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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKCt
Full Name:
Protein kinase C theta type
Alias:
EC 2.7.11.13; Kinase PKC-theta; KPCT; NPKC-theta; PKCQ; PKC-theta; PRKCQ; PRKCT; Protein kinase C, theta; Protein kinase C, theta type
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13;
AGC
group; PKC family; Delta subfamily
Mass (Da):
81865
Number AA:
706
UniProt ID:
Q04759
International Prot ID:
IPI00029196
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006509
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-serine kinase C theta S695 phosphosite-specific antibody AB-PK772#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK772#Protein-serine kinase C theta Y545 phosphosite-specific antibody AB-PK773#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK773#Protein-serine kinase C theta (T542-P548, human) pY545 phosphopeptide - Powder PE-04ADG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADG99#Protein-serine kinase C theta (R692-N698, human) pS695 phosphopeptide - Powder PE-04AOX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOX99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y36
C
A
V
L
V
K
E
Y
V
E
S
E
N
G
Q
Site 2
Y45
E
S
E
N
G
Q
M
Y
I
Q
K
K
P
T
M
Site 3
T51
M
Y
I
Q
K
K
P
T
M
Y
P
P
W
D
S
Site 4
Y53
I
Q
K
K
P
T
M
Y
P
P
W
D
S
T
F
Site 5
S83
G
K
N
V
D
L
I
S
E
T
T
V
E
L
Y
Site 6
Y90
S
E
T
T
V
E
L
Y
S
L
A
E
R
C
R
Site 7
Y121
R
M
L
M
N
A
R
Y
F
L
E
M
S
D
T
Site 8
S126
A
R
Y
F
L
E
M
S
D
T
K
D
M
N
E
Site 9
T165
K
C
H
E
F
T
A
T
F
F
P
Q
P
T
F
Site 10
Y188
W
G
L
N
K
Q
G
Y
Q
C
R
Q
C
N
A
Site 11
S212
V
I
A
K
C
T
G
S
A
I
N
S
R
E
T
Site 12
T219
S
A
I
N
S
R
E
T
M
F
H
K
E
R
F
Site 13
Y237
M
P
H
R
F
K
V
Y
N
Y
K
S
P
T
F
Site 14
Y239
H
R
F
K
V
Y
N
Y
K
S
P
T
F
C
E
Site 15
T298
A
L
A
M
I
E
S
T
Q
Q
A
R
C
L
R
Site 16
T307
Q
A
R
C
L
R
D
T
E
Q
I
F
R
E
G
Site 17
S323
V
E
I
G
L
P
C
S
I
K
N
E
A
R
P
Site 18
T335
A
R
P
P
C
L
P
T
P
G
K
R
E
P
Q
Site 19
S345
K
R
E
P
Q
G
I
S
W
E
S
P
L
D
E
Site 20
S348
P
Q
G
I
S
W
E
S
P
L
D
E
V
D
K
Site 21
S370
E
L
N
K
E
R
P
S
L
Q
I
K
L
K
I
Site 22
T402
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
Site 23
S433
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
Site 24
Y468
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
Site 25
S479
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
Site 26
T482
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
Site 27
T536
N
M
L
G
D
A
K
T
N
T
F
C
G
T
P
Site 28
T538
L
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
Site 29
T542
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
Site 30
Y545
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
Protein-serine kinase C theta Y545 phosphosite-specific antibody AB-PK773#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK773#Protein-serine kinase C theta (T542-P548, human) pY545 phosphopeptide - Powder PE-04ADG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADG99
Site 31
Y556
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
Site 32
S577
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
Site 33
S590
D
E
E
E
L
F
H
S
I
R
M
D
N
P
F
Site 34
Y598
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
Site 35
S657
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
Site 36
S662
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
Site 37
S676
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
Site 38
S685
A
D
R
A
L
I
N
S
M
D
Q
N
M
F
R
Site 39
S695
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
Protein-serine kinase C theta S695 phosphosite-specific antibody AB-PK772#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK772#Protein-serine kinase C theta (R692-N698, human) pS695 phosphopeptide - Powder PE-04AOX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOX99
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation