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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRP1
Full Name:
Prolow-density lipoprotein receptor-related protein 1
Alias:
A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; APR; CD91; Low density lipoprotein-related protein 1; Low-density lipoprotein receptor-related protein 1 precursor; LRP
Type:
Receptor, protein translocating
Mass (Da):
504575
Number AA:
4544
UniProt ID:
Q07954
International Prot ID:
IPI00020557
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005624
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0004872
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0006810
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y530
E
H
E
L
F
L
V
Y
G
K
G
R
P
G
I
Site 2
T648
T
L
I
E
G
K
M
T
H
P
R
A
I
V
V
Site 3
T1430
R
R
T
V
H
R
E
T
G
S
G
G
W
P
N
Site 4
S1432
T
V
H
R
E
T
G
S
G
G
W
P
N
G
L
Site 5
T1440
G
G
W
P
N
G
L
T
V
D
Y
L
E
K
R
Site 6
Y1443
P
N
G
L
T
V
D
Y
L
E
K
R
I
L
W
Site 7
T1498
V
Y
W
T
D
W
R
T
N
T
L
A
K
A
N
Site 8
T1500
W
T
D
W
R
T
N
T
L
A
K
A
N
K
W
Site 9
T1513
K
W
T
G
H
N
V
T
V
V
Q
R
T
N
T
Site 10
Y1587
E
F
K
K
F
L
L
Y
A
R
Q
M
E
I
R
Site 11
S1754
L
A
I
D
F
P
E
S
K
L
Y
W
I
S
S
Site 12
T1790
R
S
Q
L
G
K
A
T
A
L
A
I
M
G
D
Site 13
Y2000
R
L
N
G
S
F
R
Y
V
V
I
S
Q
G
L
Site 14
S2004
S
F
R
Y
V
V
I
S
Q
G
L
D
K
P
R
Site 15
T2156
N
R
D
R
Q
K
G
T
N
V
C
A
V
A
N
Site 16
Y2290
G
S
V
E
G
L
A
Y
H
R
G
W
D
T
L
Site 17
S3217
E
D
Y
I
E
F
A
S
L
D
G
S
N
R
H
Site 18
S3928
T
G
T
I
S
Y
R
S
L
P
P
A
A
P
P
Site 19
S4067
Y
W
A
D
A
K
L
S
V
I
G
S
I
R
L
Site 20
S4071
A
K
L
S
V
I
G
S
I
R
L
N
G
T
D
Site 21
S4249
N
G
G
T
C
A
A
S
P
S
G
M
P
T
C
Site 22
T4460
G
F
Q
H
Q
R
M
T
N
G
A
M
N
V
E
Site 23
Y4473
V
E
I
G
N
P
T
Y
K
M
Y
E
G
G
E
Site 24
Y4476
G
N
P
T
Y
K
M
Y
E
G
G
E
P
D
D
Site 25
T4500
A
L
D
P
D
K
P
T
N
F
T
N
P
V
Y
Site 26
Y4507
T
N
F
T
N
P
V
Y
A
T
L
Y
M
G
G
Site 27
Y4511
N
P
V
Y
A
T
L
Y
M
G
G
H
G
S
R
Site 28
S4517
L
Y
M
G
G
H
G
S
R
H
S
L
A
S
T
Site 29
S4520
G
G
H
G
S
R
H
S
L
A
S
T
D
E
K
Site 30
S4523
G
S
R
H
S
L
A
S
T
D
E
K
R
E
L
Site 31
T4524
S
R
H
S
L
A
S
T
D
E
K
R
E
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation