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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBE3A
Full Name:
Ubiquitin-protein ligase E3A
Alias:
ANCR; Angelman syndrome; AS; CTCL tumor antigen se37-2; E6AP; E6-AP; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HPVE6A; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Ubiquitin protein ligase E3A
Type:
EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
100646
Number AA:
875
UniProt ID:
Q05086
International Prot ID:
IPI00219197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0000502
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0044419
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
E
K
L
H
Q
C
Y
W
K
S
G
E
P
Q
Site 2
S16
W
K
S
G
E
P
Q
S
D
D
I
E
A
S
R
Site 3
Y37
K
H
L
I
E
R
Y
Y
H
Q
L
T
E
G
C
Site 4
S88
K
L
C
D
P
H
P
S
K
K
G
A
S
S
A
Site 5
S94
P
S
K
K
G
A
S
S
A
Y
L
E
N
S
K
Site 6
Y96
K
K
G
A
S
S
A
Y
L
E
N
S
K
G
A
Site 7
S100
S
S
A
Y
L
E
N
S
K
G
A
P
N
N
S
Site 8
S107
S
K
G
A
P
N
N
S
C
S
E
I
K
M
N
Site 9
S109
G
A
P
N
N
S
C
S
E
I
K
M
N
K
K
Site 10
T126
R
I
D
F
K
D
V
T
Y
L
T
E
E
K
V
Site 11
Y127
I
D
F
K
D
V
T
Y
L
T
E
E
K
V
Y
Site 12
Y134
Y
L
T
E
E
K
V
Y
E
I
L
E
L
C
R
Site 13
Y146
L
C
R
E
R
E
D
Y
S
P
L
I
R
V
I
Site 14
S147
C
R
E
R
E
D
Y
S
P
L
I
R
V
I
G
Site 15
S166
S
A
E
A
L
V
Q
S
F
R
K
V
K
Q
H
Site 16
S180
H
T
K
E
E
L
K
S
L
Q
A
K
D
E
D
Site 17
S207
A
A
A
M
E
E
D
S
E
A
S
S
S
R
I
Site 18
S211
E
E
D
S
E
A
S
S
S
R
I
G
D
S
S
Site 19
S212
E
D
S
E
A
S
S
S
R
I
G
D
S
S
Q
Site 20
S217
S
S
S
R
I
G
D
S
S
Q
G
D
N
N
L
Site 21
S218
S
S
R
I
G
D
S
S
Q
G
D
N
N
L
Q
Site 22
S233
K
L
G
P
D
D
V
S
V
D
I
D
A
I
R
Site 23
Y243
I
D
A
I
R
R
V
Y
T
R
L
L
S
N
E
Site 24
T244
D
A
I
R
R
V
Y
T
R
L
L
S
N
E
K
Site 25
S248
R
V
Y
T
R
L
L
S
N
E
K
I
E
T
A
Site 26
T272
P
N
V
E
C
D
L
T
Y
H
N
V
Y
S
R
Site 27
Y273
N
V
E
C
D
L
T
Y
H
N
V
Y
S
R
D
Site 28
Y277
D
L
T
Y
H
N
V
Y
S
R
D
P
N
Y
L
Site 29
S298
M
E
N
R
N
L
H
S
P
E
Y
L
E
M
A
Site 30
Y301
R
N
L
H
S
P
E
Y
L
E
M
A
L
P
L
Site 31
S329
G
K
L
I
R
L
W
S
K
Y
N
A
D
Q
I
Site 32
Y331
L
I
R
L
W
S
K
Y
N
A
D
Q
I
R
R
Site 33
Y349
T
F
Q
Q
L
I
T
Y
K
V
I
S
N
E
F
Site 34
S353
L
I
T
Y
K
V
I
S
N
E
F
N
S
R
N
Site 35
S404
D
E
E
P
I
P
E
S
S
E
L
T
L
Q
E
Site 36
T408
I
P
E
S
S
E
L
T
L
Q
E
L
L
G
E
Site 37
T436
E
T
E
L
G
V
K
T
L
D
C
R
K
P
L
Site 38
Y464
V
L
E
M
D
K
D
Y
T
F
F
K
V
E
T
Site 39
T465
L
E
M
D
K
D
Y
T
F
F
K
V
E
T
E
Site 40
T479
E
N
K
F
S
F
M
T
C
P
F
I
L
N
A
Site 41
Y494
V
T
K
N
L
G
L
Y
Y
D
N
R
I
R
M
Site 42
Y495
T
K
N
L
G
L
Y
Y
D
N
R
I
R
M
Y
Site 43
Y502
Y
D
N
R
I
R
M
Y
S
E
R
R
I
T
V
Site 44
S503
D
N
R
I
R
M
Y
S
E
R
R
I
T
V
L
Site 45
T508
M
Y
S
E
R
R
I
T
V
L
Y
S
L
V
Q
Site 46
Y511
E
R
R
I
T
V
L
Y
S
L
V
Q
G
Q
Q
Site 47
S512
R
R
I
T
V
L
Y
S
L
V
Q
G
Q
Q
L
Site 48
Y522
Q
G
Q
Q
L
N
P
Y
L
R
L
K
V
R
R
Site 49
Y556
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Site 50
T591
N
P
D
I
G
M
F
T
Y
D
E
S
T
K
L
Site 51
Y592
P
D
I
G
M
F
T
Y
D
E
S
T
K
L
F
Site 52
S605
L
F
W
F
N
P
S
S
F
E
T
E
G
Q
F
Site 53
T608
F
N
P
S
S
F
E
T
E
G
Q
F
T
L
I
Site 54
T647
K
L
M
G
K
K
G
T
F
R
D
L
G
D
S
Site 55
S654
T
F
R
D
L
G
D
S
H
P
V
L
Y
Q
S
Site 56
Y659
G
D
S
H
P
V
L
Y
Q
S
L
K
D
L
L
Site 57
S661
S
H
P
V
L
Y
Q
S
L
K
D
L
L
E
Y
Site 58
Y668
S
L
K
D
L
L
E
Y
E
G
N
V
E
D
D
Site 59
Y694
L
F
G
N
P
M
M
Y
D
L
K
E
N
G
D
Site 60
T706
N
G
D
K
I
P
I
T
N
E
N
R
K
E
F
Site 61
Y717
R
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
Site 62
S718
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
S
Site 63
Y720
F
V
N
L
Y
S
D
Y
I
L
N
K
S
V
E
Site 64
S725
S
D
Y
I
L
N
K
S
V
E
K
Q
F
K
A
Site 65
T741
R
R
G
F
H
M
V
T
N
E
S
P
L
K
Y
Site 66
S744
F
H
M
V
T
N
E
S
P
L
K
Y
L
F
R
Site 67
Y748
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Site 68
Y776
A
L
E
E
T
T
E
Y
D
G
G
Y
T
R
D
Site 69
Y780
T
T
E
Y
D
G
G
Y
T
R
D
S
V
L
I
Site 70
S784
D
G
G
Y
T
R
D
S
V
L
I
R
E
F
W
Site 71
T834
I
A
K
N
G
P
D
T
E
R
L
P
T
S
H
Site 72
T839
P
D
T
E
R
L
P
T
S
H
T
C
F
N
V
Site 73
S840
D
T
E
R
L
P
T
S
H
T
C
F
N
V
L
Site 74
Y852
N
V
L
L
L
P
E
Y
S
S
K
E
K
L
K
Site 75
S853
V
L
L
L
P
E
Y
S
S
K
E
K
L
K
E
Site 76
S854
L
L
L
P
E
Y
S
S
K
E
K
L
K
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation