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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITIH3
Full Name:
Inter-alpha-trypsin inhibitor heavy chain H3
Alias:
ITI heavy chain H3
Type:
Mass (Da):
99831
Number AA:
890
UniProt ID:
Q06033
International Prot ID:
IPI00028413
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004857
GO:0004866
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0006022
GO:0006807
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
A
S
G
F
P
R
S
P
F
R
L
L
G
K
Site 2
S34
F
R
L
L
G
K
R
S
L
P
E
G
V
A
N
Site 3
T48
N
G
I
E
V
Y
S
T
K
I
N
S
K
V
T
Site 4
S52
V
Y
S
T
K
I
N
S
K
V
T
S
R
F
A
Site 5
S56
K
I
N
S
K
V
T
S
R
F
A
H
N
V
V
Site 6
T64
R
F
A
H
N
V
V
T
M
R
A
V
N
R
A
Site 7
T73
R
A
V
N
R
A
D
T
A
K
E
V
S
F
D
Site 8
S78
A
D
T
A
K
E
V
S
F
D
V
E
L
P
K
Site 9
Y101
L
T
I
D
G
V
T
Y
P
G
N
V
K
E
K
Site 10
S120
K
Q
Y
E
K
A
V
S
Q
G
K
T
A
G
L
Site 11
S131
T
A
G
L
V
K
A
S
G
R
K
L
E
K
F
Site 12
T155
S
K
V
T
F
E
L
T
Y
E
E
L
L
K
R
Site 13
Y167
L
K
R
H
K
G
K
Y
E
M
Y
L
K
V
Q
Site 14
Y170
H
K
G
K
Y
E
M
Y
L
K
V
Q
P
K
Q
Site 15
T214
D
L
L
G
S
A
L
T
K
S
F
S
G
K
K
Site 16
S216
L
G
S
A
L
T
K
S
F
S
G
K
K
G
H
Site 17
S218
S
A
L
T
K
S
F
S
G
K
K
G
H
V
S
Site 18
S225
S
G
K
K
G
H
V
S
F
K
P
S
L
D
Q
Site 19
S229
G
H
V
S
F
K
P
S
L
D
Q
Q
R
S
C
Site 20
S235
P
S
L
D
Q
Q
R
S
C
P
T
C
T
D
S
Site 21
T238
D
Q
Q
R
S
C
P
T
C
T
D
S
L
L
N
Site 22
S242
S
C
P
T
C
T
D
S
L
L
N
G
D
F
T
Site 23
T249
S
L
L
N
G
D
F
T
I
T
Y
D
V
N
R
Site 24
Y252
N
G
D
F
T
I
T
Y
D
V
N
R
E
S
P
Site 25
S258
T
Y
D
V
N
R
E
S
P
G
N
V
Q
I
V
Site 26
S292
V
A
F
V
I
D
I
S
G
S
M
A
G
R
K
Site 27
S294
F
V
I
D
I
S
G
S
M
A
G
R
K
L
E
Site 28
T303
A
G
R
K
L
E
Q
T
K
E
A
L
L
R
I
Site 29
Y319
E
D
M
Q
E
E
D
Y
L
N
F
I
L
F
S
Site 30
T340
K
E
H
L
V
Q
A
T
P
E
N
L
Q
E
A
Site 31
T349
E
N
L
Q
E
A
R
T
F
V
K
S
M
E
D
Site 32
S353
E
A
R
T
F
V
K
S
M
E
D
K
G
M
T
Site 33
S371
D
G
L
L
R
G
I
S
M
L
N
K
A
R
E
Site 34
S386
E
H
R
I
P
E
R
S
T
S
I
V
I
M
L
Site 35
T387
H
R
I
P
E
R
S
T
S
I
V
I
M
L
T
Site 36
S388
R
I
P
E
R
S
T
S
I
V
I
M
L
T
D
Site 37
Y423
I
G
G
K
F
P
L
Y
N
L
G
F
G
N
N
Site 38
Y433
G
F
G
N
N
L
N
Y
N
F
L
E
N
M
A
Site 39
Y451
H
G
F
A
R
R
I
Y
E
D
S
D
A
D
L
Site 40
S454
A
R
R
I
Y
E
D
S
D
A
D
L
Q
L
Q
Site 41
Y479
L
T
G
V
E
M
E
Y
P
E
N
A
I
L
D
Site 42
Y492
L
D
L
T
Q
N
T
Y
Q
H
F
Y
D
G
S
Site 43
S514
L
V
D
E
D
M
N
S
F
K
A
D
V
K
G
Site 44
T529
H
G
A
T
N
D
L
T
F
T
E
E
V
D
M
Site 45
Y548
K
A
L
Q
E
R
D
Y
I
F
G
N
Y
I
E
Site 46
Y553
R
D
Y
I
F
G
N
Y
I
E
R
L
W
A
Y
Site 47
T562
E
R
L
W
A
Y
L
T
I
E
Q
L
L
E
K
Site 48
Y592
A
L
D
L
S
L
K
Y
H
F
V
T
P
L
T
Site 49
T604
P
L
T
S
M
V
V
T
K
P
E
D
N
E
D
Site 50
T626
P
G
E
D
A
E
A
T
P
V
S
P
A
M
S
Site 51
S629
D
A
E
A
T
P
V
S
P
A
M
S
Y
L
T
Site 52
S633
T
P
V
S
P
A
M
S
Y
L
T
S
Y
Q
P
Site 53
Y634
P
V
S
P
A
M
S
Y
L
T
S
Y
Q
P
P
Site 54
S637
P
A
M
S
Y
L
T
S
Y
Q
P
P
Q
N
P
Site 55
Y638
A
M
S
Y
L
T
S
Y
Q
P
P
Q
N
P
Y
Site 56
Y645
Y
Q
P
P
Q
N
P
Y
Y
Y
V
D
G
D
P
Site 57
Y646
Q
P
P
Q
N
P
Y
Y
Y
V
D
G
D
P
H
Site 58
Y647
P
P
Q
N
P
Y
Y
Y
V
D
G
D
P
H
F
Site 59
T675
N
I
D
E
A
P
G
T
V
L
R
L
I
Q
D
Site 60
S700
I
T
G
D
K
R
G
S
P
D
S
K
T
R
K
Site 61
S703
D
K
R
G
S
P
D
S
K
T
R
K
T
Y
F
Site 62
T705
R
G
S
P
D
S
K
T
R
K
T
Y
F
G
K
Site 63
T708
P
D
S
K
T
R
K
T
Y
F
G
K
L
G
I
Site 64
Y709
D
S
K
T
R
K
T
Y
F
G
K
L
G
I
A
Site 65
T728
D
F
Q
V
E
V
T
T
E
K
I
T
L
W
N
Site 66
T741
W
N
R
A
V
P
S
T
F
S
W
L
D
T
V
Site 67
T747
S
T
F
S
W
L
D
T
V
T
V
T
Q
D
G
Site 68
S767
N
R
K
N
M
V
V
S
F
G
D
G
V
T
F
Site 69
Y795
H
R
D
F
L
G
F
Y
V
V
D
S
H
R
M
Site 70
S799
L
G
F
Y
V
V
D
S
H
R
M
S
A
Q
T
Site 71
S803
V
V
D
S
H
R
M
S
A
Q
T
H
G
L
L
Site 72
T806
S
H
R
M
S
A
Q
T
H
G
L
L
G
Q
F
Site 73
S828
V
S
D
I
R
P
G
S
D
P
T
K
P
D
A
Site 74
T836
D
P
T
K
P
D
A
T
L
V
V
K
N
H
Q
Site 75
S850
Q
L
I
V
T
R
G
S
Q
K
D
Y
R
K
D
Site 76
Y854
T
R
G
S
Q
K
D
Y
R
K
D
A
S
I
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation