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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN11
Full Name:
Tyrosine-protein phosphatase non-receptor type 11
Alias:
BPTP3; EC 3.1.3.48; NS1; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase, non-receptor 11; PTN11; PTP1D; PTP-1D; PTP2C; PTP-2C; SHP2; SHPTP2; SH-PTP2; SH-PTP3; Syp
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
68436
Number AA:
597
UniProt ID:
Q06124
International Prot ID:
IPI00658023
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004726
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
Site 2
S34
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
Site 3
S36
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
Site 4
T42
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
Site 5
S44
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
Site 6
T52
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
Site 7
T59
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
Site 8
Y62
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
Site 9
Y63
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
Site 10
Y66
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
Site 11
T73
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Site 12
Y80
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
Site 13
Y81
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
Site 14
Y100
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
Site 15
T108
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
Site 16
S118
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
Site 17
T127
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
Site 18
S134
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
Site 19
S140
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
Site 20
S142
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
Site 21
S150
H
P
G
D
F
V
L
S
V
R
T
G
D
D
K
Site 22
T153
D
F
V
L
S
V
R
T
G
D
D
K
G
E
S
Site 23
S160
T
G
D
D
K
G
E
S
N
D
G
K
S
K
V
Site 24
S165
G
E
S
N
D
G
K
S
K
V
T
H
V
M
I
Site 25
Y179
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
Site 26
S189
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Site 27
T191
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
Site 28
S228
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
Site 29
S234
E
S
R
V
R
E
L
S
K
L
A
E
T
T
D
Site 30
Y263
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Site 31
Y279
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
Site 32
T288
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
Site 33
S302
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
Site 34
Y304
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
Site 35
S321
F
E
T
K
C
N
N
S
K
P
K
K
S
Y
I
Site 36
S326
N
N
S
K
P
K
K
S
Y
I
A
T
Q
G
C
Site 37
Y327
N
S
K
P
K
K
S
Y
I
A
T
Q
G
C
L
Site 38
T330
P
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
Site 39
T356
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
Site 40
S365
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
Site 41
Y370
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
L
Site 42
Y375
V
K
Y
W
P
D
E
Y
A
L
K
E
Y
G
V
Site 43
S391
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
Site 44
Y396
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
Site 45
T397
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
Site 46
T415
Q
A
L
L
Q
G
N
T
E
R
T
V
W
Q
Y
Site 47
S434
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
Site 48
T497
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
Site 49
S503
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Site 50
Y515
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Site 51
Y519
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
Site 52
S539
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Site 53
Y546
S
K
R
K
G
H
E
Y
T
N
I
K
Y
S
L
Site 54
T547
K
R
K
G
H
E
Y
T
N
I
K
Y
S
L
A
Site 55
Y551
H
E
Y
T
N
I
K
Y
S
L
A
D
Q
T
S
Site 56
S552
E
Y
T
N
I
K
Y
S
L
A
D
Q
T
S
G
Site 57
T557
K
Y
S
L
A
D
Q
T
S
G
D
Q
S
P
L
Site 58
S558
Y
S
L
A
D
Q
T
S
G
D
Q
S
P
L
P
Site 59
S562
D
Q
T
S
G
D
Q
S
P
L
P
P
C
T
P
Site 60
T568
Q
S
P
L
P
P
C
T
P
T
P
P
C
A
E
Site 61
T570
P
L
P
P
C
T
P
T
P
P
C
A
E
M
R
Site 62
S580
C
A
E
M
R
E
D
S
A
R
V
Y
E
N
V
Site 63
Y584
R
E
D
S
A
R
V
Y
E
N
V
G
L
M
Q
Site 64
S595
G
L
M
Q
Q
Q
K
S
F
R
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation