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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CSTF1
Full Name:
Cleavage stimulation factor subunit 1
Alias:
CF-1 50 kDa subunit; Cleavage stimulation factor, 50 kDa subunit; CSTF 50 kDa subunit; CSTF-50
Type:
RNA binding protein
Mass (Da):
48358
Number AA:
431
UniProt ID:
Q05048
International Prot ID:
IPI00011528
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
L
K
D
R
Q
Q
L
Y
K
L
I
I
S
Q
L
Site 2
Y24
L
I
I
S
Q
L
L
Y
D
G
Y
I
S
I
A
Site 3
S42
I
N
E
I
K
P
Q
S
V
C
A
P
S
E
Q
Site 4
T63
L
G
M
E
N
D
D
T
A
V
Q
Y
A
I
G
Site 5
Y67
N
D
D
T
A
V
Q
Y
A
I
G
R
S
D
T
Site 6
T91
E
F
D
A
D
V
Q
T
M
S
P
E
A
S
E
Site 7
S93
D
A
D
V
Q
T
M
S
P
E
A
S
E
Y
E
Site 8
S97
Q
T
M
S
P
E
A
S
E
Y
E
T
C
Y
V
Site 9
Y99
M
S
P
E
A
S
E
Y
E
T
C
Y
V
T
S
Site 10
T101
P
E
A
S
E
Y
E
T
C
Y
V
T
S
H
K
Site 11
Y103
A
S
E
Y
E
T
C
Y
V
T
S
H
K
G
P
Site 12
T115
K
G
P
C
R
V
A
T
Y
S
R
D
G
Q
L
Site 13
Y116
G
P
C
R
V
A
T
Y
S
R
D
G
Q
L
I
Site 14
S117
P
C
R
V
A
T
Y
S
R
D
G
Q
L
I
A
Site 15
S131
A
T
G
S
A
D
A
S
I
K
I
L
D
T
E
Site 16
T137
A
S
I
K
I
L
D
T
E
R
M
L
A
K
S
Site 17
Y170
H
P
V
I
R
T
L
Y
D
H
V
D
E
V
T
Site 18
S192
E
Q
I
L
A
S
G
S
R
D
Y
T
L
K
L
Site 19
Y195
L
A
S
G
S
R
D
Y
T
L
K
L
F
D
Y
Site 20
T196
A
S
G
S
R
D
Y
T
L
K
L
F
D
Y
S
Site 21
Y202
Y
T
L
K
L
F
D
Y
S
K
P
S
A
K
R
Site 22
S206
L
F
D
Y
S
K
P
S
A
K
R
A
F
K
Y
Site 23
Y213
S
A
K
R
A
F
K
Y
I
Q
E
A
E
M
L
Site 24
S222
Q
E
A
E
M
L
R
S
I
S
F
H
P
S
G
Site 25
S224
A
E
M
L
R
S
I
S
F
H
P
S
G
D
F
Site 26
T240
L
V
G
T
Q
H
P
T
L
R
L
Y
D
I
N
Site 27
Y244
Q
H
P
T
L
R
L
Y
D
I
N
T
F
Q
C
Site 28
Y270
D
A
I
C
S
V
N
Y
N
S
S
A
N
M
Y
Site 29
Y277
Y
N
S
S
A
N
M
Y
V
T
G
S
K
D
G
Site 30
T279
S
S
A
N
M
Y
V
T
G
S
K
D
G
C
I
Site 31
T298
G
V
S
N
R
C
I
T
T
F
E
K
A
H
D
Site 32
T299
V
S
N
R
C
I
T
T
F
E
K
A
H
D
G
Site 33
S318
S
A
I
F
S
K
N
S
K
Y
I
L
S
S
G
Site 34
Y320
I
F
S
K
N
S
K
Y
I
L
S
S
G
K
D
Site 35
S323
K
N
S
K
Y
I
L
S
S
G
K
D
S
V
A
Site 36
S324
N
S
K
Y
I
L
S
S
G
K
D
S
V
A
K
Site 37
T337
A
K
L
W
E
I
S
T
G
R
T
L
V
R
Y
Site 38
T340
W
E
I
S
T
G
R
T
L
V
R
Y
T
G
A
Site 39
Y344
T
G
R
T
L
V
R
Y
T
G
A
G
L
S
G
Site 40
T345
G
R
T
L
V
R
Y
T
G
A
G
L
S
G
R
Site 41
S350
R
Y
T
G
A
G
L
S
G
R
Q
V
H
R
T
Site 42
T357
S
G
R
Q
V
H
R
T
Q
A
V
F
N
H
T
Site 43
Y367
V
F
N
H
T
E
D
Y
V
L
L
P
D
E
R
Site 44
S377
L
P
D
E
R
T
I
S
L
C
C
W
D
S
R
Site 45
T385
L
C
C
W
D
S
R
T
A
E
R
R
N
L
L
Site 46
S393
A
E
R
R
N
L
L
S
L
G
H
N
N
I
V
Site 47
Y425
D
F
R
A
R
F
W
Y
R
R
S
T
T
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation