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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
YWHAH
Full Name:
14-3-3 protein eta
Alias:
1433F; 143F; KCIP-1; Protein AS1; Protein kinase C inhibitor protein-1; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1
Type:
Nuclear receptor co-regulator; Adaptor/scaffold
Mass (Da):
28219
Number AA:
246
UniProt ID:
Q04917
International Prot ID:
IPI00216319
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005102
GO:0005159
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0006706
GO:0006713
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
A
E
Q
A
E
R
Y
D
D
M
A
S
A
M
Site 2
S25
E
R
Y
D
D
M
A
S
A
M
K
A
V
T
E
Site 3
S38
T
E
L
N
E
P
L
S
N
E
D
R
N
L
L
Site 4
S46
N
E
D
R
N
L
L
S
V
A
Y
K
N
V
V
Site 5
Y49
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
Site 6
S58
N
V
V
G
A
R
R
S
S
W
R
V
I
S
S
Site 7
S59
V
V
G
A
R
R
S
S
W
R
V
I
S
S
I
Site 8
S64
R
S
S
W
R
V
I
S
S
I
E
Q
K
T
M
Site 9
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
M
A
Site 10
Y85
K
L
E
K
V
K
A
Y
R
E
K
I
E
K
E
Site 11
T95
K
I
E
K
E
L
E
T
V
C
N
D
V
L
S
Site 12
Y117
K
N
C
N
D
F
Q
Y
E
S
K
V
F
Y
L
Site 13
Y123
Q
Y
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Site 14
Y130
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
Site 15
Y131
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
Site 16
Y133
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
S
G
Site 17
S139
R
Y
L
A
E
V
A
S
G
E
K
K
N
S
V
Site 18
S145
A
S
G
E
K
K
N
S
V
V
E
A
S
E
A
Site 19
Y154
V
E
A
S
E
A
A
Y
K
E
A
F
E
I
S
Site 20
S161
Y
K
E
A
F
E
I
S
K
E
Q
M
Q
P
T
Site 21
T168
S
K
E
Q
M
Q
P
T
H
P
I
R
L
G
L
Site 22
Y184
L
N
F
S
V
F
Y
Y
E
I
Q
N
A
P
E
Site 23
T210
D
A
I
A
E
L
D
T
L
N
E
D
S
Y
K
Site 24
S215
L
D
T
L
N
E
D
S
Y
K
D
S
T
L
I
Site 25
Y216
D
T
L
N
E
D
S
Y
K
D
S
T
L
I
M
Site 26
S219
N
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
Site 27
T220
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
Site 28
T231
Q
L
L
R
D
N
L
T
L
W
T
S
D
Q
Q
Site 29
T234
R
D
N
L
T
L
W
T
S
D
Q
Q
D
E
E
Site 30
S235
D
N
L
T
L
W
T
S
D
Q
Q
D
E
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation