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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLE2
Full Name:
Transducin-like enhancer protein 2
Alias:
Enhancer of split groucho 2; ESG; ESG2; FLJ41188; GRG2; Transducin-like enhancer of split 2
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
79841
Number AA:
743
UniProt ID:
Q04725
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0009887
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
Y
P
Q
G
R
H
P
T
P
L
Q
S
G
Q
P
Site 2
S13
R
H
P
T
P
L
Q
S
G
Q
P
F
K
F
S
Site 3
S51
L
E
C
E
K
L
A
S
E
K
T
E
M
Q
R
Site 4
T54
E
K
L
A
S
E
K
T
E
M
Q
R
H
Y
V
Site 5
Y60
K
T
E
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Site 6
Y63
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
Site 7
Y64
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
N
Site 8
T114
V
E
R
A
K
Q
V
T
V
G
E
L
N
S
L
Site 9
S130
G
Q
Q
L
Q
P
L
S
H
H
A
P
P
V
P
Site 10
S182
A
G
V
E
A
E
G
S
R
V
E
R
A
P
S
Site 11
S189
S
R
V
E
R
A
P
S
R
S
A
S
P
S
P
Site 12
S191
V
E
R
A
P
S
R
S
A
S
P
S
P
P
E
Site 13
S193
R
A
P
S
R
S
A
S
P
S
P
P
E
S
L
Site 14
S195
P
S
R
S
A
S
P
S
P
P
E
S
L
V
E
Site 15
S199
A
S
P
S
P
P
E
S
L
V
E
E
E
R
P
Site 16
S207
L
V
E
E
E
R
P
S
G
P
G
G
G
G
K
Site 17
S223
R
A
D
E
K
E
P
S
G
P
Y
E
S
D
E
Site 18
S228
E
P
S
G
P
Y
E
S
D
E
D
K
S
D
Y
Site 19
S233
Y
E
S
D
E
D
K
S
D
Y
N
L
V
V
D
Site 20
Y235
S
D
E
D
K
S
D
Y
N
L
V
V
D
E
D
Site 21
S245
V
V
D
E
D
Q
P
S
E
P
P
S
P
A
T
Site 22
S249
D
Q
P
S
E
P
P
S
P
A
T
T
P
C
G
Site 23
T252
S
E
P
P
S
P
A
T
T
P
C
G
K
V
P
Site 24
T253
E
P
P
S
P
A
T
T
P
C
G
K
V
P
I
Site 25
S271
A
R
R
D
L
V
D
S
P
A
S
L
A
S
S
Site 26
S277
D
S
P
A
S
L
A
S
S
L
G
S
P
L
P
Site 27
S278
S
P
A
S
L
A
S
S
L
G
S
P
L
P
R
Site 28
S281
S
L
A
S
S
L
G
S
P
L
P
R
A
K
E
Site 29
S297
I
L
N
D
L
P
A
S
T
P
A
S
K
S
C
Site 30
T298
L
N
D
L
P
A
S
T
P
A
S
K
S
C
D
Site 31
S301
L
P
A
S
T
P
A
S
K
S
C
D
S
S
P
Site 32
S303
A
S
T
P
A
S
K
S
C
D
S
S
P
P
Q
Site 33
S306
P
A
S
K
S
C
D
S
S
P
P
Q
D
A
S
Site 34
S307
A
S
K
S
C
D
S
S
P
P
Q
D
A
S
T
Site 35
S313
S
S
P
P
Q
D
A
S
T
P
G
P
S
S
A
Site 36
T314
S
P
P
Q
D
A
S
T
P
G
P
S
S
A
S
Site 37
S318
D
A
S
T
P
G
P
S
S
A
S
H
L
C
Q
Site 38
S319
A
S
T
P
G
P
S
S
A
S
H
L
C
Q
L
Site 39
S333
L
A
A
K
P
A
P
S
T
D
S
V
A
L
R
Site 40
T334
A
A
K
P
A
P
S
T
D
S
V
A
L
R
S
Site 41
S336
K
P
A
P
S
T
D
S
V
A
L
R
S
P
L
Site 42
S341
T
D
S
V
A
L
R
S
P
L
T
L
S
S
P
Site 43
S347
R
S
P
L
T
L
S
S
P
F
T
T
S
F
S
Site 44
T351
T
L
S
S
P
F
T
T
S
F
S
L
G
S
H
Site 45
S352
L
S
S
P
F
T
T
S
F
S
L
G
S
H
S
Site 46
S354
S
P
F
T
T
S
F
S
L
G
S
H
S
T
L
Site 47
S357
T
T
S
F
S
L
G
S
H
S
T
L
N
G
D
Site 48
S359
S
F
S
L
G
S
H
S
T
L
N
G
D
L
S
Site 49
T360
F
S
L
G
S
H
S
T
L
N
G
D
L
S
V
Site 50
S366
S
T
L
N
G
D
L
S
V
P
S
S
Y
V
S
Site 51
S369
N
G
D
L
S
V
P
S
S
Y
V
S
L
H
L
Site 52
S381
L
H
L
S
P
Q
V
S
S
S
V
V
Y
G
R
Site 53
S383
L
S
P
Q
V
S
S
S
V
V
Y
G
R
S
P
Site 54
S396
S
P
V
M
A
F
E
S
H
P
H
L
R
G
S
Site 55
S403
S
H
P
H
L
R
G
S
S
V
S
S
S
L
P
Site 56
S404
H
P
H
L
R
G
S
S
V
S
S
S
L
P
S
Site 57
S406
H
L
R
G
S
S
V
S
S
S
L
P
S
I
P
Site 58
S407
L
R
G
S
S
V
S
S
S
L
P
S
I
P
G
Site 59
S408
R
G
S
S
V
S
S
S
L
P
S
I
P
G
G
Site 60
S411
S
V
S
S
S
L
P
S
I
P
G
G
K
P
A
Site 61
Y419
I
P
G
G
K
P
A
Y
S
F
H
V
S
A
D
Site 62
S420
P
G
G
K
P
A
Y
S
F
H
V
S
A
D
G
Site 63
S424
P
A
Y
S
F
H
V
S
A
D
G
Q
M
Q
P
Site 64
Y473
S
G
S
T
Q
H
V
Y
T
G
G
K
G
C
V
Site 65
T492
V
G
Q
P
G
A
K
T
P
V
A
Q
L
D
C
Site 66
Y505
D
C
L
N
R
D
N
Y
I
R
S
C
K
L
L
Site 67
T544
P
R
I
K
A
E
L
T
S
S
A
P
A
C
Y
Site 68
S593
Q
G
H
T
D
G
A
S
C
I
D
I
S
D
Y
Site 69
Y600
S
C
I
D
I
S
D
Y
G
T
R
L
W
T
G
Site 70
T602
I
D
I
S
D
Y
G
T
R
L
W
T
G
G
L
Site 71
T606
D
Y
G
T
R
L
W
T
G
G
L
D
N
T
V
Site 72
S630
Q
L
Q
Q
H
D
F
S
S
Q
I
F
S
L
G
Site 73
S631
L
Q
Q
H
D
F
S
S
Q
I
F
S
L
G
H
Site 74
S635
D
F
S
S
Q
I
F
S
L
G
H
C
P
N
Q
Site 75
Y665
H
V
R
K
P
E
K
Y
Q
L
H
L
H
E
S
Site 76
S672
Y
Q
L
H
L
H
E
S
C
V
L
S
L
K
F
Site 77
S676
L
H
E
S
C
V
L
S
L
K
F
A
S
C
G
Site 78
T689
C
G
R
W
F
V
S
T
G
K
D
N
L
L
N
Site 79
T700
N
L
L
N
A
W
R
T
P
Y
G
A
S
I
F
Site 80
Y702
L
N
A
W
R
T
P
Y
G
A
S
I
F
Q
S
Site 81
S705
W
R
T
P
Y
G
A
S
I
F
Q
S
K
E
S
Site 82
S709
Y
G
A
S
I
F
Q
S
K
E
S
S
S
V
L
Site 83
S712
S
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
Site 84
S713
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
Site 85
S714
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
S
Site 86
S717
K
E
S
S
S
V
L
S
C
D
I
S
R
N
N
Site 87
S721
S
V
L
S
C
D
I
S
R
N
N
K
Y
I
V
Site 88
Y726
D
I
S
R
N
N
K
Y
I
V
T
G
S
G
D
Site 89
S731
N
K
Y
I
V
T
G
S
G
D
K
K
A
T
V
Site 90
T737
G
S
G
D
K
K
A
T
V
Y
E
V
V
Y
_
Site 91
Y739
G
D
K
K
A
T
V
Y
E
V
V
Y
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation