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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FPGS
Full Name:
Folylpolyglutamate synthase, mitochondrial
Alias:
EC 6.3.2.17; FOLC; Folylpoly-gamma-glutamate synthetase; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase
Type:
Enzyme, ligase - Metabolism of Cofactors and Vitamins group, Folate biosynthesis family
Mass (Da):
64609
Number AA:
587
UniProt ID:
Q05932
International Prot ID:
IPI00016745
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004326
PhosphoSite+
KinaseNET
Biological Process:
GO:0009396
GO:0006139
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
R
A
R
S
H
L
R
A
A
L
F
Site 2
T23
A
A
S
A
R
G
I
T
T
Q
V
A
A
R
R
Site 3
S33
V
A
A
R
R
G
L
S
A
W
P
V
P
Q
E
Site 4
T57
R
M
L
N
T
L
Q
T
N
A
G
Y
L
E
Q
Site 5
Y61
T
L
Q
T
N
A
G
Y
L
E
Q
V
K
R
Q
Site 6
T74
R
Q
R
G
D
P
Q
T
Q
L
E
A
M
E
L
Site 7
Y82
Q
L
E
A
M
E
L
Y
L
A
R
S
G
L
Q
Site 8
S109
T
G
T
K
G
K
G
S
T
C
A
F
T
E
C
Site 9
T114
K
G
S
T
C
A
F
T
E
C
I
L
R
S
Y
Site 10
T125
L
R
S
Y
G
L
K
T
G
F
F
S
S
P
H
Site 11
S148
R
I
N
G
Q
P
I
S
P
E
L
F
T
K
Y
Site 12
Y155
S
P
E
L
F
T
K
Y
F
W
R
L
Y
H
R
Site 13
Y160
T
K
Y
F
W
R
L
Y
H
R
L
E
E
T
K
Site 14
S170
L
E
E
T
K
D
G
S
C
V
S
M
P
P
Y
Site 15
S173
T
K
D
G
S
C
V
S
M
P
P
Y
F
R
F
Site 16
T235
H
T
S
L
L
G
D
T
V
E
K
I
A
W
Q
Site 17
S274
R
D
R
A
Q
Q
I
S
C
P
L
Y
L
C
P
Site 18
T294
E
E
G
G
P
P
L
T
L
G
L
E
G
E
H
Site 19
S304
L
E
G
E
H
Q
R
S
N
A
A
L
A
L
Q
Site 20
S331
G
A
G
E
P
K
A
S
R
P
G
L
L
W
Q
Site 21
S349
A
P
V
F
Q
P
T
S
H
M
R
L
G
L
R
Site 22
T358
M
R
L
G
L
R
N
T
E
W
P
G
R
T
Q
Site 23
T373
V
L
R
R
G
P
L
T
W
Y
L
D
G
A
H
Site 24
Y375
R
R
G
P
L
T
W
Y
L
D
G
A
H
T
A
Site 25
S403
L
Q
G
R
E
R
P
S
G
G
P
E
V
R
V
Site 26
T416
R
V
L
L
F
N
A
T
G
D
R
D
P
A
A
Site 27
S483
H
L
D
E
E
Q
A
S
P
D
L
W
S
A
P
Site 28
S488
Q
A
S
P
D
L
W
S
A
P
S
P
E
P
G
Site 29
S491
P
D
L
W
S
A
P
S
P
E
P
G
G
S
A
Site 30
S497
P
S
P
E
P
G
G
S
A
S
L
L
L
A
P
Site 31
S499
P
E
P
G
G
S
A
S
L
L
L
A
P
H
P
Site 32
S511
P
H
P
P
H
T
C
S
A
S
S
L
V
F
S
Site 33
S528
S
H
A
L
Q
W
I
S
Q
G
R
D
P
I
F
Site 34
S539
D
P
I
F
Q
P
P
S
P
P
K
G
L
L
T
Site 35
T546
S
P
P
K
G
L
L
T
H
P
V
A
H
S
G
Site 36
S552
L
T
H
P
V
A
H
S
G
A
S
I
L
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation