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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSME1
Full Name:
Proteasome activator complex subunit 1
Alias:
11S regulator complex alpha; 29-kD MCP activator; Activator of multicatalytic protease 1; IFI5111; IGUP I-5111; Interferon gamma up-regulated I-5111; Interferon-gamma IEF SSP 5111; Interferon-gamma-inducible protein 5111; PA28a; PA28alpha; Proteasome (prosome, macropain) activator 1 (PA28 alpha); Proteasome activator 1; Proteasome activator 28-alpha; Proteasome activator complex 1; Proteasome activator-1; REGalpha; REG-alpha
Type:
Proteasome complex protein
Mass (Da):
28723
Number AA:
249
UniProt ID:
Q06323
International Prot ID:
IPI00030154
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0008537
Uniprot
OncoNet
Molecular Function:
GO:0008538
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
V
F
R
E
D
L
C
T
K
T
E
N
L
L
G
Site 2
T25
R
E
D
L
C
T
K
T
E
N
L
L
G
S
Y
Site 3
S31
K
T
E
N
L
L
G
S
Y
F
P
K
K
I
S
Site 4
Y32
T
E
N
L
L
G
S
Y
F
P
K
K
I
S
E
Site 5
S55
A
L
N
E
A
N
L
S
N
L
K
A
P
L
D
Site 6
S162
K
V
F
E
L
M
T
S
L
H
T
K
L
E
G
Site 7
T172
T
K
L
E
G
F
H
T
Q
I
S
K
Y
F
S
Site 8
S175
E
G
F
H
T
Q
I
S
K
Y
F
S
E
R
G
Site 9
Y177
F
H
T
Q
I
S
K
Y
F
S
E
R
G
D
A
Site 10
S179
T
Q
I
S
K
Y
F
S
E
R
G
D
A
V
T
Site 11
T186
S
E
R
G
D
A
V
T
K
A
A
K
Q
P
H
Site 12
Y197
K
Q
P
H
V
G
D
Y
R
Q
L
V
H
E
L
Site 13
Y209
H
E
L
D
E
A
E
Y
R
D
I
R
L
M
V
Site 14
Y223
V
M
E
I
R
N
A
Y
A
V
L
Y
D
I
I
Site 15
Y227
R
N
A
Y
A
V
L
Y
D
I
I
L
K
N
F
Site 16
T244
L
K
K
P
R
G
E
T
K
G
M
I
Y
_
_
Site 17
Y249
G
E
T
K
G
M
I
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation