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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1C1
Full Name:
Aldo-keto reductase family 1 member C1
Alias:
20 alpha-hydroxysteroid dehydrogenase; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); 2-ALPHA-HSD; AK1C1; Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; Chlordecone reductase homolog HAKRC; DD1; DDH; DDH1; DHB5; Dihydrodiol dehydrogenase 1/2; EC 1.1.1.-; EC 1.1.1.149; EC 1.3.1.20; HAKRC; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MBAB; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Type:
Oxidoreductase; EC 1.3.1.20; EC 1.1.1.-; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.149
Mass (Da):
36788
Number AA:
323
UniProt ID:
Q04828
International Prot ID:
IPI00029733
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0047006
GO:0047042
GO:0004033
PhosphoSite+
KinaseNET
Biological Process:
GO:0015721
GO:0008206
GO:0042632
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y5
_
_
_
M
D
S
K
Y
Q
C
V
K
L
N
D
Site 2
T23
M
P
V
L
G
F
G
T
Y
A
P
A
E
V
P
Site 3
Y24
P
V
L
G
F
G
T
Y
A
P
A
E
V
P
K
Site 4
S32
A
P
A
E
V
P
K
S
K
A
L
E
A
T
K
Site 5
T38
K
S
K
A
L
E
A
T
K
L
A
I
E
A
G
Site 6
Y55
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
Site 7
S67
Q
V
G
L
A
I
R
S
K
I
A
D
G
S
V
Site 8
S73
R
S
K
I
A
D
G
S
V
K
R
E
D
I
F
Site 9
Y81
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
Site 10
T82
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
Site 11
S89
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
Site 12
Y110
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
Site 13
S162
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
Site 14
S166
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
Site 15
Y184
L
N
K
P
G
L
K
Y
K
P
V
C
N
Q
V
Site 16
Y196
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
Site 17
S208
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Site 18
S221
V
A
Y
S
A
L
G
S
H
R
E
E
P
W
V
Site 19
S232
E
P
W
V
D
P
N
S
P
V
L
L
E
D
P
Site 20
T251
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Site 21
S271
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Site 22
Y272
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
Site 23
T289
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
Site 24
Y305
G
L
N
R
N
V
R
Y
L
T
L
D
I
F
A
Site 25
T307
N
R
N
V
R
Y
L
T
L
D
I
F
A
G
P
Site 26
Y317
I
F
A
G
P
P
N
Y
P
F
S
D
E
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation