KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPP2R3A
Full Name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Alias:
P2R3A; PPP2R3; protein phosphatase 2 (formerly 2A) regulatory subunit B', alpha; serine/threonine protein phosphatase 2A, 72/130 kDa regulatory subunit B
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
130280
Number AA:
UniProt ID:
Q06190
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000159
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0008601
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
T
Y
R
L
V
V
S
T
V
N
H
Y
S
S
Site 2
S17
S
T
V
N
H
Y
S
S
V
V
I
D
R
R
F
Site 3
S61
D
L
L
H
I
P
V
S
Q
F
K
D
A
D
L
Site 4
S70
F
K
D
A
D
L
N
S
M
F
L
P
H
E
N
Site 5
S80
L
P
H
E
N
G
L
S
S
A
E
G
D
Y
P
Site 6
Y86
L
S
S
A
E
G
D
Y
P
Q
Q
A
F
T
G
Site 7
S101
I
P
R
V
K
R
G
S
T
F
Q
N
T
Y
N
Site 8
T102
P
R
V
K
R
G
S
T
F
Q
N
T
Y
N
L
Site 9
T106
R
G
S
T
F
Q
N
T
Y
N
L
K
D
I
A
Site 10
S118
D
I
A
G
E
A
I
S
F
A
S
G
K
I
K
Site 11
S128
S
G
K
I
K
E
F
S
F
E
K
L
K
N
S
Site 12
S135
S
F
E
K
L
K
N
S
N
H
A
A
Y
R
K
Site 13
S148
R
K
G
R
K
V
K
S
D
S
F
N
R
R
S
Site 14
S150
G
R
K
V
K
S
D
S
F
N
R
R
S
V
D
Site 15
S155
S
D
S
F
N
R
R
S
V
D
L
D
L
L
C
Site 16
Y165
L
D
L
L
C
G
H
Y
N
N
D
G
N
A
P
Site 17
S173
N
N
D
G
N
A
P
S
F
G
L
L
R
S
S
Site 18
S179
P
S
F
G
L
L
R
S
S
S
V
E
E
K
P
Site 19
S180
S
F
G
L
L
R
S
S
S
V
E
E
K
P
L
Site 20
S181
F
G
L
L
R
S
S
S
V
E
E
K
P
L
S
Site 21
S188
S
V
E
E
K
P
L
S
H
R
N
S
L
D
T
Site 22
S192
K
P
L
S
H
R
N
S
L
D
T
N
L
T
S
Site 23
T195
S
H
R
N
S
L
D
T
N
L
T
S
M
F
L
Site 24
T198
N
S
L
D
T
N
L
T
S
M
F
L
Q
N
F
Site 25
S199
S
L
D
T
N
L
T
S
M
F
L
Q
N
F
S
Site 26
T212
F
S
E
E
D
L
V
T
Q
I
L
E
K
H
K
Site 27
S258
K
Q
C
I
K
K
K
S
G
S
S
I
S
E
G
Site 28
S260
C
I
K
K
K
S
G
S
S
I
S
E
G
S
G
Site 29
S261
I
K
K
K
S
G
S
S
I
S
E
G
S
G
N
Site 30
S263
K
K
S
G
S
S
I
S
E
G
S
G
N
D
T
Site 31
S266
G
S
S
I
S
E
G
S
G
N
D
T
I
S
S
Site 32
T270
S
E
G
S
G
N
D
T
I
S
S
S
E
T
V
Site 33
S272
G
S
G
N
D
T
I
S
S
S
E
T
V
Y
M
Site 34
S274
G
N
D
T
I
S
S
S
E
T
V
Y
M
N
V
Site 35
T276
D
T
I
S
S
S
E
T
V
Y
M
N
V
M
T
Site 36
S299
L
P
F
E
F
M
Q
S
G
N
N
E
A
L
D
Site 37
T308
N
N
E
A
L
D
L
T
E
L
I
S
N
M
P
Site 38
S323
S
L
Q
L
T
P
F
S
P
V
F
G
T
E
Q
Site 39
Y334
G
T
E
Q
P
P
K
Y
E
D
V
V
Q
L
S
Site 40
S341
Y
E
D
V
V
Q
L
S
A
S
D
S
G
R
F
Site 41
S343
D
V
V
Q
L
S
A
S
D
S
G
R
F
Q
T
Site 42
S345
V
Q
L
S
A
S
D
S
G
R
F
Q
T
I
E
Site 43
T350
S
D
S
G
R
F
Q
T
I
E
L
Q
N
D
K
Site 44
S360
L
Q
N
D
K
P
N
S
R
K
M
D
T
V
Q
Site 45
T365
P
N
S
R
K
M
D
T
V
Q
S
I
P
N
N
Site 46
S368
R
K
M
D
T
V
Q
S
I
P
N
N
S
T
N
Site 47
S376
I
P
N
N
S
T
N
S
L
Y
N
L
E
V
N
Site 48
T387
L
E
V
N
D
P
R
T
L
K
A
V
Q
V
Q
Site 49
S395
L
K
A
V
Q
V
Q
S
Q
S
L
T
M
N
P
Site 50
T399
Q
V
Q
S
Q
S
L
T
M
N
P
L
E
N
V
Site 51
S408
N
P
L
E
N
V
S
S
D
D
L
M
E
T
L
Site 52
T414
S
S
D
D
L
M
E
T
L
Y
I
E
E
E
S
Site 53
Y416
D
D
L
M
E
T
L
Y
I
E
E
E
S
D
G
Site 54
T433
A
L
D
K
G
Q
K
T
E
N
G
P
S
H
E
Site 55
T463
T
H
L
K
K
C
P
T
P
M
Q
N
E
I
G
Site 56
S476
I
G
K
I
F
E
K
S
F
V
N
L
P
K
E
Site 57
S487
L
P
K
E
D
C
K
S
K
V
S
K
F
E
E
Site 58
T501
E
G
D
Q
R
D
F
T
N
S
S
S
Q
E
E
Site 59
S503
D
Q
R
D
F
T
N
S
S
S
Q
E
E
I
D
Site 60
S505
R
D
F
T
N
S
S
S
Q
E
E
I
D
K
L
Site 61
S518
K
L
L
M
D
L
E
S
F
S
Q
K
M
E
T
Site 62
S520
L
M
D
L
E
S
F
S
Q
K
M
E
T
S
L
Site 63
S526
F
S
Q
K
M
E
T
S
L
R
E
P
L
A
K
Site 64
S537
P
L
A
K
G
K
N
S
N
F
L
N
S
H
S
Site 65
S544
S
N
F
L
N
S
H
S
Q
L
T
G
Q
T
L
Site 66
S558
L
V
D
L
E
P
K
S
K
V
S
S
P
I
E
Site 67
S562
E
P
K
S
K
V
S
S
P
I
E
K
V
S
P
Site 68
S568
S
S
P
I
E
K
V
S
P
S
C
L
T
R
I
Site 69
S610
Q
E
L
V
E
C
K
S
S
R
G
S
L
S
Q
Site 70
S611
E
L
V
E
C
K
S
S
R
G
S
L
S
Q
E
Site 71
S614
E
C
K
S
S
R
G
S
L
S
Q
E
K
E
M
Site 72
S616
K
S
S
R
G
S
L
S
Q
E
K
E
M
M
Q
Site 73
T628
M
M
Q
I
L
Q
E
T
L
T
T
S
S
Q
A
Site 74
T630
Q
I
L
Q
E
T
L
T
T
S
S
Q
A
N
L
Site 75
S633
Q
E
T
L
T
T
S
S
Q
A
N
L
S
V
C
Site 76
S638
T
S
S
Q
A
N
L
S
V
C
R
S
P
V
G
Site 77
S642
A
N
L
S
V
C
R
S
P
V
G
D
K
A
K
Site 78
T651
V
G
D
K
A
K
D
T
T
S
A
V
L
I
Q
Site 79
S653
D
K
A
K
D
T
T
S
A
V
L
I
Q
Q
T
Site 80
T676
K
P
E
K
K
P
G
T
P
L
P
P
P
A
T
Site 81
T683
T
P
L
P
P
P
A
T
S
P
S
S
P
R
P
Site 82
S684
P
L
P
P
P
A
T
S
P
S
S
P
R
P
L
Site 83
S686
P
P
P
A
T
S
P
S
S
P
R
P
L
S
P
Site 84
S687
P
P
A
T
S
P
S
S
P
R
P
L
S
P
V
Site 85
S692
P
S
S
P
R
P
L
S
P
V
P
H
V
N
N
Site 86
Y713
S
I
N
I
P
R
F
Y
F
P
E
G
L
P
D
Site 87
T721
F
P
E
G
L
P
D
T
C
S
N
H
E
Q
T
Site 88
S723
E
G
L
P
D
T
C
S
N
H
E
Q
T
L
S
Site 89
S730
S
N
H
E
Q
T
L
S
R
I
E
T
A
F
M
Site 90
T734
Q
T
L
S
R
I
E
T
A
F
M
D
I
E
E
Site 91
Y747
E
E
Q
K
A
D
I
Y
E
M
G
K
I
A
K
Site 92
S812
L
A
K
P
N
C
S
S
L
E
Q
E
D
F
I
Site 93
T847
E
F
H
S
R
Y
I
T
T
V
I
Q
R
I
F
Site 94
Y855
T
V
I
Q
R
I
F
Y
T
V
N
R
S
W
S
Site 95
T856
V
I
Q
R
I
F
Y
T
V
N
R
S
W
S
G
Site 96
S860
I
F
Y
T
V
N
R
S
W
S
G
K
I
T
S
Site 97
S862
Y
T
V
N
R
S
W
S
G
K
I
T
S
T
E
Site 98
T866
R
S
W
S
G
K
I
T
S
T
E
I
R
K
S
Site 99
S867
S
W
S
G
K
I
T
S
T
E
I
R
K
S
N
Site 100
T868
W
S
G
K
I
T
S
T
E
I
R
K
S
N
F
Site 101
S873
T
S
T
E
I
R
K
S
N
F
L
Q
T
L
A
Site 102
T892
E
E
D
I
N
Q
I
T
D
Y
F
S
Y
E
H
Site 103
Y894
D
I
N
Q
I
T
D
Y
F
S
Y
E
H
F
Y
Site 104
Y897
Q
I
T
D
Y
F
S
Y
E
H
F
Y
V
I
Y
Site 105
Y917
L
D
T
D
H
D
L
Y
I
S
Q
A
D
L
S
Site 106
S919
T
D
H
D
L
Y
I
S
Q
A
D
L
S
R
Y
Site 107
S924
Y
I
S
Q
A
D
L
S
R
Y
N
D
Q
A
S
Site 108
Y926
S
Q
A
D
L
S
R
Y
N
D
Q
A
S
S
S
Site 109
S931
S
R
Y
N
D
Q
A
S
S
S
R
I
I
E
R
Site 110
S932
R
Y
N
D
Q
A
S
S
S
R
I
I
E
R
I
Site 111
S933
Y
N
D
Q
A
S
S
S
R
I
I
E
R
I
F
Site 112
S941
R
I
I
E
R
I
F
S
G
A
V
T
R
G
K
Site 113
T945
R
I
F
S
G
A
V
T
R
G
K
T
I
Q
K
Site 114
T949
G
A
V
T
R
G
K
T
I
Q
K
E
G
R
M
Site 115
Y958
Q
K
E
G
R
M
S
Y
A
D
F
V
W
F
L
Site 116
S967
D
F
V
W
F
L
I
S
E
E
D
K
R
N
P
Site 117
T975
E
E
D
K
R
N
P
T
S
I
E
Y
W
F
R
Site 118
Y995
G
D
G
V
L
S
M
Y
E
L
E
Y
F
Y
E
Site 119
Y999
L
S
M
Y
E
L
E
Y
F
Y
E
E
Q
C
E
Site 120
Y1001
M
Y
E
L
E
Y
F
Y
E
E
Q
C
E
R
M
Site 121
T1038
P
A
V
D
G
K
I
T
L
R
D
L
K
R
C
Site 122
Y1061
T
F
F
N
L
E
K
Y
L
D
H
E
Q
R
D
Site 123
S1084
E
N
D
G
P
E
P
S
D
W
D
R
F
A
A
Site 124
T1096
F
A
A
E
E
Y
E
T
L
V
A
E
E
S
A
Site 125
Y1114
F
Q
E
G
F
E
D
Y
E
T
D
E
P
A
S
Site 126
T1116
E
G
F
E
D
Y
E
T
D
E
P
A
S
P
S
Site 127
S1121
Y
E
T
D
E
P
A
S
P
S
E
F
G
N
K
Site 128
S1123
T
D
E
P
A
S
P
S
E
F
G
N
K
S
N
Site 129
S1129
P
S
E
F
G
N
K
S
N
K
I
L
S
A
S
Site 130
S1134
N
K
S
N
K
I
L
S
A
S
L
P
E
K
C
Site 131
S1136
S
N
K
I
L
S
A
S
L
P
E
K
C
G
K
Site 132
S1146
E
K
C
G
K
L
Q
S
V
D
E
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation