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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AES
Full Name:
Amino-terminal enhancer of split
Alias:
AES-1; AES-2; Amino enhancer of split; ESP1; Gp130-associated protein GAM; GRG; GRG protein; GRG5; TLE5
Type:
Transcription, coactivator/corepressor, Nuclear receptor co-regulator
Mass (Da):
21970
Number AA:
197
UniProt ID:
Q08117
International Prot ID:
IPI00432493
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
M
F
P
Q
S
R
H
S
G
S
S
H
L
P
Q
Site 2
S11
P
Q
S
R
H
S
G
S
S
H
L
P
Q
Q
L
Site 3
S12
Q
S
R
H
S
G
S
S
H
L
P
Q
Q
L
K
Site 4
T21
L
P
Q
Q
L
K
F
T
T
S
D
S
C
D
R
Site 5
S23
Q
Q
L
K
F
T
T
S
D
S
C
D
R
I
K
Site 6
S25
L
K
F
T
T
S
D
S
C
D
R
I
K
D
E
Site 7
Y40
F
Q
L
L
Q
A
Q
Y
H
S
L
K
L
E
C
Site 8
S55
D
K
L
A
S
E
K
S
E
M
Q
R
H
Y
V
Site 9
Y61
K
S
E
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Site 10
Y64
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
Site 11
Y65
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
N
Site 12
Y69
V
M
Y
Y
E
M
S
Y
G
L
N
I
E
M
H
Site 13
Y95
I
C
A
Q
V
L
P
Y
L
S
Q
E
H
Q
Q
Site 14
S97
A
Q
V
L
P
Y
L
S
Q
E
H
Q
Q
Q
V
Site 15
T115
I
E
R
A
K
Q
V
T
A
P
E
L
N
S
I
Site 16
T143
Q
A
L
A
L
P
L
T
P
L
P
V
G
L
Q
Site 17
S171
L
S
L
S
A
L
G
S
Q
A
H
L
S
K
E
Site 18
S176
L
G
S
Q
A
H
L
S
K
E
D
K
N
G
H
Site 19
T187
K
N
G
H
D
G
D
T
H
Q
E
D
D
G
E
Site 20
S196
Q
E
D
D
G
E
K
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation