KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PKCZ
Full Name:
Protein kinase C zeta type
Alias:
EC 2.7.11.13; Kinase PKC-zeta; KPCZ; NPKC-zeta; PKC2; PKC-zeta; PKMzeta; PRKCZ; Protein kinase C zeta; Protein kinase C, zeta; Protein kinase M zeta
Type:
EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor);
AGC
group; PKC family; Iota subfamily
Mass (Da):
67660
Number AA:
592
UniProt ID:
Q05513
International Prot ID:
IPI00013749
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005768
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0043560
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0007242
GO:0046627
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-serine kinase C zeta S262+Y263 phosphosite-specific antibody AB-PK774#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK774#Protein-serine kinase C zeta T410 phosphosite-specific antibody AB-PK775#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK775#CREB1 (123-135) KinSub - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95#PKCE/ZSubtide - PKCe (PRKCE) protein kinase substrate peptide - Powder PE-01BIT95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIT95#Protein-serine kinase C zeta (I258-L267, human) pS262+pY263 phosphopeptide - Powder PE-04ARQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARQ99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
T
G
P
K
M
E
G
S
G
G
R
V
R
L
K
Site 2
Y22
R
V
R
L
K
A
H
Y
G
G
D
I
F
I
T
Site 3
T36
T
S
V
D
A
A
T
T
F
E
E
L
C
E
E
Site 4
T57
L
H
Q
Q
H
P
L
T
L
K
W
V
D
S
E
Site 5
S63
L
T
L
K
W
V
D
S
E
G
D
P
C
T
V
Site 6
T69
D
S
E
G
D
P
C
T
V
S
S
Q
M
E
L
Site 7
S71
E
G
D
P
C
T
V
S
S
Q
M
E
L
E
E
Site 8
S72
G
D
P
C
T
V
S
S
Q
M
E
L
E
E
A
Site 9
T99
I
I
H
V
F
P
S
T
P
E
Q
P
G
L
P
Site 10
S113
P
C
P
G
E
D
K
S
I
Y
R
R
G
A
R
Site 11
Y115
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Site 12
Y126
A
R
R
W
R
K
L
Y
R
A
N
G
H
L
F
Site 13
Y143
K
R
F
N
R
R
A
Y
C
G
Q
C
S
E
R
Site 14
S148
R
A
Y
C
G
Q
C
S
E
R
I
W
G
L
A
Site 15
Y159
W
G
L
A
R
Q
G
Y
R
C
I
N
C
K
L
Site 16
T179
C
H
G
L
V
P
L
T
C
R
K
H
M
D
S
Site 17
S186
T
C
R
K
H
M
D
S
V
M
P
S
Q
E
P
Site 18
S190
H
M
D
S
V
M
P
S
Q
E
P
P
V
D
D
Site 19
S206
N
E
D
A
D
L
P
S
E
E
T
D
G
I
A
Site 20
Y214
E
E
T
D
G
I
A
Y
I
S
S
S
R
K
H
Site 21
S216
T
D
G
I
A
Y
I
S
S
S
R
K
H
D
S
Site 22
S217
D
G
I
A
Y
I
S
S
S
R
K
H
D
S
I
Site 23
S218
G
I
A
Y
I
S
S
S
R
K
H
D
S
I
K
Site 24
S223
S
S
S
R
K
H
D
S
I
K
D
D
S
E
D
Site 25
S228
H
D
S
I
K
D
D
S
E
D
L
K
P
V
I
Site 26
S244
G
M
D
G
I
K
I
S
Q
G
L
G
L
Q
D
Site 27
S262
I
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
Protein-serine kinase C zeta S262+Y263 phosphosite-specific antibody AB-PK774#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK774#Protein-serine kinase C zeta (I258-L267, human) pS262+pY263 phosphopeptide - Powder PE-04ARQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARQ99
Site 28
Y263
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
Protein-serine kinase C zeta S262+Y263 phosphosite-specific antibody AB-PK774#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK774#Protein-serine kinase C zeta (I258-L267, human) pS262+pY263 phosphopeptide - Powder PE-04ARQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARQ99
Site 29
Y278
L
K
K
N
D
Q
I
Y
A
M
K
V
V
K
K
Site 30
S308
K
H
V
F
E
Q
A
S
S
N
P
F
L
V
G
Site 31
Y332
R
L
F
L
V
I
E
Y
V
N
G
G
D
L
M
Site 32
Y356
P
E
E
H
A
R
F
Y
A
A
E
I
C
I
A
Site 33
Y395
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
Site 34
T407
E
G
L
G
P
G
D
T
T
S
T
F
C
G
T
Site 35
T408
G
L
G
P
G
D
T
T
S
T
F
C
G
T
P
Site 36
S409
L
G
P
G
D
T
T
S
T
F
C
G
T
P
N
Site 37
T410
G
P
G
D
T
T
S
T
F
C
G
T
P
N
Y
Protein-serine kinase C zeta T410 phosphosite-specific antibody AB-PK775#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK775
Site 38
T414
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
Site 39
Y417
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
Site 40
Y428
E
I
L
R
G
E
E
Y
G
F
S
V
D
W
W
Site 41
T455
R
S
P
F
D
I
I
T
D
N
P
D
M
N
T
Site 42
Y465
P
D
M
N
T
E
D
Y
L
F
Q
V
I
L
E
Site 43
T507
R
L
G
C
R
P
Q
T
G
F
S
D
I
K
S
Site 44
S510
C
R
P
Q
T
G
F
S
D
I
K
S
H
A
F
Site 45
S514
T
G
F
S
D
I
K
S
H
A
F
F
R
S
I
Site 46
S520
K
S
H
A
F
F
R
S
I
D
W
D
L
L
E
Site 47
Y543
Q
P
Q
I
T
D
D
Y
G
L
D
N
F
D
T
Site 48
T550
Y
G
L
D
N
F
D
T
Q
F
T
S
E
P
V
Site 49
S554
N
F
D
T
Q
F
T
S
E
P
V
Q
L
T
P
Site 50
T560
T
S
E
P
V
Q
L
T
P
D
D
E
D
A
I
Site 51
S573
A
I
K
R
I
D
Q
S
E
F
E
G
F
E
Y
Site 52
S587
Y
I
N
P
L
L
L
S
T
E
E
S
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation