PhosphoNET

           
Protein Info 
   
Short Name:  Mad1
Full Name:  Max dimerization protein 1
Alias:  MAD; MAD1; MAX dimerization protein 1; MAX dimerizer; MAX-binding protein
Type:  Transcription, coactivator/corepressor
Mass (Da):  25254
Number AA:  221
UniProt ID:  Q05195
International Prot ID:  IPI00012034
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0003714  GO:0003700   PhosphoSite+ KinaseNET
Biological Process:  GO:0008283  GO:0007275  GO:0045449 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y18MLLEAADYLERRERE
Site 2Y30EREAEHGYASMLPYN
Site 3Y36GYASMLPYNNKDRDA
Site 4S50ALKRRNKSKKNNSSS
Site 5S55NKSKKNNSSSRSTHN
Site 6S56KSKKNNSSSRSTHNE
Site 7S57SKKNNSSSRSTHNEM
Site 8S59KNNSSSRSTHNEMEK
Site 9T60NNSSSRSTHNEMEKN
Site 10S89LVPLGPESSRHTTLS
Site 11S90VPLGPESSRHTTLSL
Site 12T93GPESSRHTTLSLLTK
Site 13T94PESSRHTTLSLLTKA
Site 14S96SSRHTTLSLLTKAKL
Site 15S145IERIRMDSIGSTVSS
Site 16S148IRMDSIGSTVSSERS
Site 17T149RMDSIGSTVSSERSD
Site 18S151DSIGSTVSSERSDSD
Site 19S152SIGSTVSSERSDSDR
Site 20S155STVSSERSDSDREEI
Site 21S157VSSERSDSDREEIDV
Site 22S168EIDVDVESTDYLTGD
Site 23Y171VDVESTDYLTGDLDW
Site 24T173VESTDYLTGDLDWSS
Site 25S179LTGDLDWSSSSVSDS
Site 26S180TGDLDWSSSSVSDSD
Site 27S181GDLDWSSSSVSDSDE
Site 28S182DLDWSSSSVSDSDER
Site 29S184DWSSSSVSDSDERGS
Site 30S186SSSSVSDSDERGSMQ
Site 31S191SDSDERGSMQSLGSD
Site 32S194DERGSMQSLGSDEGY
Site 33S197GSMQSLGSDEGYSST
Site 34Y201SLGSDEGYSSTSIKR
Site 35S203GSDEGYSSTSIKRIK
Site 36S214KRIKLQDSHKACLGL
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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