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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALK2
Full Name:
Activin receptor type-1
Alias:
ACVR1; ACVRLK2; ALK-2; EC 2.7.11.30; Serine,threonine-protein kinase receptor R1; SKR1; TSR-I
Type:
Protein-serine kinase, TKL group, STKR family, Type 1 subfamily
Mass (Da):
57153
Number AA:
509
UniProt ID:
Q04771
International Prot ID:
IPI00029219
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048179
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046332
GO:0048185
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0000082
GO:0032926
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
M
I
A
L
P
S
P
S
M
E
D
E
K
P
K
Site 2
Y164
L
N
P
R
D
V
E
Y
G
T
I
E
G
L
I
Site 3
T179
T
T
N
V
G
D
S
T
L
A
D
L
L
D
H
Site 4
S187
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
Site 5
T189
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
Site 6
S190
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
Site 7
S192
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
Site 8
Y219
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
Site 9
S226
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
Site 10
S238
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
Site 11
S239
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
Site 12
S244
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Site 13
Y252
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
Site 14
T254
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
Site 15
S268
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
Site 16
T271
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
Site 17
S272
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
Site 18
S275
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
Site 19
S276
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
Site 20
Y285
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
Site 21
Y292
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
Site 22
Y294
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
Site 23
S339
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
Site 24
S362
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
Site 25
T378
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
Site 26
Y381
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
Site 27
T390
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
Site 28
Y399
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
Site 29
S420
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
Site 30
Y427
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
Site 31
Y432
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
Site 32
S440
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
Site 33
S463
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
Site 34
T466
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
Site 35
S469
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
Site 36
Y479
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
Site 37
T487
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
Site 38
T494
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
Site 39
T496
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
Site 40
S501
T
L
T
K
I
D
N
S
L
D
K
L
K
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation