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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLE
Full Name:
DNA polymerase epsilon catalytic subunit A
Alias:
DNA polymerase II subunit A; DPOE1; EC 2.7.7.7; POLE1; Polymerase (DNA directed) epsilon
Type:
Transferase, DNA replication, DNA repair, Nucleotide Metabolism group, Pyrimidine metabolism family, Purine metabolism family
Mass (Da):
261518
Number AA:
2286
UniProt ID:
Q07864
International Prot ID:
IPI00939602
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0000731
GO:0000082
GO:0006297
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
P
G
A
D
G
E
A
S
R
D
D
G
A
T
S
Site 2
T26
A
S
R
D
D
G
A
T
S
S
V
S
A
L
K
Site 3
S27
S
R
D
D
G
A
T
S
S
V
S
A
L
K
R
Site 4
S28
R
D
D
G
A
T
S
S
V
S
A
L
K
R
L
Site 5
S38
A
L
K
R
L
E
R
S
Q
W
T
D
K
M
D
Site 6
S80
D
E
D
K
R
L
G
S
A
V
D
Y
Y
F
I
Site 7
Y84
R
L
G
S
A
V
D
Y
Y
F
I
Q
D
D
G
Site 8
Y85
L
G
S
A
V
D
Y
Y
F
I
Q
D
D
G
S
Site 9
S92
Y
F
I
Q
D
D
G
S
R
F
K
V
A
L
P
Site 10
Y100
R
F
K
V
A
L
P
Y
K
P
Y
F
Y
I
A
Site 11
Y103
V
A
L
P
Y
K
P
Y
F
Y
I
A
T
R
K
Site 12
Y105
L
P
Y
K
P
Y
F
Y
I
A
T
R
K
G
C
Site 13
S117
K
G
C
E
R
E
V
S
S
F
L
S
K
K
F
Site 14
S118
G
C
E
R
E
V
S
S
F
L
S
K
K
F
Q
Site 15
S121
R
E
V
S
S
F
L
S
K
K
F
Q
G
K
I
Site 16
T133
G
K
I
A
K
V
E
T
V
P
K
E
D
L
D
Site 17
Y152
L
V
G
L
K
R
N
Y
I
R
L
S
F
H
T
Site 18
S156
K
R
N
Y
I
R
L
S
F
H
T
V
E
D
L
Site 19
S171
V
K
V
R
K
E
I
S
P
A
V
K
K
N
R
Site 20
S184
N
R
E
Q
D
H
A
S
D
A
Y
T
A
L
L
Site 21
Y187
Q
D
H
A
S
D
A
Y
T
A
L
L
S
S
V
Site 22
T202
L
Q
R
G
G
V
I
T
D
E
E
E
T
S
K
Site 23
S208
I
T
D
E
E
E
T
S
K
K
I
A
D
Q
L
Site 24
Y224
N
I
V
D
M
R
E
Y
D
V
P
Y
H
I
R
Site 25
Y228
M
R
E
Y
D
V
P
Y
H
I
R
L
S
I
D
Site 26
T290
L
K
F
P
D
A
E
T
D
Q
I
M
M
I
S
Site 27
T308
D
G
Q
G
Y
L
I
T
N
R
E
I
V
S
E
Site 28
T323
D
I
E
D
F
E
F
T
P
K
P
E
Y
E
G
Site 29
Y328
E
F
T
P
K
P
E
Y
E
G
P
F
C
V
F
Site 30
T357
H
V
Q
E
T
K
P
T
I
M
V
T
Y
N
G
Site 31
S382
R
A
A
V
H
G
L
S
M
Q
Q
E
I
G
F
Site 32
S393
E
I
G
F
Q
K
D
S
Q
G
E
Y
K
A
P
Site 33
Y397
Q
K
D
S
Q
G
E
Y
K
A
P
Q
C
I
H
Site 34
S415
L
R
W
V
K
R
D
S
Y
L
P
V
G
S
H
Site 35
Y416
R
W
V
K
R
D
S
Y
L
P
V
G
S
H
N
Site 36
T449
E
D
M
C
R
M
A
T
E
Q
P
Q
T
L
A
Site 37
T454
M
A
T
E
Q
P
Q
T
L
A
T
Y
S
V
S
Site 38
T457
E
Q
P
Q
T
L
A
T
Y
S
V
S
D
A
V
Site 39
Y468
S
D
A
V
A
T
Y
Y
L
Y
M
K
Y
V
H
Site 40
S497
D
E
V
L
R
K
G
S
G
T
L
C
E
A
L
Site 41
S536
D
D
G
H
V
L
D
S
E
T
Y
V
G
G
H
Site 42
T538
G
H
V
L
D
S
E
T
Y
V
G
G
H
V
E
Site 43
Y539
H
V
L
D
S
E
T
Y
V
G
G
H
V
E
A
Site 44
S549
G
H
V
E
A
L
E
S
G
V
F
R
S
D
I
Site 45
S554
L
E
S
G
V
F
R
S
D
I
P
C
R
F
R
Site 46
T577
L
L
Q
R
V
E
K
T
L
R
H
A
L
E
E
Site 47
S605
E
V
C
D
E
I
K
S
K
L
A
S
L
K
D
Site 48
S609
E
I
K
S
K
L
A
S
L
K
D
V
P
S
R
Site 49
T637
M
Y
P
N
I
I
L
T
N
R
L
Q
P
S
A
Site 50
S679
R
G
E
F
M
P
A
S
R
S
E
Y
H
R
I
Site 51
S681
E
F
M
P
A
S
R
S
E
Y
H
R
I
Q
H
Site 52
Y683
M
P
A
S
R
S
E
Y
H
R
I
Q
H
Q
L
Site 53
S711
A
R
A
F
H
E
L
S
R
E
E
Q
A
K
Y
Site 54
Y718
S
R
E
E
Q
A
K
Y
E
K
R
R
L
A
D
Site 55
Y726
E
K
R
R
L
A
D
Y
C
R
K
A
Y
K
K
Site 56
Y731
A
D
Y
C
R
K
A
Y
K
K
I
H
I
T
K
Site 57
T744
T
K
V
E
E
R
L
T
T
I
C
Q
R
E
N
Site 58
T745
K
V
E
E
R
L
T
T
I
C
Q
R
E
N
S
Site 59
S752
T
I
C
Q
R
E
N
S
F
Y
V
D
T
V
R
Site 60
Y754
C
Q
R
E
N
S
F
Y
V
D
T
V
R
A
F
Site 61
T757
E
N
S
F
Y
V
D
T
V
R
A
F
R
D
R
Site 62
Y766
R
A
F
R
D
R
R
Y
E
F
K
G
L
H
K
Site 63
S780
K
V
W
K
K
K
L
S
A
A
V
E
V
G
D
Site 64
Y801
C
K
N
M
E
V
L
Y
D
S
L
Q
L
A
H
Site 65
Y816
K
C
I
L
N
S
F
Y
G
Y
V
M
R
K
G
Site 66
Y818
I
L
N
S
F
Y
G
Y
V
M
R
K
G
A
R
Site 67
Y827
M
R
K
G
A
R
W
Y
S
M
E
M
A
G
I
Site 68
T880
P
E
N
F
V
F
K
T
T
N
V
K
K
P
K
Site 69
S891
K
K
P
K
V
T
I
S
Y
P
G
A
M
L
N
Site 70
Y910
E
G
F
T
N
D
Q
Y
Q
E
L
A
E
P
S
Site 71
S918
Q
E
L
A
E
P
S
S
L
T
Y
V
T
R
S
Site 72
Y921
A
E
P
S
S
L
T
Y
V
T
R
S
E
N
S
Site 73
S945
L
A
M
I
L
P
A
S
K
E
E
G
K
K
L
Site 74
S1005
T
L
E
E
V
Y
G
S
V
A
K
V
A
D
Y
Site 75
Y1018
D
Y
W
L
D
V
L
Y
S
K
A
A
N
M
P
Site 76
S1027
K
A
A
N
M
P
D
S
E
L
F
E
L
I
S
Site 77
S1034
S
E
L
F
E
L
I
S
E
N
R
S
M
S
R
Site 78
S1038
E
L
I
S
E
N
R
S
M
S
R
K
L
E
D
Site 79
S1040
I
S
E
N
R
S
M
S
R
K
L
E
D
Y
G
Site 80
Y1046
M
S
R
K
L
E
D
Y
G
E
Q
K
S
T
S
Site 81
S1051
E
D
Y
G
E
Q
K
S
T
S
I
S
T
A
K
Site 82
T1052
D
Y
G
E
Q
K
S
T
S
I
S
T
A
K
R
Site 83
S1053
Y
G
E
Q
K
S
T
S
I
S
T
A
K
R
L
Site 84
S1055
E
Q
K
S
T
S
I
S
T
A
K
R
L
A
E
Site 85
S1081
L
S
C
R
Y
I
I
S
R
K
P
E
G
S
P
Site 86
S1087
I
S
R
K
P
E
G
S
P
V
T
E
R
A
I
Site 87
T1090
K
P
E
G
S
P
V
T
E
R
A
I
P
L
A
Site 88
T1104
A
I
F
Q
A
E
P
T
V
R
K
H
F
L
R
Site 89
S1116
F
L
R
K
W
L
K
S
S
S
L
Q
D
F
D
Site 90
S1118
R
K
W
L
K
S
S
S
L
Q
D
F
D
I
R
Site 91
Y1132
R
A
I
L
D
W
D
Y
Y
I
E
R
L
G
S
Site 92
Y1133
A
I
L
D
W
D
Y
Y
I
E
R
L
G
S
A
Site 93
Y1178
L
L
E
K
N
D
V
Y
K
Q
K
K
I
S
E
Site 94
S1184
V
Y
K
Q
K
K
I
S
E
L
F
T
L
E
G
Site 95
T1188
K
K
I
S
E
L
F
T
L
E
G
R
R
Q
V
Site 96
T1196
L
E
G
R
R
Q
V
T
M
A
E
A
S
E
D
Site 97
S1201
Q
V
T
M
A
E
A
S
E
D
S
P
R
P
S
Site 98
S1204
M
A
E
A
S
E
D
S
P
R
P
S
A
P
D
Site 99
S1208
S
E
D
S
P
R
P
S
A
P
D
M
E
D
F
Site 100
T1228
P
H
P
A
A
P
V
T
V
K
R
K
R
V
L
Site 101
S1238
R
K
R
V
L
W
E
S
Q
E
E
S
Q
D
L
Site 102
S1242
L
W
E
S
Q
E
E
S
Q
D
L
T
P
T
V
Site 103
T1246
Q
E
E
S
Q
D
L
T
P
T
V
P
W
Q
E
Site 104
T1248
E
S
Q
D
L
T
P
T
V
P
W
Q
E
I
L
Site 105
S1264
Q
P
P
A
L
G
T
S
Q
E
E
W
L
V
W
Site 106
S1297
R
K
R
Q
R
L
E
S
A
E
G
V
L
R
P
Site 107
S1317
G
P
A
T
G
L
G
S
F
L
R
R
T
A
R
Site 108
S1325
F
L
R
R
T
A
R
S
I
L
D
L
P
W
Q
Site 109
S1380
A
K
A
E
E
G
A
S
Y
R
K
V
N
R
V
Site 110
Y1381
K
A
E
E
G
A
S
Y
R
K
V
N
R
V
L
Site 111
Y1395
L
P
R
S
N
M
V
Y
N
L
Y
E
Y
S
V
Site 112
Y1398
S
N
M
V
Y
N
L
Y
E
Y
S
V
P
E
D
Site 113
Y1400
M
V
Y
N
L
Y
E
Y
S
V
P
E
D
M
Y
Site 114
Y1407
Y
S
V
P
E
D
M
Y
Q
E
H
I
N
E
I
Site 115
S1456
K
Q
L
V
R
H
L
S
G
W
E
A
E
T
F
Site 116
T1462
L
S
G
W
E
A
E
T
F
A
L
E
H
L
E
Site 117
S1472
L
E
H
L
E
M
R
S
L
A
Q
F
S
Y
L
Site 118
S1477
M
R
S
L
A
Q
F
S
Y
L
E
P
G
S
I
Site 119
Y1478
R
S
L
A
Q
F
S
Y
L
E
P
G
S
I
R
Site 120
S1483
F
S
Y
L
E
P
G
S
I
R
H
I
Y
L
Y
Site 121
Y1488
P
G
S
I
R
H
I
Y
L
Y
H
H
A
Q
A
Site 122
Y1490
S
I
R
H
I
Y
L
Y
H
H
A
Q
A
H
K
Site 123
S1520
F
V
L
D
T
V
R
S
N
Q
M
P
S
L
G
Site 124
S1525
V
R
S
N
Q
M
P
S
L
G
A
L
Y
S
A
Site 125
T1552
L
L
P
P
P
K
H
T
F
E
V
R
A
E
T
Site 126
T1559
T
F
E
V
R
A
E
T
D
L
K
T
I
C
R
Site 127
T1563
R
A
E
T
D
L
K
T
I
C
R
A
I
Q
R
Site 128
Y1575
I
Q
R
F
L
L
A
Y
K
E
E
R
R
G
P
Site 129
T1583
K
E
E
R
R
G
P
T
L
I
A
V
Q
S
S
Site 130
S1589
P
T
L
I
A
V
Q
S
S
W
E
L
K
R
L
Site 131
S1598
W
E
L
K
R
L
A
S
E
I
P
V
L
E
E
Site 132
Y1636
A
R
R
M
I
R
H
Y
L
N
L
D
T
C
L
Site 133
T1641
R
H
Y
L
N
L
D
T
C
L
S
Q
A
F
E
Site 134
S1644
L
N
L
D
T
C
L
S
Q
A
F
E
M
S
R
Site 135
Y1652
Q
A
F
E
M
S
R
Y
F
H
I
P
I
G
N
Site 136
S1665
G
N
L
P
E
D
I
S
T
F
G
S
D
L
F
Site 137
S1669
E
D
I
S
T
F
G
S
D
L
F
F
A
R
H
Site 138
S1687
H
N
H
L
L
W
L
S
P
T
A
R
P
D
L
Site 139
T1689
H
L
L
W
L
S
P
T
A
R
P
D
L
G
G
Site 140
T1713
M
E
F
D
D
Q
A
T
V
E
I
N
S
S
G
Site 141
S1753
N
D
M
E
G
A
D
S
M
G
I
S
F
D
V
Site 142
S1777
I
T
G
G
Q
A
A
S
A
P
A
S
Y
D
E
Site 143
S1781
Q
A
A
S
A
P
A
S
Y
D
E
T
A
L
C
Site 144
T1785
A
P
A
S
Y
D
E
T
A
L
C
S
N
T
F
Site 145
S1797
N
T
F
R
I
L
K
S
M
V
V
G
W
V
K
Site 146
Y1809
W
V
K
E
I
T
Q
Y
H
N
I
Y
A
D
N
Site 147
S1827
H
F
Y
R
W
L
R
S
P
S
S
L
L
H
D
Site 148
S1829
Y
R
W
L
R
S
P
S
S
L
L
H
D
P
A
Site 149
S1830
R
W
L
R
S
P
S
S
L
L
H
D
P
A
L
Site 150
T1875
F
N
R
I
I
L
C
T
K
K
R
R
V
E
D
Site 151
Y1886
R
V
E
D
A
I
A
Y
V
E
Y
I
T
S
S
Site 152
S1892
A
Y
V
E
Y
I
T
S
S
I
H
S
K
E
T
Site 153
S1896
Y
I
T
S
S
I
H
S
K
E
T
F
H
S
L
Site 154
T1899
S
S
I
H
S
K
E
T
F
H
S
L
T
I
S
Site 155
S1902
H
S
K
E
T
F
H
S
L
T
I
S
F
S
R
Site 156
T1904
K
E
T
F
H
S
L
T
I
S
F
S
R
C
W
Site 157
Y1922
L
W
M
D
P
S
N
Y
G
G
I
K
G
K
V
Site 158
S1930
G
G
I
K
G
K
V
S
S
R
I
H
C
G
L
Site 159
S1931
G
I
K
G
K
V
S
S
R
I
H
C
G
L
Q
Site 160
S1940
I
H
C
G
L
Q
D
S
Q
K
A
G
G
A
E
Site 161
S1970
E
E
E
E
A
E
E
S
N
V
E
D
L
L
E
Site 162
S2018
M
K
D
G
L
R
R
S
A
P
G
S
T
P
V
Site 163
S2022
L
R
R
S
A
P
G
S
T
P
V
R
R
R
G
Site 164
T2023
R
R
S
A
P
G
S
T
P
V
R
R
R
G
A
Site 165
S2031
P
V
R
R
R
G
A
S
Q
L
S
Q
E
A
E
Site 166
S2034
R
R
G
A
S
Q
L
S
Q
E
A
E
G
A
V
Site 167
S2051
L
P
G
M
I
T
F
S
Q
D
Y
V
A
N
E
Site 168
Y2054
M
I
T
F
S
Q
D
Y
V
A
N
E
L
T
Q
Site 169
S2062
V
A
N
E
L
T
Q
S
F
F
T
I
T
Q
K
Site 170
S2080
K
V
T
G
S
R
N
S
T
E
L
S
E
M
F
Site 171
T2081
V
T
G
S
R
N
S
T
E
L
S
E
M
F
P
Site 172
S2084
S
R
N
S
T
E
L
S
E
M
F
P
V
L
P
Site 173
S2150
Q
F
R
D
P
C
R
S
Y
V
L
P
E
V
I
Site 174
S2173
D
L
D
L
C
K
D
S
S
F
S
E
D
G
A
Site 175
S2174
L
D
L
C
K
D
S
S
F
S
E
D
G
A
V
Site 176
T2230
K
C
R
G
V
K
E
T
S
M
P
V
Y
C
S
Site 177
Y2235
K
E
T
S
M
P
V
Y
C
S
C
A
G
D
F
Site 178
Y2269
A
Q
H
Y
G
M
S
Y
L
L
E
T
L
E
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation