P
V
S
Q
L
D
C
L
N
R
Site 62
Y532
D
C
L
N
R
D
N
Y
I
R
S
C
K
L
L
Site 63
T571
P
R
I
K
A
E
L
T
S
S
A
P
A
C
Y
Site 64
Y578
T
S
S
A
P
A
C
Y
A
L
A
I
S
P
D
Site 65
S583
A
C
Y
A
L
A
I
S
P
D
S
K
V
C
F
Site 66
S620
Q
G
H
T
D
G
A
S
C
I
D
I
S
N
D
Site 67
T629
I
D
I
S
N
D
G
T
K
L
W
T
G
G
L
Site 68
T639
W
T
G
G
L
D
N
T
V
R
S
W
D
L
R
Site 69
T657
Q
L
Q
Q
H
D
F
T
S
Q
I
F
S
L
G
Site 70
S658
L
Q
Q
H
D
F
T
S
Q
I
F
S
L
G
Y
Site 71
Y692
H
V
N
K
P
D
K
Y
Q
L
H
L
H
E
S
Site 72
S699
Y
Q
L
H
L
H
E
S
C
V
L
S
L
K
F
Site 73
S703
L
H
E
S
C
V
L
S
L
K
F
A
Y
C
G
Site 74
T727
N
L
L
N
A
W
R
T
P
Y
G
A
S
I
F
Site 75
Y729
L
N
A
W
R
T
P
Y
G
A
S
I
F
Q
S
Site 76
S732
W
R
T
P
Y
G
A
S
I
F
Q
S
K
E
S
Site 77
S736
Y
G
A
S
I
F
Q
S
K
E
S
S
S
V
L
Site 78
S739
S
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
Site 79
S740
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
Site 80
S741
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
S
Site 81
S744
K
E
S
S
S
V
L
S
C
D
I
S
V
D
D
Site 82
Y753
D
I
S
V
D
D
K
Y
I
V
T
G
S
G
D
Site 83
S758
D
K
Y
I
V
T
G
S
G
D
K
K
A
T
V
Site 84
T764
G
S
G
D
K
K
A
T
V
Y
E
V
I
Y
_
Site 85
Y766
G
D
K
K
A
T
V
Y
E
V
I
Y
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation