KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CYP24A1
Full Name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Alias:
1,25-dihydroxyvitamin D; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24- hydroxylase; 24-OHase; 3; CP24; CP24A; CYP24; Cytochrome P450 24A1, mitochondrial; EC 1.14.-.-; P450-CC24; Vitamin D
Type:
Oxidoreductase
Mass (Da):
58875
Number AA:
514
UniProt ID:
Q07973
International Prot ID:
IPI00020586
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005741
Uniprot
OncoNet
Molecular Function:
GO:0030342
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0001649
GO:0055114
GO:0042369
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
S
P
I
S
K
S
R
S
L
A
A
Site 2
S10
S
P
I
S
K
S
R
S
L
A
A
F
L
Q
Q
Site 3
S20
A
F
L
Q
Q
L
R
S
P
R
Q
P
P
R
L
Site 4
T29
R
Q
P
P
R
L
V
T
S
T
A
Y
T
S
P
Site 5
S30
Q
P
P
R
L
V
T
S
T
A
Y
T
S
P
Q
Site 6
T31
P
P
R
L
V
T
S
T
A
Y
T
S
P
Q
P
Site 7
Y33
R
L
V
T
S
T
A
Y
T
S
P
Q
P
R
E
Site 8
S35
V
T
S
T
A
Y
T
S
P
Q
P
R
E
V
P
Site 9
T47
E
V
P
V
C
P
L
T
A
G
G
E
T
Q
N
Site 10
T85
G
L
K
K
Q
H
D
T
L
V
E
Y
H
K
K
Site 11
Y89
Q
H
D
T
L
V
E
Y
H
K
K
Y
G
K
I
Site 12
Y93
L
V
E
Y
H
K
K
Y
G
K
I
F
R
M
K
Site 13
Y119
P
C
L
L
E
A
L
Y
R
T
E
S
A
Y
P
Site 14
S123
E
A
L
Y
R
T
E
S
A
Y
P
Q
R
L
E
Site 15
Y125
L
Y
R
T
E
S
A
Y
P
Q
R
L
E
I
K
Site 16
Y140
P
W
K
A
Y
R
D
Y
R
K
E
G
Y
G
L
Site 17
S160
E
D
W
Q
R
V
R
S
A
F
Q
K
K
L
M
Site 18
Y204
R
G
H
V
E
D
L
Y
S
E
L
N
K
W
S
Site 19
S205
G
H
V
E
D
L
Y
S
E
L
N
K
W
S
F
Site 20
Y220
E
S
I
C
L
V
L
Y
E
K
R
F
G
L
L
Site 21
T255
T
F
G
R
M
M
V
T
P
V
E
L
H
K
S
Site 22
S262
T
P
V
E
L
H
K
S
L
N
T
K
V
W
Q
Site 23
T277
D
H
T
L
A
W
D
T
I
F
K
S
V
K
A
Site 24
S294
D
N
R
L
E
K
Y
S
Q
Q
P
S
A
D
F
Site 25
S298
E
K
Y
S
Q
Q
P
S
A
D
F
L
C
D
I
Site 26
Y306
A
D
F
L
C
D
I
Y
H
Q
N
R
L
S
K
Site 27
S312
I
Y
H
Q
N
R
L
S
K
K
E
L
Y
A
A
Site 28
Y317
R
L
S
K
K
E
L
Y
A
A
V
T
E
L
Q
Site 29
Y340
N
S
L
M
W
I
L
Y
N
L
S
R
N
P
Q
Site 30
S358
K
L
L
K
E
I
Q
S
V
L
P
E
N
Q
V
Site 31
Y376
E
D
L
R
N
M
P
Y
L
K
A
C
L
K
E
Site 32
S384
L
K
A
C
L
K
E
S
M
R
L
T
P
S
V
Site 33
T388
L
K
E
S
M
R
L
T
P
S
V
P
F
T
T
Site 34
S390
E
S
M
R
L
T
P
S
V
P
F
T
T
R
T
Site 35
T394
L
T
P
S
V
P
F
T
T
R
T
L
D
K
A
Site 36
T395
T
P
S
V
P
F
T
T
R
T
L
D
K
A
T
Site 37
T402
T
R
T
L
D
K
A
T
V
L
G
E
Y
A
L
Site 38
Y407
K
A
T
V
L
G
E
Y
A
L
P
K
G
T
V
Site 39
S425
N
T
Q
V
L
G
S
S
E
D
N
F
E
D
S
Site 40
S432
S
E
D
N
F
E
D
S
S
Q
F
R
P
E
R
Site 41
S433
E
D
N
F
E
D
S
S
Q
F
R
P
E
R
W
Site 42
Y483
L
C
W
I
V
R
K
Y
D
I
Q
A
T
D
N
Site 43
S498
E
P
V
E
M
L
H
S
G
T
L
V
P
S
R
Site 44
S504
H
S
G
T
L
V
P
S
R
E
L
P
I
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation