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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP1
Full Name:
Rho GTPase-activating protein 1
Alias:
CDC42 GTPase-activating protein; CDC42GAP; GTPase-activating protein rhoOGAP; P50rhoGAP; P50-RhoGAP; RHG01; Rho GTPase activating protein 1; RHOGAP; RHOGAP1; Rho-related small GTPase protein activator; Rho-type GTPase-activating protein 1
Type:
Mass (Da):
50436
Number AA:
439
UniProt ID:
Q07960
International Prot ID:
IPI00020567
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0043231
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0017124
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
P
L
S
E
L
Q
D
D
L
T
Site 2
T12
S
E
L
Q
D
D
L
T
L
D
D
T
S
E
A
Site 3
T16
D
D
L
T
L
D
D
T
S
E
A
L
N
Q
L
Site 4
S17
D
L
T
L
D
D
T
S
E
A
L
N
Q
L
K
Site 5
S27
L
N
Q
L
K
L
A
S
I
D
E
K
N
W
P
Site 6
S35
I
D
E
K
N
W
P
S
D
E
M
P
D
F
P
Site 7
S44
E
M
P
D
F
P
K
S
D
D
S
K
S
S
S
Site 8
S47
D
F
P
K
S
D
D
S
K
S
S
S
P
E
L
Site 9
S49
P
K
S
D
D
S
K
S
S
S
P
E
L
V
T
Site 10
S50
K
S
D
D
S
K
S
S
S
P
E
L
V
T
H
Site 11
S51
S
D
D
S
K
S
S
S
P
E
L
V
T
H
L
Site 12
Y64
H
L
K
W
D
D
P
Y
Y
D
I
A
R
H
Q
Site 13
Y65
L
K
W
D
D
P
Y
Y
D
I
A
R
H
Q
I
Site 14
Y81
E
V
A
G
D
D
K
Y
G
R
K
I
I
V
F
Site 15
S96
S
A
C
R
M
P
P
S
H
Q
L
D
H
S
K
Site 16
S102
P
S
H
Q
L
D
H
S
K
L
L
G
Y
L
K
Site 17
Y107
D
H
S
K
L
L
G
Y
L
K
H
T
L
D
Q
Site 18
Y115
L
K
H
T
L
D
Q
Y
V
E
S
D
Y
T
L
Site 19
S118
T
L
D
Q
Y
V
E
S
D
Y
T
L
L
Y
L
Site 20
Y120
D
Q
Y
V
E
S
D
Y
T
L
L
Y
L
H
H
Site 21
T121
Q
Y
V
E
S
D
Y
T
L
L
Y
L
H
H
G
Site 22
Y124
E
S
D
Y
T
L
L
Y
L
H
H
G
L
T
S
Site 23
T130
L
Y
L
H
H
G
L
T
S
D
N
K
P
S
L
Site 24
S131
Y
L
H
H
G
L
T
S
D
N
K
P
S
L
S
Site 25
S136
L
T
S
D
N
K
P
S
L
S
W
L
R
D
A
Site 26
S138
S
D
N
K
P
S
L
S
W
L
R
D
A
Y
R
Site 27
Y144
L
S
W
L
R
D
A
Y
R
E
F
D
R
K
Y
Site 28
Y151
Y
R
E
F
D
R
K
Y
K
K
N
I
K
A
L
Site 29
Y159
K
K
N
I
K
A
L
Y
I
V
H
P
T
M
F
Site 30
T169
H
P
T
M
F
I
K
T
L
L
I
L
F
K
P
Site 31
Y188
K
F
G
Q
K
I
F
Y
V
N
Y
L
S
E
L
Site 32
Y191
Q
K
I
F
Y
V
N
Y
L
S
E
L
S
E
H
Site 33
S193
I
F
Y
V
N
Y
L
S
E
L
S
E
H
V
K
Site 34
Y213
I
P
R
Q
V
L
K
Y
D
D
F
L
K
S
T
Site 35
S219
K
Y
D
D
F
L
K
S
T
Q
K
S
P
A
T
Site 36
S223
F
L
K
S
T
Q
K
S
P
A
T
A
P
K
P
Site 37
T226
S
T
Q
K
S
P
A
T
A
P
K
P
M
P
P
Site 38
S284
T
E
G
I
F
R
R
S
A
N
T
Q
V
V
R
Site 39
T287
I
F
R
R
S
A
N
T
Q
V
V
R
E
V
Q
Site 40
Y297
V
R
E
V
Q
Q
K
Y
N
M
G
L
P
V
D
Site 41
Y308
L
P
V
D
F
D
Q
Y
N
E
L
H
L
P
A
Site 42
S347
G
F
L
N
I
D
E
S
Q
R
V
P
A
T
L
Site 43
T353
E
S
Q
R
V
P
A
T
L
Q
V
L
Q
T
L
Site 44
T359
A
T
L
Q
V
L
Q
T
L
P
E
E
N
Y
Q
Site 45
Y365
Q
T
L
P
E
E
N
Y
Q
V
L
R
F
L
T
Site 46
S433
H
Q
G
E
L
F
P
S
P
D
P
S
G
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation