KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DYN1
Full Name:
Dynamin-1
Alias:
B-dynamin; D100; DNM; DNM1; Dynamin 1; Dynamin BREDNM19; Dynamin, brain; EC 3.6.5.5
Type:
Hydrolase; EC 3.6.5.5; Motor protein; G protein; Vesicle protein
Mass (Da):
97408
Number AA:
864
UniProt ID:
Q05193
International Prot ID:
IPI00413140
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0003774
PhosphoSite+
KinaseNET
Biological Process:
GO:0006898
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
N
R
L
Q
D
A
F
S
A
I
G
Q
N
A
D
Site 2
S45
G
G
Q
S
A
G
K
S
S
V
L
E
N
F
V
Site 3
S61
R
D
F
L
P
R
G
S
G
I
V
T
R
R
P
Site 4
T65
P
R
G
S
G
I
V
T
R
R
P
L
V
L
Q
Site 5
Y80
L
V
N
A
T
T
E
Y
A
E
F
L
H
C
K
Site 6
T105
R
L
E
I
E
A
E
T
D
R
V
T
G
T
N
Site 7
T109
E
A
E
T
D
R
V
T
G
T
N
K
G
I
S
Site 8
S116
T
G
T
N
K
G
I
S
P
V
P
I
N
L
R
Site 9
Y125
V
P
I
N
L
R
V
Y
S
P
H
V
L
N
L
Site 10
S179
L
A
V
S
P
A
N
S
D
L
A
N
S
D
A
Site 11
T214
L
D
L
M
D
E
G
T
D
A
R
D
V
L
E
Site 12
Y231
L
L
P
L
R
R
G
Y
I
G
V
V
N
R
S
Site 13
S238
Y
I
G
V
V
N
R
S
Q
K
D
I
D
G
K
Site 14
S261
A
E
R
K
F
F
L
S
H
P
S
Y
R
H
L
Site 15
S264
K
F
F
L
S
H
P
S
Y
R
H
L
A
D
R
Site 16
Y265
F
F
L
S
H
P
S
Y
R
H
L
A
D
R
M
Site 17
T274
H
L
A
D
R
M
G
T
P
Y
L
Q
K
V
L
Site 18
Y276
A
D
R
M
G
T
P
Y
L
Q
K
V
L
N
Q
Site 19
T286
K
V
L
N
Q
Q
L
T
N
H
I
R
D
T
L
Site 20
T292
L
T
N
H
I
R
D
T
L
P
G
L
R
N
K
Site 21
S302
G
L
R
N
K
L
Q
S
Q
L
L
S
I
E
K
Site 22
S306
K
L
Q
S
Q
L
L
S
I
E
K
E
V
E
E
Site 23
Y314
I
E
K
E
V
E
E
Y
K
N
F
R
P
D
D
Site 24
T326
P
D
D
P
A
R
K
T
K
A
L
L
Q
M
V
Site 25
S347
F
E
K
R
I
E
G
S
G
D
Q
I
D
T
Y
Site 26
T353
G
S
G
D
Q
I
D
T
Y
E
L
S
G
G
A
Site 27
Y354
S
G
D
Q
I
D
T
Y
E
L
S
G
G
A
R
Site 28
S357
Q
I
D
T
Y
E
L
S
G
G
A
R
I
N
R
Site 29
S389
K
E
L
R
R
E
I
S
Y
A
I
K
N
I
H
Site 30
Y390
E
L
R
R
E
I
S
Y
A
I
K
N
I
H
G
Site 31
T411
T
P
D
M
A
F
E
T
I
V
K
K
Q
V
K
Site 32
S437
M
V
I
S
E
L
I
S
T
V
R
Q
C
T
K
Site 33
T438
V
I
S
E
L
I
S
T
V
R
Q
C
T
K
K
Site 34
T443
I
S
T
V
R
Q
C
T
K
K
L
Q
Q
Y
P
Site 35
Y449
C
T
K
K
L
Q
Q
Y
P
R
L
R
E
E
M
Site 36
T461
E
E
M
E
R
I
V
T
T
H
I
R
E
R
E
Site 37
Y485
L
I
D
I
E
L
A
Y
M
N
T
N
H
E
D
Site 38
S512
Q
M
N
K
K
K
T
S
G
N
Q
D
E
I
L
Site 39
Y563
D
E
E
K
E
K
K
Y
M
L
S
V
D
N
L
Site 40
S566
K
E
K
K
Y
M
L
S
V
D
N
L
K
L
R
Site 41
Y597
N
T
E
Q
R
N
V
Y
K
D
Y
R
Q
L
E
Site 42
Y600
Q
R
N
V
Y
K
D
Y
R
Q
L
E
L
A
C
Site 43
S615
E
T
Q
E
E
V
D
S
W
K
A
S
F
L
R
Site 44
S619
E
V
D
S
W
K
A
S
F
L
R
A
G
V
Y
Site 45
Y626
S
F
L
R
A
G
V
Y
P
E
R
V
G
D
K
Site 46
S637
V
G
D
K
E
K
A
S
E
T
E
E
N
G
S
Site 47
S644
S
E
T
E
E
N
G
S
D
S
F
M
H
S
M
Site 48
S646
T
E
E
N
G
S
D
S
F
M
H
S
M
D
P
Site 49
S650
G
S
D
S
F
M
H
S
M
D
P
Q
L
E
R
Site 50
T676
Y
M
A
I
V
N
K
T
V
R
D
L
M
P
K
Site 51
Y706
S
E
L
L
A
N
L
Y
S
C
G
D
Q
N
T
Site 52
S707
E
L
L
A
N
L
Y
S
C
G
D
Q
N
T
L
Site 53
T713
Y
S
C
G
D
Q
N
T
L
M
E
E
S
A
E
Site 54
Y732
R
D
E
M
L
R
M
Y
H
A
L
K
E
A
L
Site 55
T749
I
G
D
I
N
T
T
T
V
S
T
P
M
P
P
Site 56
S751
D
I
N
T
T
T
V
S
T
P
M
P
P
P
V
Site 57
T752
I
N
T
T
T
V
S
T
P
M
P
P
P
V
D
Site 58
S761
M
P
P
P
V
D
D
S
W
L
Q
V
Q
S
V
Site 59
S767
D
S
W
L
Q
V
Q
S
V
P
A
G
R
R
S
Site 60
S774
S
V
P
A
G
R
R
S
P
T
S
S
P
T
P
Site 61
T776
P
A
G
R
R
S
P
T
S
S
P
T
P
Q
R
Site 62
S777
A
G
R
R
S
P
T
S
S
P
T
P
Q
R
R
Site 63
S778
G
R
R
S
P
T
S
S
P
T
P
Q
R
R
A
Site 64
T780
R
S
P
T
S
S
P
T
P
Q
R
R
A
P
A
Site 65
S795
V
P
P
A
R
P
G
S
R
G
P
A
P
G
P
Site 66
S807
P
G
P
P
P
A
G
S
A
L
G
G
A
P
P
Site 67
S817
G
G
A
P
P
V
P
S
R
P
G
A
S
P
D
Site 68
S822
V
P
S
R
P
G
A
S
P
D
P
F
G
P
P
Site 69
S834
G
P
P
P
Q
V
P
S
R
P
N
R
A
P
P
Site 70
S845
R
A
P
P
G
V
P
S
R
S
G
Q
A
S
P
Site 71
S847
P
P
G
V
P
S
R
S
G
Q
A
S
P
S
R
Site 72
S851
P
S
R
S
G
Q
A
S
P
S
R
P
E
S
P
Site 73
S853
R
S
G
Q
A
S
P
S
R
P
E
S
P
R
P
Site 74
S857
A
S
P
S
R
P
E
S
P
R
P
P
F
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation