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Updated November 2019
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Protein Info
Short Name:
Sos1
Full Name:
Son of sevenless homolog 1
Alias:
GF1; GGF1; GINGF; Gingival fibromatosis; Gingival fibromatosis, hereditary, 1; HGF; RasGEF; RasGef1; Ras-Gef1; Son of sevenless 1; Son of sevenless protein homolog 1; Sos-1
Type:
Guanine nucleotide exchange factor, Ras; Adaptor/scaffold
Mass (Da):
152464
Number AA:
1333
UniProt ID:
Q07889
International Prot ID:
IPI00020131
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005100
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y47
S
N
D
D
A
L
Q
Y
V
E
E
L
I
L
Q
Site 2
S66
L
C
Q
A
Q
P
R
S
A
S
D
V
E
E
R
Site 3
S68
Q
A
Q
P
R
S
A
S
D
V
E
E
R
V
Q
Site 4
S77
V
E
E
R
V
Q
K
S
F
P
H
P
I
D
K
Site 5
S104
R
K
R
R
N
P
L
S
L
P
V
E
K
I
H
Site 6
Y120
L
L
K
E
V
L
G
Y
K
I
D
H
Q
V
S
Site 7
Y148
I
L
K
L
V
G
N
Y
V
R
N
I
R
H
Y
Site 8
Y155
Y
V
R
N
I
R
H
Y
E
I
T
K
Q
D
I
Site 9
T158
N
I
R
H
Y
E
I
T
K
Q
D
I
K
V
A
Site 10
S187
V
E
D
I
N
I
L
S
L
T
D
E
E
P
S
Site 11
T189
D
I
N
I
L
S
L
T
D
E
E
P
S
T
S
Site 12
S194
S
L
T
D
E
E
P
S
T
S
G
E
Q
T
Y
Site 13
T195
L
T
D
E
E
P
S
T
S
G
E
Q
T
Y
Y
Site 14
S196
T
D
E
E
P
S
T
S
G
E
Q
T
Y
Y
D
Site 15
T200
P
S
T
S
G
E
Q
T
Y
Y
D
L
V
K
A
Site 16
Y202
T
S
G
E
Q
T
Y
Y
D
L
V
K
A
F
M
Site 17
Y215
F
M
A
E
I
R
Q
Y
I
R
E
L
N
L
I
Site 18
S234
R
E
P
F
V
S
N
S
K
L
F
S
A
N
D
Site 19
S238
V
S
N
S
K
L
F
S
A
N
D
V
E
N
I
Site 20
T266
L
L
G
H
I
E
D
T
V
E
M
T
D
E
G
Site 21
T270
I
E
D
T
V
E
M
T
D
E
G
S
P
H
P
Site 22
S274
V
E
M
T
D
E
G
S
P
H
P
L
V
G
S
Site 23
Y295
E
E
L
A
F
D
P
Y
E
S
Y
A
R
D
I
Site 24
Y298
A
F
D
P
Y
E
S
Y
A
R
D
I
L
R
P
Site 25
S313
G
F
H
D
R
F
L
S
Q
L
S
K
P
G
A
Site 26
S316
D
R
F
L
S
Q
L
S
K
P
G
A
A
L
Y
Site 27
Y323
S
K
P
G
A
A
L
Y
L
Q
S
I
G
E
G
Site 28
S364
L
K
Q
L
E
E
K
S
E
D
Q
E
D
K
E
Site 29
S392
S
G
M
E
K
I
C
S
K
S
L
A
K
R
R
Site 30
S394
M
E
K
I
C
S
K
S
L
A
K
R
R
L
S
Site 31
S401
S
L
A
K
R
R
L
S
E
S
A
C
R
F
Y
Site 32
S403
A
K
R
R
L
S
E
S
A
C
R
F
Y
S
Q
Site 33
Y408
S
E
S
A
C
R
F
Y
S
Q
Q
M
K
G
K
Site 34
S409
E
S
A
C
R
F
Y
S
Q
Q
M
K
G
K
Q
Site 35
T451
F
I
M
E
G
T
L
T
R
V
G
A
K
H
E
Site 36
S484
Q
P
R
L
P
G
A
S
N
A
E
Y
R
L
K
Site 37
Y488
P
G
A
S
N
A
E
Y
R
L
K
E
K
F
F
Site 38
Y510
D
K
D
D
T
N
E
Y
K
H
A
F
E
I
I
Site 39
S523
I
I
L
K
D
E
N
S
V
I
F
S
A
K
S
Site 40
S527
D
E
N
S
V
I
F
S
A
K
S
A
E
E
K
Site 41
S530
S
V
I
F
S
A
K
S
A
E
E
K
N
N
W
Site 42
T549
I
S
L
Q
Y
R
S
T
L
E
R
M
L
D
V
Site 43
T557
L
E
R
M
L
D
V
T
M
L
Q
E
E
K
E
Site 44
S571
E
E
Q
M
R
L
P
S
A
D
V
Y
R
F
A
Site 45
Y575
R
L
P
S
A
D
V
Y
R
F
A
E
P
D
S
Site 46
S582
Y
R
F
A
E
P
D
S
E
E
N
I
I
F
E
Site 47
T614
I
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Site 48
Y615
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
N
Site 49
Y618
E
R
L
T
Y
H
M
Y
A
D
P
N
F
V
R
Site 50
T626
A
D
P
N
F
V
R
T
F
L
T
T
Y
R
S
Site 51
T630
F
V
R
T
F
L
T
T
Y
R
S
F
C
K
P
Site 52
Y631
V
R
T
F
L
T
T
Y
R
S
F
C
K
P
Q
Site 53
S633
T
F
L
T
T
Y
R
S
F
C
K
P
Q
E
L
Site 54
S642
C
K
P
Q
E
L
L
S
L
I
I
E
R
F
E
Site 55
T656
E
I
P
E
P
E
P
T
E
A
D
R
I
A
I
Site 56
S671
E
N
G
D
Q
P
L
S
A
E
L
K
R
F
R
Site 57
Y681
L
K
R
F
R
K
E
Y
I
Q
P
V
Q
L
R
Site 58
Y709
Y
D
F
E
R
D
A
Y
L
L
Q
R
M
E
E
Site 59
T720
R
M
E
E
F
I
G
T
V
R
G
K
A
M
K
Site 60
T753
N
G
P
G
H
N
I
T
F
Q
S
S
P
P
T
Site 61
S757
H
N
I
T
F
Q
S
S
P
P
T
V
E
W
H
Site 62
T760
T
F
Q
S
S
P
P
T
V
E
W
H
I
S
R
Site 63
T773
S
R
P
G
H
I
E
T
F
D
L
L
T
L
H
Site 64
S793
R
Q
L
T
L
L
E
S
D
L
Y
R
A
V
Q
Site 65
Y796
T
L
L
E
S
D
L
Y
R
A
V
Q
P
S
E
Site 66
S802
L
Y
R
A
V
Q
P
S
E
L
V
G
S
V
W
Site 67
S807
Q
P
S
E
L
V
G
S
V
W
T
K
E
D
K
Site 68
S818
K
E
D
K
E
I
N
S
P
N
L
L
K
M
I
Site 69
S880
E
V
V
S
A
M
N
S
S
P
V
Y
R
L
D
Site 70
S881
V
V
S
A
M
N
S
S
P
V
Y
R
L
D
H
Site 71
Y884
A
M
N
S
S
P
V
Y
R
L
D
H
T
F
E
Site 72
T889
P
V
Y
R
L
D
H
T
F
E
Q
I
P
S
R
Site 73
S895
H
T
F
E
Q
I
P
S
R
Q
K
K
I
L
E
Site 74
Y912
H
E
L
S
E
D
H
Y
K
K
Y
L
A
K
L
Site 75
Y915
S
E
D
H
Y
K
K
Y
L
A
K
L
R
S
I
Site 76
S921
K
Y
L
A
K
L
R
S
I
N
P
P
C
V
P
Site 77
T940
Y
L
T
N
I
L
K
T
E
E
G
N
P
E
V
Site 78
S959
G
K
E
L
I
N
F
S
K
R
R
K
V
A
E
Site 79
Y974
I
T
G
E
I
Q
Q
Y
Q
N
Q
P
Y
C
L
Site 80
Y979
Q
Q
Y
Q
N
Q
P
Y
C
L
R
V
E
S
D
Site 81
S985
P
Y
C
L
R
V
E
S
D
I
K
R
F
F
E
Site 82
T1006
N
S
M
E
K
E
F
T
D
Y
L
F
N
K
S
Site 83
Y1008
M
E
K
E
F
T
D
Y
L
F
N
K
S
L
E
Site 84
S1013
T
D
Y
L
F
N
K
S
L
E
I
E
P
R
N
Site 85
Y1031
L
P
R
F
P
K
K
Y
S
Y
P
L
K
S
P
Site 86
S1032
P
R
F
P
K
K
Y
S
Y
P
L
K
S
P
G
Site 87
Y1033
R
F
P
K
K
Y
S
Y
P
L
K
S
P
G
V
Site 88
S1037
K
Y
S
Y
P
L
K
S
P
G
V
R
P
S
N
Site 89
S1043
K
S
P
G
V
R
P
S
N
P
R
P
G
T
M
Site 90
T1049
P
S
N
P
R
P
G
T
M
R
H
P
T
P
L
Site 91
T1054
P
G
T
M
R
H
P
T
P
L
Q
Q
E
P
R
Site 92
S1064
Q
Q
E
P
R
K
I
S
Y
S
R
I
P
E
S
Site 93
Y1065
Q
E
P
R
K
I
S
Y
S
R
I
P
E
S
E
Site 94
S1066
E
P
R
K
I
S
Y
S
R
I
P
E
S
E
T
Site 95
S1071
S
Y
S
R
I
P
E
S
E
T
E
S
T
A
S
Site 96
T1073
S
R
I
P
E
S
E
T
E
S
T
A
S
A
P
Site 97
S1075
I
P
E
S
E
T
E
S
T
A
S
A
P
N
S
Site 98
T1076
P
E
S
E
T
E
S
T
A
S
A
P
N
S
P
Site 99
S1078
S
E
T
E
S
T
A
S
A
P
N
S
P
R
T
Site 100
S1082
S
T
A
S
A
P
N
S
P
R
T
P
L
T
P
Site 101
T1085
S
A
P
N
S
P
R
T
P
L
T
P
P
P
A
Site 102
T1088
N
S
P
R
T
P
L
T
P
P
P
A
S
G
A
Site 103
S1093
P
L
T
P
P
P
A
S
G
A
S
S
T
T
D
Site 104
S1097
P
P
A
S
G
A
S
S
T
T
D
V
C
S
V
Site 105
S1103
S
S
T
T
D
V
C
S
V
F
D
S
D
H
S
Site 106
S1107
D
V
C
S
V
F
D
S
D
H
S
S
P
F
H
Site 107
S1110
S
V
F
D
S
D
H
S
S
P
F
H
S
S
N
Site 108
S1111
V
F
D
S
D
H
S
S
P
F
H
S
S
N
D
Site 109
S1115
D
H
S
S
P
F
H
S
S
N
D
T
V
F
I
Site 110
S1116
H
S
S
P
F
H
S
S
N
D
T
V
F
I
Q
Site 111
T1125
D
T
V
F
I
Q
V
T
L
P
H
G
P
R
S
Site 112
S1132
T
L
P
H
G
P
R
S
A
S
V
S
S
I
S
Site 113
S1134
P
H
G
P
R
S
A
S
V
S
S
I
S
L
T
Site 114
S1136
G
P
R
S
A
S
V
S
S
I
S
L
T
K
G
Site 115
S1137
P
R
S
A
S
V
S
S
I
S
L
T
K
G
T
Site 116
S1139
S
A
S
V
S
S
I
S
L
T
K
G
T
D
E
Site 117
T1141
S
V
S
S
I
S
L
T
K
G
T
D
E
V
P
Site 118
S1161
P
P
R
R
R
P
E
S
A
P
A
E
S
S
P
Site 119
S1166
P
E
S
A
P
A
E
S
S
P
S
K
I
M
S
Site 120
S1167
E
S
A
P
A
E
S
S
P
S
K
I
M
S
K
Site 121
S1169
A
P
A
E
S
S
P
S
K
I
M
S
K
H
L
Site 122
S1173
S
S
P
S
K
I
M
S
K
H
L
D
S
P
P
Site 123
S1178
I
M
S
K
H
L
D
S
P
P
A
I
P
P
R
Site 124
T1188
A
I
P
P
R
Q
P
T
S
K
A
Y
S
P
R
Site 125
S1189
I
P
P
R
Q
P
T
S
K
A
Y
S
P
R
Y
Site 126
S1193
Q
P
T
S
K
A
Y
S
P
R
Y
S
I
S
D
Site 127
S1197
K
A
Y
S
P
R
Y
S
I
S
D
R
T
S
I
Site 128
S1199
Y
S
P
R
Y
S
I
S
D
R
T
S
I
S
D
Site 129
S1203
Y
S
I
S
D
R
T
S
I
S
D
P
P
E
S
Site 130
S1205
I
S
D
R
T
S
I
S
D
P
P
E
S
P
P
Site 131
S1210
S
I
S
D
P
P
E
S
P
P
L
L
P
P
R
Site 132
T1222
P
P
R
E
P
V
R
T
P
D
V
F
S
S
S
Site 133
S1227
V
R
T
P
D
V
F
S
S
S
P
L
H
L
Q
Site 134
S1228
R
T
P
D
V
F
S
S
S
P
L
H
L
Q
P
Site 135
S1229
T
P
D
V
F
S
S
S
P
L
H
L
Q
P
P
Site 136
S1242
P
P
P
L
G
K
K
S
D
H
G
N
A
F
F
Site 137
S1252
G
N
A
F
F
P
N
S
P
S
P
F
T
P
P
Site 138
S1254
A
F
F
P
N
S
P
S
P
F
T
P
P
P
P
Site 139
T1257
P
N
S
P
S
P
F
T
P
P
P
P
Q
T
P
Site 140
T1263
F
T
P
P
P
P
Q
T
P
S
P
H
G
T
R
Site 141
S1265
P
P
P
P
Q
T
P
S
P
H
G
T
R
R
H
Site 142
T1269
Q
T
P
S
P
H
G
T
R
R
H
L
P
S
P
Site 143
S1275
G
T
R
R
H
L
P
S
P
P
L
T
Q
E
V
Site 144
T1279
H
L
P
S
P
P
L
T
Q
E
V
D
L
H
S
Site 145
S1286
T
Q
E
V
D
L
H
S
I
A
G
P
P
V
P
Site 146
S1297
P
P
V
P
P
R
Q
S
T
S
Q
H
I
P
K
Site 147
T1298
P
V
P
P
R
Q
S
T
S
Q
H
I
P
K
L
Site 148
S1299
V
P
P
R
Q
S
T
S
Q
H
I
P
K
L
P
Site 149
T1309
I
P
K
L
P
P
K
T
Y
K
R
E
H
T
H
Site 150
Y1310
P
K
L
P
P
K
T
Y
K
R
E
H
T
H
P
Site 151
T1315
K
T
Y
K
R
E
H
T
H
P
S
M
H
R
D
Site 152
S1318
K
R
E
H
T
H
P
S
M
H
R
D
G
P
P
Site 153
S1332
P
L
L
E
N
A
H
S
S
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation