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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TJP1
Full Name:
Tight junction protein ZO-1
Alias:
DKFZp686M05161; MGC133289; Tight junction protein 1; Tight junction protein 1 (zona occludens 1); Tight junction protein ZO-1; ZO-1; Zona occludens 1; Zona occludens protein 1; Zonula occludens 1; Zonula occludens protein 1
Type:
Adapter/scaffold protein
Mass (Da):
195459
Number AA:
1748
UniProt ID:
Q07157
International Prot ID:
IPI00216219
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016323
GO:0030054
GO:0005913
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007043
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
R
A
A
A
A
K
S
T
A
M
E
E
T
A
Site 2
T25
I
W
E
Q
H
T
V
T
L
H
R
A
P
G
F
Site 3
S39
F
G
F
G
I
A
I
S
G
G
R
D
N
P
H
Site 4
S49
R
D
N
P
H
F
Q
S
G
E
T
S
I
V
I
Site 5
S98
A
V
Q
Q
L
R
K
S
G
K
N
A
K
I
T
Site 6
T105
S
G
K
N
A
K
I
T
I
R
R
K
K
K
V
Site 7
S117
K
K
V
Q
I
P
V
S
R
P
D
P
E
P
V
Site 8
S125
R
P
D
P
E
P
V
S
D
N
E
E
D
S
Y
Site 9
S131
V
S
D
N
E
E
D
S
Y
D
E
E
I
H
D
Site 10
Y132
S
D
N
E
E
D
S
Y
D
E
E
I
H
D
P
Site 11
S141
E
E
I
H
D
P
R
S
G
R
S
G
V
V
N
Site 12
S144
H
D
P
R
S
G
R
S
G
V
V
N
R
R
S
Site 13
S151
S
G
V
V
N
R
R
S
E
K
I
W
P
R
D
Site 14
S160
K
I
W
P
R
D
R
S
A
S
R
E
R
S
L
Site 15
S162
W
P
R
D
R
S
A
S
R
E
R
S
L
S
P
Site 16
S166
R
S
A
S
R
E
R
S
L
S
P
R
S
D
R
Site 17
S168
A
S
R
E
R
S
L
S
P
R
S
D
R
R
S
Site 18
S171
E
R
S
L
S
P
R
S
D
R
R
S
V
A
S
Site 19
S175
S
P
R
S
D
R
R
S
V
A
S
S
Q
P
A
Site 20
S178
S
D
R
R
S
V
A
S
S
Q
P
A
K
P
T
Site 21
S179
D
R
R
S
V
A
S
S
Q
P
A
K
P
T
K
Site 22
T185
S
S
Q
P
A
K
P
T
K
V
T
L
V
K
S
Site 23
T188
P
A
K
P
T
K
V
T
L
V
K
S
R
K
N
Site 24
S192
T
K
V
T
L
V
K
S
R
K
N
E
E
Y
G
Site 25
Y198
K
S
R
K
N
E
E
Y
G
L
R
L
A
S
H
Site 26
S212
H
I
F
V
K
E
I
S
Q
D
S
L
A
A
R
Site 27
S215
V
K
E
I
S
Q
D
S
L
A
A
R
D
G
N
Site 28
T237
L
K
I
N
G
T
V
T
E
N
M
S
L
T
D
Site 29
T243
V
T
E
N
M
S
L
T
D
A
K
T
L
I
E
Site 30
T247
M
S
L
T
D
A
K
T
L
I
E
R
S
K
G
Site 31
T267
V
Q
R
D
E
R
A
T
L
L
N
V
P
D
L
Site 32
S275
L
L
N
V
P
D
L
S
D
S
I
H
S
A
N
Site 33
S277
N
V
P
D
L
S
D
S
I
H
S
A
N
A
S
Site 34
S280
D
L
S
D
S
I
H
S
A
N
A
S
E
R
D
Site 35
S284
S
I
H
S
A
N
A
S
E
R
D
D
I
S
E
Site 36
S290
A
S
E
R
D
D
I
S
E
I
Q
S
L
A
S
Site 37
S294
D
D
I
S
E
I
Q
S
L
A
S
D
H
S
G
Site 38
S297
S
E
I
Q
S
L
A
S
D
H
S
G
R
S
H
Site 39
S300
Q
S
L
A
S
D
H
S
G
R
S
H
D
R
P
Site 40
S303
A
S
D
H
S
G
R
S
H
D
R
P
P
R
R
Site 41
S311
H
D
R
P
P
R
R
S
R
S
R
S
P
D
Q
Site 42
S313
R
P
P
R
R
S
R
S
R
S
P
D
Q
R
S
Site 43
S315
P
R
R
S
R
S
R
S
P
D
Q
R
S
E
P
Site 44
S320
S
R
S
P
D
Q
R
S
E
P
S
D
H
S
R
Site 45
S323
P
D
Q
R
S
E
P
S
D
H
S
R
H
S
P
Site 46
S326
R
S
E
P
S
D
H
S
R
H
S
P
Q
Q
P
Site 47
S329
P
S
D
H
S
R
H
S
P
Q
Q
P
S
N
G
Site 48
S334
R
H
S
P
Q
Q
P
S
N
G
S
L
R
S
R
Site 49
S337
P
Q
Q
P
S
N
G
S
L
R
S
R
D
E
E
Site 50
S340
P
S
N
G
S
L
R
S
R
D
E
E
R
I
S
Site 51
S347
S
R
D
E
E
R
I
S
K
P
G
A
V
S
T
Site 52
S353
I
S
K
P
G
A
V
S
T
P
V
K
H
A
D
Site 53
T354
S
K
P
G
A
V
S
T
P
V
K
H
A
D
D
Site 54
T363
V
K
H
A
D
D
H
T
P
K
T
V
E
E
V
Site 55
T366
A
D
D
H
T
P
K
T
V
E
E
V
T
V
E
Site 56
T371
P
K
T
V
E
E
V
T
V
E
R
N
E
K
Q
Site 57
T379
V
E
R
N
E
K
Q
T
P
S
L
P
E
P
K
Site 58
S381
R
N
E
K
Q
T
P
S
L
P
E
P
K
P
V
Site 59
Y389
L
P
E
P
K
P
V
Y
A
Q
V
G
Q
P
D
Site 60
S402
P
D
V
D
L
P
V
S
P
S
D
G
V
L
P
Site 61
S404
V
D
L
P
V
S
P
S
D
G
V
L
P
N
S
Site 62
S411
S
D
G
V
L
P
N
S
T
H
E
D
G
I
L
Site 63
S421
E
D
G
I
L
R
P
S
M
K
L
V
K
F
R
Site 64
S432
V
K
F
R
K
G
D
S
V
G
L
R
L
A
G
Site 65
T476
R
V
N
N
V
D
F
T
N
I
I
R
E
E
A
Site 66
Y507
A
Q
K
K
K
D
V
Y
R
R
I
V
E
S
D
Site 67
S513
V
Y
R
R
I
V
E
S
D
V
G
D
S
F
Y
Site 68
S518
V
E
S
D
V
G
D
S
F
Y
I
R
T
H
F
Site 69
Y520
S
D
V
G
D
S
F
Y
I
R
T
H
F
E
Y
Site 70
Y527
Y
I
R
T
H
F
E
Y
E
K
E
S
P
Y
G
Site 71
S531
H
F
E
Y
E
K
E
S
P
Y
G
L
S
F
N
Site 72
Y533
E
Y
E
K
E
S
P
Y
G
L
S
F
N
K
G
Site 73
S536
K
E
S
P
Y
G
L
S
F
N
K
G
E
V
F
Site 74
T548
E
V
F
R
V
V
D
T
L
Y
N
G
K
L
G
Site 75
Y550
F
R
V
V
D
T
L
Y
N
G
K
L
G
S
W
Site 76
S585
N
R
A
E
Q
L
A
S
V
Q
Y
T
L
P
K
Site 77
Y588
E
Q
L
A
S
V
Q
Y
T
L
P
K
T
A
G
Site 78
T589
Q
L
A
S
V
Q
Y
T
L
P
K
T
A
G
G
Site 79
T593
V
Q
Y
T
L
P
K
T
A
G
G
D
R
A
D
Site 80
S609
W
R
F
R
G
L
R
S
S
K
R
N
L
R
K
Site 81
S610
R
F
R
G
L
R
S
S
K
R
N
L
R
K
S
Site 82
S617
S
K
R
N
L
R
K
S
R
E
D
L
S
A
Q
Site 83
S622
R
K
S
R
E
D
L
S
A
Q
P
V
Q
T
K
Site 84
Y633
V
Q
T
K
F
P
A
Y
E
R
V
V
L
R
E
Site 85
T648
A
G
F
L
R
P
V
T
I
F
G
P
I
A
D
Site 86
Y669
A
R
E
E
P
D
I
Y
Q
I
A
K
S
E
P
Site 87
S674
D
I
Y
Q
I
A
K
S
E
P
R
D
A
G
T
Site 88
T681
S
E
P
R
D
A
G
T
D
Q
R
S
S
G
I
Site 89
S686
A
G
T
D
Q
R
S
S
G
I
I
R
L
H
T
Site 90
T709
K
H
A
L
L
D
V
T
P
N
A
V
D
R
L
Site 91
Y718
N
A
V
D
R
L
N
Y
A
Q
W
Y
P
I
V
Site 92
S732
V
V
F
L
N
P
D
S
K
Q
G
V
K
T
M
Site 93
T738
D
S
K
Q
G
V
K
T
M
R
M
R
L
C
P
Site 94
S747
R
M
R
L
C
P
E
S
R
K
S
A
R
K
L
Site 95
S750
L
C
P
E
S
R
K
S
A
R
K
L
Y
E
R
Site 96
Y755
R
K
S
A
R
K
L
Y
E
R
S
H
K
L
R
Site 97
T772
N
H
H
L
F
T
T
T
I
N
L
N
S
M
N
Site 98
Y783
N
S
M
N
D
G
W
Y
G
A
L
K
E
A
I
Site 99
S810
G
K
A
D
G
A
T
S
D
D
L
D
L
H
D
Site 100
S821
D
L
H
D
D
R
L
S
Y
L
S
A
P
G
S
Site 101
Y822
L
H
D
D
R
L
S
Y
L
S
A
P
G
S
E
Site 102
S824
D
D
R
L
S
Y
L
S
A
P
G
S
E
Y
S
Site 103
S828
S
Y
L
S
A
P
G
S
E
Y
S
M
Y
S
T
Site 104
Y830
L
S
A
P
G
S
E
Y
S
M
Y
S
T
D
S
Site 105
S831
S
A
P
G
S
E
Y
S
M
Y
S
T
D
S
R
Site 106
Y833
P
G
S
E
Y
S
M
Y
S
T
D
S
R
H
T
Site 107
S834
G
S
E
Y
S
M
Y
S
T
D
S
R
H
T
S
Site 108
T835
S
E
Y
S
M
Y
S
T
D
S
R
H
T
S
D
Site 109
S837
Y
S
M
Y
S
T
D
S
R
H
T
S
D
Y
E
Site 110
T840
Y
S
T
D
S
R
H
T
S
D
Y
E
D
T
D
Site 111
S841
S
T
D
S
R
H
T
S
D
Y
E
D
T
D
T
Site 112
Y843
D
S
R
H
T
S
D
Y
E
D
T
D
T
E
G
Site 113
T846
H
T
S
D
Y
E
D
T
D
T
E
G
G
A
Y
Site 114
T848
S
D
Y
E
D
T
D
T
E
G
G
A
Y
T
D
Site 115
Y853
T
D
T
E
G
G
A
Y
T
D
Q
E
L
D
E
Site 116
T854
D
T
E
G
G
A
Y
T
D
Q
E
L
D
E
T
Site 117
T861
T
D
Q
E
L
D
E
T
L
N
D
E
V
G
T
Site 118
T868
T
L
N
D
E
V
G
T
P
P
E
S
A
I
T
Site 119
S872
E
V
G
T
P
P
E
S
A
I
T
R
S
S
E
Site 120
T875
T
P
P
E
S
A
I
T
R
S
S
E
P
V
R
Site 121
S877
P
E
S
A
I
T
R
S
S
E
P
V
R
E
D
Site 122
S878
E
S
A
I
T
R
S
S
E
P
V
R
E
D
S
Site 123
S885
S
E
P
V
R
E
D
S
S
G
M
H
H
E
N
Site 124
S886
E
P
V
R
E
D
S
S
G
M
H
H
E
N
Q
Site 125
T894
G
M
H
H
E
N
Q
T
Y
P
P
Y
S
P
Q
Site 126
Y895
M
H
H
E
N
Q
T
Y
P
P
Y
S
P
Q
A
Site 127
Y898
E
N
Q
T
Y
P
P
Y
S
P
Q
A
Q
P
Q
Site 128
S899
N
Q
T
Y
P
P
Y
S
P
Q
A
Q
P
Q
P
Site 129
S912
Q
P
I
H
R
I
D
S
P
G
F
K
P
A
S
Site 130
S919
S
P
G
F
K
P
A
S
Q
Q
K
A
E
A
S
Site 131
S926
S
Q
Q
K
A
E
A
S
S
P
V
P
Y
L
S
Site 132
S927
Q
Q
K
A
E
A
S
S
P
V
P
Y
L
S
P
Site 133
Y931
E
A
S
S
P
V
P
Y
L
S
P
E
T
N
P
Site 134
S933
S
S
P
V
P
Y
L
S
P
E
T
N
P
A
S
Site 135
T936
V
P
Y
L
S
P
E
T
N
P
A
S
S
T
S
Site 136
S940
S
P
E
T
N
P
A
S
S
T
S
A
V
N
H
Site 137
S941
P
E
T
N
P
A
S
S
T
S
A
V
N
H
N
Site 138
T960
N
V
R
L
E
E
P
T
P
A
P
S
T
S
Y
Site 139
S964
E
E
P
T
P
A
P
S
T
S
Y
S
P
Q
A
Site 140
T965
E
P
T
P
A
P
S
T
S
Y
S
P
Q
A
D
Site 141
S966
P
T
P
A
P
S
T
S
Y
S
P
Q
A
D
S
Site 142
Y967
T
P
A
P
S
T
S
Y
S
P
Q
A
D
S
L
Site 143
S968
P
A
P
S
T
S
Y
S
P
Q
A
D
S
L
R
Site 144
S973
S
Y
S
P
Q
A
D
S
L
R
T
P
S
T
E
Site 145
T976
P
Q
A
D
S
L
R
T
P
S
T
E
A
A
H
Site 146
S978
A
D
S
L
R
T
P
S
T
E
A
A
H
I
M
Site 147
T979
D
S
L
R
T
P
S
T
E
A
A
H
I
M
L
Site 148
S992
M
L
R
D
Q
E
P
S
L
S
S
H
V
D
P
Site 149
S994
R
D
Q
E
P
S
L
S
S
H
V
D
P
T
K
Site 150
Y1008
K
V
Y
R
K
D
P
Y
P
E
E
M
M
R
Q
Site 151
S1025
V
L
K
Q
P
A
V
S
H
P
G
H
R
P
D
Site 152
T1038
P
D
K
E
P
N
L
T
Y
E
P
Q
L
P
Y
Site 153
Y1039
D
K
E
P
N
L
T
Y
E
P
Q
L
P
Y
V
Site 154
Y1045
T
Y
E
P
Q
L
P
Y
V
E
K
Q
A
S
R
Site 155
S1051
P
Y
V
E
K
Q
A
S
R
D
L
E
Q
P
T
Site 156
T1058
S
R
D
L
E
Q
P
T
Y
R
Y
E
S
S
S
Site 157
Y1059
R
D
L
E
Q
P
T
Y
R
Y
E
S
S
S
Y
Site 158
Y1061
L
E
Q
P
T
Y
R
Y
E
S
S
S
Y
T
D
Site 159
S1063
Q
P
T
Y
R
Y
E
S
S
S
Y
T
D
Q
F
Site 160
S1064
P
T
Y
R
Y
E
S
S
S
Y
T
D
Q
F
S
Site 161
S1065
T
Y
R
Y
E
S
S
S
Y
T
D
Q
F
S
R
Site 162
Y1066
Y
R
Y
E
S
S
S
Y
T
D
Q
F
S
R
N
Site 163
T1067
R
Y
E
S
S
S
Y
T
D
Q
F
S
R
N
Y
Site 164
S1071
S
S
Y
T
D
Q
F
S
R
N
Y
E
H
R
L
Site 165
Y1074
T
D
Q
F
S
R
N
Y
E
H
R
L
R
Y
E
Site 166
Y1080
N
Y
E
H
R
L
R
Y
E
D
R
V
P
M
Y
Site 167
Y1087
Y
E
D
R
V
P
M
Y
E
E
Q
W
S
Y
Y
Site 168
Y1093
M
Y
E
E
Q
W
S
Y
Y
D
D
K
Q
P
Y
Site 169
Y1094
Y
E
E
Q
W
S
Y
Y
D
D
K
Q
P
Y
P
Site 170
Y1100
Y
Y
D
D
K
Q
P
Y
P
S
R
P
P
F
D
Site 171
S1102
D
D
K
Q
P
Y
P
S
R
P
P
F
D
N
Q
Site 172
S1111
P
P
F
D
N
Q
H
S
Q
D
L
D
S
R
Q
Site 173
S1116
Q
H
S
Q
D
L
D
S
R
Q
H
P
E
E
S
Site 174
S1124
R
Q
H
P
E
E
S
S
E
R
G
Y
F
P
R
Site 175
Y1128
E
E
S
S
E
R
G
Y
F
P
R
F
E
E
P
Site 176
S1139
F
E
E
P
A
P
L
S
Y
D
S
R
P
R
Y
Site 177
Y1140
E
E
P
A
P
L
S
Y
D
S
R
P
R
Y
E
Site 178
Y1146
S
Y
D
S
R
P
R
Y
E
Q
A
P
R
A
S
Site 179
S1153
Y
E
Q
A
P
R
A
S
A
L
R
H
E
E
Q
Site 180
Y1165
E
E
Q
P
A
P
G
Y
D
T
H
G
R
L
R
Site 181
T1167
Q
P
A
P
G
Y
D
T
H
G
R
L
R
P
E
Site 182
S1180
P
E
A
Q
P
H
P
S
A
G
P
K
P
A
E
Site 183
Y1191
K
P
A
E
S
K
Q
Y
F
E
Q
Y
S
R
S
Site 184
Y1195
S
K
Q
Y
F
E
Q
Y
S
R
S
Y
E
Q
V
Site 185
S1196
K
Q
Y
F
E
Q
Y
S
R
S
Y
E
Q
V
P
Site 186
S1198
Y
F
E
Q
Y
S
R
S
Y
E
Q
V
P
P
Q
Site 187
Y1199
F
E
Q
Y
S
R
S
Y
E
Q
V
P
P
Q
G
Site 188
S1229
A
V
P
P
L
I
P
S
S
Q
H
K
P
E
A
Site 189
S1230
V
P
P
L
I
P
S
S
Q
H
K
P
E
A
L
Site 190
S1239
H
K
P
E
A
L
P
S
N
T
K
P
L
P
P
Site 191
T1249
K
P
L
P
P
P
P
T
Q
T
E
E
E
E
D
Site 192
S1263
D
P
A
M
K
P
Q
S
V
L
T
R
V
K
M
Site 193
S1276
K
M
F
E
N
K
R
S
A
S
L
E
T
K
K
Site 194
S1278
F
E
N
K
R
S
A
S
L
E
T
K
K
D
V
Site 195
T1288
T
K
K
D
V
N
D
T
G
S
F
K
P
P
E
Site 196
S1290
K
D
V
N
D
T
G
S
F
K
P
P
E
V
A
Site 197
S1301
P
E
V
A
S
K
P
S
G
A
P
I
I
G
P
Site 198
S1312
I
I
G
P
K
P
T
S
Q
N
Q
F
S
E
H
Site 199
S1317
P
T
S
Q
N
Q
F
S
E
H
D
K
T
L
Y
Site 200
T1322
Q
F
S
E
H
D
K
T
L
Y
R
I
P
E
P
Site 201
Y1324
S
E
H
D
K
T
L
Y
R
I
P
E
P
Q
K
Site 202
Y1346
D
I
V
R
S
N
H
Y
D
P
E
E
D
E
E
Site 203
Y1354
D
P
E
E
D
E
E
Y
Y
R
K
Q
L
S
Y
Site 204
Y1355
P
E
E
D
E
E
Y
Y
R
K
Q
L
S
Y
F
Site 205
S1360
E
Y
Y
R
K
Q
L
S
Y
F
D
R
R
S
F
Site 206
Y1361
Y
Y
R
K
Q
L
S
Y
F
D
R
R
S
F
E
Site 207
S1366
L
S
Y
F
D
R
R
S
F
E
N
K
P
P
A
Site 208
S1381
H
I
A
A
S
H
L
S
E
P
A
K
P
A
H
Site 209
S1389
E
P
A
K
P
A
H
S
Q
N
Q
S
N
F
S
Site 210
S1393
P
A
H
S
Q
N
Q
S
N
F
S
S
Y
S
S
Site 211
S1396
S
Q
N
Q
S
N
F
S
S
Y
S
S
K
G
K
Site 212
S1397
Q
N
Q
S
N
F
S
S
Y
S
S
K
G
K
P
Site 213
S1399
Q
S
N
F
S
S
Y
S
S
K
G
K
P
P
E
Site 214
S1400
S
N
F
S
S
Y
S
S
K
G
K
P
P
E
A
Site 215
S1413
E
A
D
G
V
D
R
S
F
G
E
K
R
Y
E
Site 216
Y1419
R
S
F
G
E
K
R
Y
E
P
I
Q
A
T
P
Site 217
T1425
R
Y
E
P
I
Q
A
T
P
P
P
P
P
L
P
Site 218
S1433
P
P
P
P
P
L
P
S
Q
Y
A
Q
P
S
Q
Site 219
Y1435
P
P
P
L
P
S
Q
Y
A
Q
P
S
Q
P
V
Site 220
S1439
P
S
Q
Y
A
Q
P
S
Q
P
V
T
S
A
S
Site 221
T1443
A
Q
P
S
Q
P
V
T
S
A
S
L
H
I
H
Site 222
S1444
Q
P
S
Q
P
V
T
S
A
S
L
H
I
H
S
Site 223
S1446
S
Q
P
V
T
S
A
S
L
H
I
H
S
K
G
Site 224
S1451
S
A
S
L
H
I
H
S
K
G
A
H
G
E
G
Site 225
S1460
G
A
H
G
E
G
N
S
V
S
L
D
F
Q
N
Site 226
S1462
H
G
E
G
N
S
V
S
L
D
F
Q
N
S
L
Site 227
S1468
V
S
L
D
F
Q
N
S
L
V
S
K
P
D
P
Site 228
S1471
D
F
Q
N
S
L
V
S
K
P
D
P
P
P
S
Site 229
S1478
S
K
P
D
P
P
P
S
Q
N
K
P
A
T
F
Site 230
T1484
P
S
Q
N
K
P
A
T
F
R
P
P
N
R
E
Site 231
T1493
R
P
P
N
R
E
D
T
A
Q
A
A
F
Y
P
Site 232
Y1499
D
T
A
Q
A
A
F
Y
P
Q
K
S
F
P
D
Site 233
S1503
A
A
F
Y
P
Q
K
S
F
P
D
K
A
P
V
Site 234
T1519
G
T
E
Q
T
Q
K
T
V
T
P
A
Y
N
R
Site 235
T1521
E
Q
T
Q
K
T
V
T
P
A
Y
N
R
F
T
Site 236
Y1524
Q
K
T
V
T
P
A
Y
N
R
F
T
P
K
P
Site 237
T1528
T
P
A
Y
N
R
F
T
P
K
P
Y
T
S
S
Site 238
Y1532
N
R
F
T
P
K
P
Y
T
S
S
A
R
P
F
Site 239
T1533
R
F
T
P
K
P
Y
T
S
S
A
R
P
F
E
Site 240
S1534
F
T
P
K
P
Y
T
S
S
A
R
P
F
E
R
Site 241
S1535
T
P
K
P
Y
T
S
S
A
R
P
F
E
R
K
Site 242
S1545
P
F
E
R
K
F
E
S
P
K
F
N
H
N
L
Site 243
S1564
T
A
H
K
P
D
L
S
S
K
T
P
T
S
P
Site 244
S1565
A
H
K
P
D
L
S
S
K
T
P
T
S
P
K
Site 245
T1567
K
P
D
L
S
S
K
T
P
T
S
P
K
T
L
Site 246
T1569
D
L
S
S
K
T
P
T
S
P
K
T
L
V
K
Site 247
S1570
L
S
S
K
T
P
T
S
P
K
T
L
V
K
S
Site 248
T1573
K
T
P
T
S
P
K
T
L
V
K
S
H
S
L
Site 249
S1577
S
P
K
T
L
V
K
S
H
S
L
A
Q
P
P
Site 250
S1579
K
T
L
V
K
S
H
S
L
A
Q
P
P
E
F
Site 251
S1588
A
Q
P
P
E
F
D
S
G
V
E
T
F
S
I
Site 252
T1592
E
F
D
S
G
V
E
T
F
S
I
H
A
E
K
Site 253
Y1602
I
H
A
E
K
P
K
Y
Q
I
N
N
I
S
T
Site 254
S1617
V
P
K
A
I
P
V
S
P
S
A
V
E
E
D
Site 255
S1619
K
A
I
P
V
S
P
S
A
V
E
E
D
E
D
Site 256
T1631
D
E
D
E
D
G
H
T
V
V
A
T
A
R
G
Site 257
S1642
T
A
R
G
I
F
N
S
N
G
G
V
L
S
S
Site 258
S1648
N
S
N
G
G
V
L
S
S
I
E
T
G
V
S
Site 259
S1655
S
S
I
E
T
G
V
S
I
I
I
P
Q
G
A
Site 260
Y1672
E
G
V
E
Q
E
I
Y
F
K
V
C
R
D
N
Site 261
S1680
F
K
V
C
R
D
N
S
I
L
P
P
L
D
K
Site 262
T1692
L
D
K
E
K
G
E
T
L
L
S
P
L
V
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation