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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HGFAC
Full Name:
Hepatocyte growth factor activator
Alias:
hepatocyte growth factor activator; HGF activator; HGFA; HGFAP
Type:
EC 3.4.21.-; Protease
Mass (Da):
70682
Number AA:
655
UniProt ID:
Q04756
International Prot ID:
IPI00029193
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
R
W
A
W
V
P
S
P
W
P
P
P
G
L
Site 2
T42
P
Q
P
G
G
N
R
T
E
S
P
E
P
N
A
Site 3
S44
P
G
G
N
R
T
E
S
P
E
P
N
A
T
A
Site 4
T50
E
S
P
E
P
N
A
T
A
T
P
A
I
P
T
Site 5
T67
V
T
S
V
T
S
E
T
P
A
T
S
A
P
E
Site 6
T70
V
T
S
E
T
P
A
T
S
A
P
E
A
E
G
Site 7
S80
P
E
A
E
G
P
Q
S
G
G
L
P
P
P
P
Site 8
S92
P
P
P
R
A
V
P
S
S
S
S
P
Q
A
Q
Site 9
S93
P
P
R
A
V
P
S
S
S
S
P
Q
A
Q
A
Site 10
S94
P
R
A
V
P
S
S
S
S
P
Q
A
Q
A
L
Site 11
S95
R
A
V
P
S
S
S
S
P
Q
A
Q
A
L
T
Site 12
T102
S
P
Q
A
Q
A
L
T
E
D
G
R
P
C
R
Site 13
Y114
P
C
R
F
P
F
R
Y
G
G
R
M
L
H
A
Site 14
T123
G
R
M
L
H
A
C
T
S
E
G
S
A
H
R
Site 15
S124
R
M
L
H
A
C
T
S
E
G
S
A
H
R
K
Site 16
T152
W
G
Y
C
V
E
A
T
P
P
P
G
G
P
A
Site 17
S176
C
L
N
G
G
S
C
S
N
T
Q
D
P
Q
S
Site 18
T178
N
G
G
S
C
S
N
T
Q
D
P
Q
S
Y
H
Site 19
Y184
N
T
Q
D
P
Q
S
Y
H
C
S
C
P
R
A
Site 20
T193
C
S
C
P
R
A
F
T
G
K
D
C
G
T
E
Site 21
Y208
K
C
F
D
E
T
R
Y
E
Y
L
E
G
G
D
Site 22
Y210
F
D
E
T
R
Y
E
Y
L
E
G
G
D
R
W
Site 23
T243
W
C
E
G
T
R
H
T
A
C
L
S
S
P
C
Site 24
S247
T
R
H
T
A
C
L
S
S
P
C
L
N
G
G
Site 25
S248
R
H
T
A
C
L
S
S
P
C
L
N
G
G
T
Site 26
S299
T
G
Y
R
G
V
A
S
T
S
A
S
G
L
S
Site 27
T300
G
Y
R
G
V
A
S
T
S
A
S
G
L
S
C
Site 28
S306
S
T
S
A
S
G
L
S
C
L
A
W
N
S
D
Site 29
Y316
A
W
N
S
D
L
L
Y
Q
E
L
H
V
D
S
Site 30
Y337
L
G
L
G
P
H
A
Y
C
R
N
P
D
N
D
Site 31
Y350
N
D
E
R
P
W
C
Y
V
V
K
D
S
A
L
Site 32
S369
C
R
L
E
A
C
E
S
L
T
R
V
Q
L
S
Site 33
S376
S
L
T
R
V
Q
L
S
P
D
L
L
A
T
L
Site 34
S388
A
T
L
P
E
P
A
S
P
G
R
Q
A
C
G
Site 35
T402
G
R
R
H
K
K
R
T
F
L
R
P
R
I
I
Site 36
S412
R
P
R
I
I
G
G
S
S
S
L
P
G
S
H
Site 37
S413
P
R
I
I
G
G
S
S
S
L
P
G
S
H
P
Site 38
S414
R
I
I
G
G
S
S
S
L
P
G
S
H
P
W
Site 39
S450
V
S
A
A
H
C
F
S
H
S
P
P
R
D
S
Site 40
S452
A
A
H
C
F
S
H
S
P
P
R
D
S
V
S
Site 41
S457
S
H
S
P
P
R
D
S
V
S
V
V
L
G
Q
Site 42
S459
S
P
P
R
D
S
V
S
V
V
L
G
Q
H
F
Site 43
T474
F
N
R
T
T
D
V
T
Q
T
F
G
I
E
K
Site 44
T476
R
T
T
D
V
T
Q
T
F
G
I
E
K
Y
I
Site 45
Y482
Q
T
F
G
I
E
K
Y
I
P
Y
T
L
Y
S
Site 46
Y485
G
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
Site 47
T486
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
Site 48
Y488
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
S
D
Site 49
T512
K
K
G
D
R
C
A
T
R
S
Q
F
V
Q
P
Site 50
S527
I
C
L
P
E
P
G
S
T
F
P
A
G
H
K
Site 51
T528
C
L
P
E
P
G
S
T
F
P
A
G
H
K
C
Site 52
S548
G
H
L
D
E
N
V
S
G
Y
S
S
S
L
R
Site 53
S552
E
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
Site 54
S553
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
P
Site 55
S569
V
A
D
H
K
C
S
S
P
E
V
Y
G
A
D
Site 56
Y573
K
C
S
S
P
E
V
Y
G
A
D
I
S
P
N
Site 57
Y586
P
N
M
L
C
A
G
Y
F
D
C
K
S
D
A
Site 58
S598
S
D
A
C
Q
G
D
S
G
G
P
L
A
C
E
Site 59
Y631
R
L
H
K
P
G
V
Y
T
R
V
A
N
Y
V
Site 60
Y637
V
Y
T
R
V
A
N
Y
V
D
W
I
N
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation